Activities and ph tests for the determination of the risk of obstetric and gynecologic complications

A risky, gynecological technology, applied in biochemical equipment and methods, biological testing, measuring devices, etc., to solve problems such as inability to distinguish or identify women

Inactive Publication Date: 2005-07-13
UNIBIO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In addition, the test does not differentiate or identify women who may develop conditions such as early preterm birth in the first trimester of pregnancy

Method used

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Comparison scheme
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Embodiment Construction

[0029] Through multiple detailed studies, it has surprisingly been found that the identification of a pH threshold ≥ 5.0 in combination with hypersialidase and / or aminoacylproline dipeptidase activity in body fluid samples for selection of women at risk of developing the above conditions is A key issue, these women are at significantly 20 or even 30 times higher risk than the average woman.

[0030] It will be appreciated that, according to the present invention, not only those women at risk of developing the above-mentioned conditions can be identified, but also, advantageously, those women at high risk who have not been identified before can be identified, in addition to those women who are at risk in the first trimester of pregnancy. The risk of getting the worst possible bad outcome.

[0031] It should be noted that this method can be applied to pregnant as well as non-pregnant, pregnant, perimenopausal and postmenopausal women.

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Abstract

The present invention provides a method for selecting a specific population of women at risk of developing an obstetric or gynecological condition, the risk being expressed by an odds ratio (OR) value higher than 5.5, the method comprising the following steps in sequence: a) passing Determination of sialidase levels in body fluid samples by the method described by Cauci et al. in Am. J. Obstet. Gynecol. 1998; vol. 178; p511-5, and / or, by Cauci et al. in J. Infect. Dis.1998; vol.178; method described in p1698-706, to determine the activity of aminoacyl proline dipeptidase in a body fluid sample; b) determine the pH value of the body fluid sample; c) select a value with sialidase Samples with equal or higher than 5.0 nmol methoxyphenol and / or aminoacyl proline dipeptidase levels equal to or higher than 1500 mOD and pH ≥ 5.0. Thus, this approach provides physicians with an effective tool in deciding whether to administer drug therapy to women at risk of serious adverse outcomes.

Description

technical field [0001] In general, the present invention relates to an enzyme test method and / or two combined enzyme test methods combined with pH assessment for determining the risk of obstetrical complications, and in particular, the present invention relates to a method using A method for selecting a population of women at high risk of developing conditions associated with obstetrical and gynecological complications, urological disorders, sexually transmitted diseases, viral infections, and malignancies in the genitourinary tract. Background technique [0002] A variety of conditions associated with obstetrical complications are well known to physicians, eg, low birth weight (<2500 g at birth, LBW), very low birth weight (<1500 g at birth, VLBW), spontaneous preterm birth (spontaneous delivery before 37 weeks of gestation, PTD), early preterm delivery including all natural or induced preterm births (delivery before 35 weeks, or 34 weeks, or 32 weeks of gestation, EP...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/34C12Q1/37G01N33/68
CPCC12Q1/34C12Q1/37G01N33/6893G01N2800/36
Inventor 萨比纳·考兹
Owner UNIBIO CORP
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