Amide derivative

Abstract

There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. An N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.

Description

technical field [0001] The present invention relates to a novel amide derivative for use as a medicament, especially for the prophylaxis and treatment of diseases involving herpes viruses. Background technique [0002] Viruses of the herpesviridae family cause a wide variety of infectious diseases in humans and animals. For example, it is well known that varicella-zoster virus (VZV) may cause chickenpox and herpes zoster, and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) may cause infections such as herpes labialis and genital herpes, respectively. In addition, in recent years, infections caused by herpes viruses such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus 6, 7, and 8 have also been clarified. [0003] Now, nucleic acid drugs such as acyclovir (ACV) and its prodrugs valacyclovir (VCV) and famciclovir (FCV) are used as drugs against herpes viruses such as VZV and HSV. These nucleic acid drugs are monophosphorylated into nucleoside m...

AI Technical Summary

Problems solved by technology

However, the anti-VZV activity of these co

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