Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Amide derivative

A technology of amide derivatives and carbamoyl, applied in the field of novel amide derivatives, can solve the problems such as the fact that the anti-VZV activity is not specifically disclosed and the like

Active Publication Date: 2006-09-13
ASTELLAS PHARMA INC
View PDF3 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the anti-VZV activity of these compounds has not been specifically revealed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Amide derivative
  • Amide derivative
  • Amide derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 49

[0137] Compound of Example 49, Reference 3

[0138]

[0139] Comparative compound B:

Embodiment 85

[0140] Compound of Example 85, Reference 3

[0141]

[0142] Comparative compound C:

Embodiment 87

[0143] Compound of Example 87, reference 3

[0144]

[0145] Comparative compound D:

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. An N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.

Description

technical field [0001] The present invention relates to a novel amide derivative for use as a medicament, especially for the prophylaxis and treatment of diseases involving herpes viruses. Background technique [0002] Viruses of the herpesviridae family cause a wide variety of infectious diseases in humans and animals. For example, it is well known that varicella-zoster virus (VZV) may cause chickenpox and herpes zoster, and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) may cause infections such as herpes labialis and genital herpes, respectively. In addition, in recent years, infections caused by herpes viruses such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus 6, 7, and 8 have also been clarified. [0003] Now, nucleic acid drugs such as acyclovir (ACV) and its prodrugs valacyclovir (VCV) and famciclovir (FCV) are used as drugs against herpes viruses such as VZV and HSV. These nucleic acid drugs are monophosphorylated into nucleoside m...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D249/06C07D271/06C07D263/32C07D413/12C07D409/12C07D413/14C07D417/14A61K31/4192A61K31/4245A61K31/421A61K31/541A61K31/422A61K31/382A61K31/4439A61K31/404A61K31/427A61K31/416A61P31/22C07D335/02
CPCC07D413/12C07D335/02A61P31/00A61P31/18A61P31/22A61K31/382
Inventor 绀谷徹宫田淳司濵口涉河野友昭神川晃雄鈴木弘周藤健治
Owner ASTELLAS PHARMA INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com