Use of investigating multiple antigen label combined by antibody absorption surface material and mass spectrum

A biomarker, antibody technology, used in clinical testing. It can solve the problem that disease markers cannot be detected at the same time

Inactive Publication Date: 2005-08-24
许洋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using antibodies and three-color fluorescence, up to three disease markers can be detected, but more than three disease markers cannot be detected at the same time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Distinguishing between normal people and various diseases by antigenic markers in blood

[0018] (1) Experimental method

[0019] 1. Materials

[0020] 1. Specimen source: collect serum / plasma samples from clinically diagnosed patients. 50 cases of control group (normal people, known chorionic gonadotropin, alpha-fetoprotein, thyrotropin, lactate dehydrogenase, creatine kinase isoenzyme, aspartate transferase, transferrin, fibrin All were normal); 15 pregnant women complicated with hyperthyroidism, heart failure or myocardial infarction patients (known chorionic gonadotropin, alpha-fetoprotein, thyroid stimulating hormone, lactate dehydrogenase, creatine kinase aminotransferase, transferrin, fibrinogen all increased); 16 patients with myocardial infarction (only lactate dehydrogenase, creatine kinase isoenzyme increased); 14 patients with hyperthyroidism (only thyroid stimulating hormone, transferrin increased); 12 normal pregnant women (only chorionic gona...

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PUM

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Abstract

This invention relates to a method which is through the antigen mark which is caught by the immune body adsorption surface matter on, and analyzes with the mass spectrum examines. Adsorbs the many kinds of antigen mark in on a many kinds of immune bodies adsorptions surface, and carries on the mass spectrum analysis to the capture antigen mark. May examine many antigen mark group. This method may use examining the antigen mark combination in the biological sample. Examines the measurement with these antigen mark combinations to be possible at the same time to distinguish the many kinds of diseases.This method is accurate, convenience also quickly.

Description

technical field [0001] The invention relates to a new protein analysis method in biological samples, a biomarker captured by antibody adsorption surface substances, and mass spectrometry to detect the biomarker. The invention mentioned here greatly improves the method of immunoassay, which is more accurate than the current conventional biochemical examination (enzyme-linked method or fluorescence method). More specifically, the invention relates to multiple forms of biomarkers or antigen markers that can be used to distinguish multiple disease markers at once with higher specificity and sensitivity. The present invention can be applied to clinical tests. Background technique [0002] Both normal function and pathological characteristics of cells depend to some extent on the function of proteins expressed by cells. Therefore, identifying the differences in proteins expressed by diseases in the human body can be used for disease diagnosis and screening, and ultimately for dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/577
Inventor 许洋
Owner 许洋
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