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Accelerometer-based monitoring of the frequency dynamics of the isovolumic contraction phase and pathologic cardiac vibrations

a technology of isovolumic contraction and accelerometer, which is applied in the field of accelerometer-based monitoring of the frequency dynamics of the isovolumic contraction phase and the pathologic cardiac vibration, can solve the problems of reducing the sensitivity of acceleration signal measurement and the interpretation of this measuremen

Inactive Publication Date: 2006-08-10
CARDIOSYNC
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  • Application Information

AI Technical Summary

Benefits of technology

[0007] Monitoring changes in the frequency of the vibrational component of the ICP may be more practical and accurate than measuring amplitude changes for assessing cardiac function. Similarly, monitoring the time interval of this phase may prove more practical and accurate. Such an approach would reduce the sensitivity of the acceleration signal measurement and the interpretation of this measurement to the effects of gravity, sensor axis orientation, relative motion of the sensing device to which the sensor is affixed, and translational motion of the heart.

Problems solved by technology

Such an approach would reduce the sensitivity of the acceleration signal measurement and the interpretation of this measurement to the effects of gravity, sensor axis orientation, relative motion of the sensing device to which the sensor is affixed, and translational motion of the heart.

Method used

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  • Accelerometer-based monitoring of the frequency dynamics of the isovolumic contraction phase and pathologic cardiac vibrations
  • Accelerometer-based monitoring of the frequency dynamics of the isovolumic contraction phase and pathologic cardiac vibrations
  • Accelerometer-based monitoring of the frequency dynamics of the isovolumic contraction phase and pathologic cardiac vibrations

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Embodiment Construction

[0018] A graph of the cardiac filling and pumping cycle and valvular events is shown in FIG. 1. The cardiac LV pumping cycle (LV cycle) is divided into two periods: diastole and systole. Diastole is the filling period and systole is the ejection period. Five different phases of the LV cycle can be identified within the systolic and diastolic periods: isovolumic contraction 56, ejection 58, isovolumic relaxation 62, early diastolic filling (rapid filling) 64, and late diastolic filling (atrial contraction) 66. Mitral valve closure 68 (“MVC”) occurs during isovolumic contraction and aortic valve closure 72 (“AVC”) occurs during isovolumic relaxation. Also shown in the figures are the left ventricular pressure LV Press 74, a regular electrocardiogram ECG 76, the left ventricular end-diastolic volume LVEDV 78, the left ventricular end-systolic volume LVESV 82, a graph depicting heart sounds 84, the left atrial pressure LA Press 86, the aortic pressure 88, a-wave 92, c-wave 94, and v-wav...

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Abstract

Methods and systems are disclosed that characterize cardiac function using an acceleration sensor to acquire and analyze the frequency dynamics associated with the isovolumic contraction phase (“ICP”). This information can be used to characterize heart function; optimize therapy for cardiomyopathy, including CRT therapy (including pacing intervals and required pharmacologic therapy); and to optimize CCM therapy. In addition, this information can be used to identify target pacing regions for CRT lead placement. Further, analyzing the frequency dynamics can be used to characterize pathologic heart vibrational motion, such as mitral regurgitation and the third or fourth heart sound, and the response of this motion to therapy for cardiomyopathy.

Description

STATEMENT OF RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Application No. 60 / 650,532, filed Feb. 7, 2005, U.S. Provisional Application No. 60 / 655,038, filed Feb. 22, 2005, U.S. Provisional Application No. 60 / 656,307, filed Feb. 25, 2005, U.S. Provisional Application No. 60 / 657,766, filed Mar. 1, 2005, U.S. Provisional Application No. 60 / 659,658, filed Mar. 8, 2005, U.S. Provisional Application No. 60 / 663,788, filed Mar. 21, 2005, U.S. Provisional Application No. 60 / 669,324, filed Apr. 7, 2005, U.S. Provisional Application No. 60 / 677,569, filed May 4, 2005 and U.S. Provisional Application No. 60 / 680,673, filed May 13, 2005. Each of the prior U.S. Provisional Patent Applications is incorporated by reference in its entirety herein. [0002] This application is also related to U.S. patent application Ser. No. 11 / 318,325, filed Dec. 23, 2005, entitled “Devices and Methods For Accelerometer-Based Characterization of Cardiac Function and Identification ...

Claims

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Application Information

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IPC IPC(8): A61B5/04
CPCA61B5/02A61B5/0456A61B2562/0219A61B2562/028A61N1/056A61N1/3627A61N1/36542A61N1/36585A61N2001/0585A61B7/00A61B5/352
Inventor DOBAK, JOHN D. III
Owner CARDIOSYNC
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