24results about "Microscale sensors" patented technology

Measurements are performed on biological subjects by using microstructures to penetrate the functional barriers of the target. [Solution] A system for performing measurements on a biological object, comprising: at least one substrate 511 including a plurality of plate microstructures 512.1, 512.2 configured to penetrate the stratum corneum of the object; at least one sensor operably connected to at least one microstructure and configured to measure a response signal from at least one microstructure; and one or more electronic processing devices configured to perform at least one of the following: determine the measured response signal, provide an output based on the measured response signal, perform an analysis using at least part of the measured response signal, and store data indicating at least part of the measured response signal.

Systems and methods are provided for determining an acceleration at a location of interest within one of a user's head and neck. At least one of linear acceleration data, angular acceleration data, angular velocity data, and orientation data is produced using at least one sensing device substantially rigidly attached to an ambient-accessible surface of the user's head. The location of interest is represented relative to a position of the at least one sensing device as a time-varying function. An acceleration at the location of interest is calculated as a function of the data produced at the sensing device and the time-varying function representing the location of interest. The calculated acceleration at the location of interest is provided to at least one of the user and an observer in a human-perceptible form.

A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes / ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

Disclosed is an implant and method of making an implant. The implant having a housing that defines a cavity. The housing includes a sensor comprising a base attached to a diaphragm wherein said base may be positioned within said cavity. The sensor may be a capacitive pressure sensor. The diaphragm may be connected to the housing to hermetically seal said housing. The sensor may include electrical contacts positioned on the diaphragm. The attachment between the base and the diaphragm may define a capacitive gap and at least one discontinuity configured to enhance at least one performance parameter of said implant.

Compositions and cross-linked polymer networks including at least one soft fluoropolymer segment and at least one hard fluorinated polymer segment which are covalently bonded through a linking moiety are provided. Methods of making the compositions and networks, and devices that incorporate them are also provided. The polymer networks may be designed to exhibit specific mechanical or physical properties which are tunable through by synthetic techniques including variation in the number and / or identity of the hard fluorinated polymer segments and soft fluoropolymer segments.

The present invention discloses a dry electrode comprising: an electrical connector with a second major portion comprising an electrode plate portion and a first major portion comprising a head portion; and a discontinuous layer of electrically conductive particles in electrical contact with the second major portion of the electrical connector, and wherein the electrically conductive particles comprise non-compressive ceramic shaped particles with at least one point and with a conductive metal coating wherein at least one dimension of the shaped particles is 100-1,500 micrometers.

An electrochemical sensor device for introducing a needle electrode into the skin of a subject to contact a target body fluid or tissue and detect a target analyte. The device has a movable part for biasing the needle electrode against the skin of the subject and a power management function for supplying operating power to the sensor electronics before and after the device is disposed.

A neural microprobe is disclosed. The neural microprobe comprises a stacked structure having a base layer, a core layer, a metal layer, and a ceiling layer. The base layer is formed from a first species of biocompatible polymer. The core layer is formed from a second species of biocompatible polymer deposited on the base layer. The metal layer is deposited on the core layer. The ceiling layer is formed from the first species of biocompatible polymer deposited on the metal layer and comprises a plurality of trenches etched through the ceiling layer to expose portions of the metal layer, said exposed portions defining electrodes of an electrode array of the neural microprobe. The first species of biocompatible polymer has a lower coefficient of thermal expansion than the second species. A method of manufacturing a neural microprobe comprises providing a first mask on the ceiling layer, wherein the first mask is lithographically patterned to define a plurality of gaps in the first mask; providing a second mask on the first mask; etching, with a first etchant, through the second mask and the gaps in the first mask, trenches in the ceiling layer to expose the portions of the metal layer defining the electrodes of the electrode array; and etching, with a second etchant, the stacked structure to remove any remaining portions of the first and second masks, and to release a base layer of the stacked structure from the release layer.

An implantable sensor system using one or more sensor implants comprised of micro-electrical mechanical system (MEMS) sensors for the accurate and continuous measurement of physiological hemodynamic signals such as diastolic and systolic blood pressure. Sensor implants are configured to be subcutaneously injected to a placement site adjacent a blood vessel. In some embodiments, sensors comprise micromachined ultrasonic transducers.

