DNA-protein fusions and uses thereof

a technology of dna-proteins and fusions, applied in the field of dnaprotein fusions, can solve problems such as irreversible loss of encoded information
US20080051299A1Inactive Publication Date: 2008-02-28BRISTOL MYERS SQUIBB CO
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BRISTOL MYERS SQUIBB CO
Publication Date
2008-02-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of the filing date of co-pending U.S. utility application, U.S. Ser. No. 09 / 453,190, filed Dec. 2, 1999, and U.S. provisional application, U.S. Ser. No. 60 / 110,549, filed Dec. 2, 1998, now abandoned, all hereby incorporated by reference.BACKGROUND OF THE INVENTION

[0002] In general, the invention features DNA-protein fusions and their uses, particularly for the selection of desired proteins and their corresponding nucleic acid sequences.

[0003] Recently, a combinatorial method was developed for the isolation of proteins with desired properties from large pools of proteins (Szostak et al., U.S. Ser. No. 09 / 007,005; Szostak et al., WO98 / 31700; Roberts & Szostak, Proc. Natl. Acad. Sci. USA (1997) vol. 94, p. 12297-12302). By this method, the protein portion is linked to its encoding RNA by a covalent chemical bond. Due to the covalent nature of this linkage, selection experiments are not limited to the e...

Claims

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