Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic
transducer configured to emit an ultrasonic
backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic
transducer; (b) an
integrated circuit comprising (i) a variable frequency power supply electrically connected to a first
electrode and a second
electrode; (ii) a
signal detector configured to detect an impedance,
voltage, or current in a circuit comprising the variable frequency power supply, the first
electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic
transducer based on the detected impedance,
voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in
electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.