This application discloses a measurement method, a system, and a related apparatus. The method is applied to a first electronic device, the first electronic device includes a first electrode group and a second electrode group, and a distance between the first electrode group and the second electrode group is greater than a first distance. When the first electrode group and the second electrode group are implanted into a subcutaneous tissue, the method includes: determining a first physiological parameter by using the first electrode group; and determining an electrocardiography signal by using the first electrode group and the second electrode group. In this way, the first electronic device may obtain an electrocardiography signal of a user anytime and anywhere, and may further measure one or more other physiological parameters (for example, blood glucose, blood ketone, blood lactic acid, and uric acid) of the user at the same time, to improve health monitoring efficiency.

An apparatus includes a catheter assembly for use in a medical procedure to conduct electrophysiological mapping. The catheter assembly includes a catheter having an end effector with a tip member. One or more insert-molded microelectrodes are located in the tip member of the end effector for conducting electrophysiological mapping. The insert-molded microelectrodes include a microelectrode and a composite that isolates the microelectrode from contact with the tip member.

A wearable cardiac ultrasound patch, a cardiovascular disease identification system, and method thereof integrate a silicon photonic integrated circuit layer with a microelectromechanical integrated circuit layer into an optical fiber micro-sensor, which is encapsulated with a computing chip as a single unit. This allows the examinee to perform cardiac ultrasound detection and processing in a wearable and convenient manner, free from time or geographic constraints. The silicon photonic elements in the silicon photonic integrated circuit layer and the piezoelectric elements in the microelectromechanical integrated circuit layer are stacked and arranged in a two-dimensional array, enabling the wearable cardiac ultrasound patch to scan at more angles. Furthermore, the cardiovascular disease identification system of the present invention can process the examinee's cardiac ultrasound signals, electrocardiography (ECG) signals, and phonocardiography (PCG) signals. These three data types cross-validate one another, improving the detection rate of comprehensive cardiovascular diseases and reducing the time and misdiagnosis rate for physicians diagnosing cardiovascular diseases.

The present invention relates to an implant (1, 30, 50, 70) comprising a non-metallic structural part (4, 38, 73) made of a fibre reinforced composite and having isoelastic properties with bone. The implant also comprises a first reference stress level sensor (6, 31, 51, 76) arranged in connection with the structural part, and a second osseointegration level sensor (7, 32, 52, 77) arranged on a surface of the structural part and capable of becoming attached to the bone during osseointegration of the implant.

Disclosed are devices, systems and methods for epidermal monitoring of a fluid on skin. In some aspects, a device includes an electrochemical sensor comprising two or more electrodes disposed on a first flexible substrate; a microfluidic device comprising a second flexible substrate coupled to the first substrate and structured to include (i) a channel in a first cavity of the second substrate, (ii) one or more holes that connect to the channel and provide one or more inlets, and (iii) a reservoir connected to the channel, in which the electrochemical sensor is aligned with the reservoir; and an adhesion layer coupled to the microfluidic device and attachable to skin, and the device being operable to detect a biomarker in a fluid in secreted by the skin into the microfluidic device.

An implantable sensor device includes a deflectable diaphragm layer comprising vapor- deposited thin- film metal, a first capacitive electrode conformally formed on a first side of the deflectable diaphragm layer, and a second capacitive electrode coupled to a rigid substrate, the second capacitive electrode and the first capacitive electrode forming a variable capacitor. An implantable sensor device is manufactured by depositing a layer of thin-film metal on a substrate using a physical vapor deposition process and depositing a conformal layer of electrical conductor on a stack including the layer of thin-film metal.

An implantable neuromodulation system is provided comprising at least one stimulation microelectrode, at least one microelectrode, and a frequency-shaping amplifier (FSA). The at least one stimulation microelectrode is configured to deliver a desired electrical stimulation to a neuronal population. The at least one recording microelectrode is configured to receive neural signals from the neuronal population. The FSA is coupled to the at least one recording microelectrode. The FSA is configured to allow for simultaneous electrical recording and electrical stimulation of the neuronal population.

The present application provides a wearable heart ultrasound patch, a cardiovascular disease identification system and a method thereof. A silicon photon integrated circuit layer and a micro-electro-mechanical integrated circuit layer are integrated into a fiber type micro sensor, and the micro sensor is packaged with a computing chip to realize the detection and processing of heart ultrasound in a wearable and convenient way without time or geographical restrictions. Each silicon photon component in the silicon photon integrated circuit layer and each piezoelectric component in the micro-electro-mechanical integrated circuit layer are respectively arranged in a two-dimensional array to enable the wearable heart ultrasound patch to scan more angles. Furthermore, the cardiovascular disease identification system can process the heart ultrasound, electrocardio signals and heart sound signals of the subject, and the data of the three signals are verified with each other to improve the detection rate of comprehensive cardiovascular diseases and reduce the time and misjudgment of doctors in diagnosing cardiovascular diseases.

Microchannels in hydrogels play an essential role in enabling a smart contact lens. A wearable contact lens is disclosed herein that uses microchannels and connected chambers located in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogel that is used in a commercial contact lens with three-dimensional (3D) printed mold. The corresponding capillary flow behaviors in these microchannels were investigated. Different capillary flow regimes were observed in these microchannels, depending on the hydration level of the hydrogel material. In particular, it was found that a peristaltic pressure could reinstate flow in a dehydrated microchannel, indicating the motion of eye-blinking may help tear flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. Micro-engineered contact lenses formed using poly(HEMA) hydrogel can be used for various biomedical applications such as eye-care and wearable biosensing.

According to an aspect there is provided a device for analyzing a speckle pattern from biological tissue, the device comprising: a light source configured to generate light for illuminating the biological tissue, such that the light is scattered by the biological tissue and forms the speckle pattern; a Fourier transform element configured to collect the light scattered by the biological tissue and to transform the collected light into a spatial Fourier domain at a Fourier plane of the Fourier transform element; a spatial bandpass filter arranged at the Fourier plane, the spatial bandpass filter being configured to selectively transmit light at a spatial position of the Fourier plane, the spatial position corresponding to a band of speckle sizes of the speckle pattern; a photosensitive detector configured to detect the light transmitted though the bandpass filter, wherein a signal output from the photosensitive detector comprises information on contrast of the speckle pattern.

An implantable sensor device includes a deflectable diaphragm layer comprising vapor-deposited thin-film metal, a first capacitive electrode conformally formed on a first side of the deflectable diaphragm layer, and a second capacitive electrode coupled to a rigid substrate, the second capacitive electrode and the first capacitive electrode forming a variable capacitor. An implantable sensor device is manufactured by depositing a layer of thin-film metal on a substrate using a physical vapor deposition process and depositing a conformal layer of electrical conductor on a stack including the layer of thin-film metal.

A wearable device includes an elastically compliant body having a side for attaching to skin of a patient, a plurality of accelerometers for receiving acoustic wave data from acoustic waves transmitted by a transducer, a short-range radio transmitter for transmitting the acoustic wave data to a computing device, a processor for receiving the acoustic wave data from the plurality of accelerometers and providing the acoustic wave data to the short-range radio transmitter, and a battery for providing power to the processor, the plurality of accelerometers, and the short-range radio transmitter. A distance between each accelerometer of the plurality of accelerometers is predetermined. The processor, the plurality of accelerometers, the short-range radio transmitter, and the battery are embedded within the elastically compliant body.

A dental vision system includes an intraoral camera component that can be placed inside a patient's mouth and manually moved by a user to acquire patient image data from various viewpoints within the mouth. The intraoral camera component has an inertial accelerometer and at least two camera modules. The inertial accelerometer is configured to collect position and movement data associated with the intraoral camera component. A camera controller linked to the intraoral camera component receives the patient image data and the position and movement data associated with the intraoral camera component, and is configured to determine a selected viewing orientation of the patient image data based at least in part on the position and movement data.

A system and method for monitoring body chemistry of a user, the system comprising: a housing supporting: a microsensor comprising a first and second working electrode, a reference electrode, and a counter electrode, and configured to access interstitial fluid of the user, and an electronics subsystem comprising a signal conditioning module that receives a signal stream, from the microsensor, wherein the electronics subsystem is configured to detect an impedance signal derived from two of the first working electrode, the second working electrode, the reference electrode, and the counter electrode; and a processing subsystem comprising: a first module configured to generate an analysis indicative of an analyte parameter of the user and derived from the signal stream and the impedance signal, and a second module configured to transmit information derived from the analysis to the user, thereby facilitating monitoring of body chemistry of the user.

Microchannels in hydrogels play an essential role in enabling a smart contact lens. A wearable contact lens is disclosed herein that uses microchannels and connected chambers located in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogel that is used in a commercial contact lens with three-dimensional (3D) printed mold. The corresponding capillary flow behaviors in these microchannels were investigated. Different capillary flow regimes were observed in these microchannels, depending on the hydration level of the hydrogel material. In particular, it was found that a peristaltic pressure could reinstate flow in a dehydrated microchannel, indicating the motion of eye-blinking may help tear flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. Micro-engineered contact lenses formed using poly(HEMA) hydrogel can be used for various biomedical applications such as eye-care and wearable biosensing.