Pharmaceutical Compositions and Methods for Treating or Preventing Oxalate-Related Disease

a technology of oxalate-related diseases and compositions, applied in the direction of drug compositions, bacteria material medical ingredients, metabolic disorders, etc., can solve the problems of reducing the amount of oxalate available for absorption, reducing the concentration of soluble oxalate in the intestine, etc., to reduce the risk of developing oxalate-related disorders, reduce the amount of oxalate, and reduce the risk of systemic oxala

Inactive Publication Date: 2010-02-04
OXTHERA INC
View PDF29 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]The present invention comprises compositions and methods for treating and preventing oxalate-related conditions. Compositions of the present invention comprise pharmaceutical compositions comprising microorganisms and / or enzymes that reduce oxalate. Methods of the present invention comprise administering the pharmaceutical compositions to treat or prevent oxalate-related conditions, and methods for making such pharmaceutical compositions. One embodiment comprises methods which reduce the risk for developing oxalate-related disorders by reducing the amount of oxalate in the gastrointestinal tract. This reduction in the gastrointestinal tract leads to a reduction in systemic oxalate levels thereby promoting good health.
[0011]In one embodiment of the subject invention, a reduction in oxalate absorption is achieved by supplying oxalate-degrading bacteria to the gastrointestinal tract. In an embodiment, these bacteria are Oxalobacter formigenes. These bacteria use oxalate as a substrate. This utilization reduces the concentration of soluble oxalate in the intestine and, thus, the amount of oxalate available for absorption. A reduction of oxalate in the gastrointestinal tract can also lead to removal of oxalate from the circulatory system. Methods of the present invention contemplate an overall reduction of the oxalate load in an individual.
[0012]In a specific embodiment, the subject invention provides methods and compositions for the delivery of viable O. formigenes to the gastrointestinal tracts of persons who are at increased risk for oxalate-related disease. Bacteria remove oxalate from the intestinal tract, thereby reducing the amount of oxalate available for absorption and leading to increased oxalate excretion from the blood into the intestines.

Problems solved by technology

This utilization reduces the concentration of soluble oxalate in the intestine and, thus, the amount of oxalate available for absorption.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical Compositions and Methods for Treating or Preventing Oxalate-Related Disease
  • Pharmaceutical Compositions and Methods for Treating or Preventing Oxalate-Related Disease
  • Pharmaceutical Compositions and Methods for Treating or Preventing Oxalate-Related Disease

Examples

Experimental program
Comparison scheme
Effect test

example 1

Treatment of High Risk Patients

[0098]Primary Hyperoxaluric patients were fed enteric coated capsules containing freeze dried powder of O. formigenes twice a day preferable with their two big meals of the day. Each size-2 capsule contained about 137 mg of lyophilized bulk powder containing at least 108 Colony Forming Units (CFUs) / gram.

[0099]For high risk subjects this may be a life long treatment. Subjects in clinical studies showed that colonization dropped when the treatment was stopped. In the clinical study, treatment was done for 4 weeks and there was a two week follow up. The 4-week treatment resulted in significant decrease in blood and urinary oxalate levels as compared to the baseline levels. But during the follow up period, the stool counts for Oxalobacter dropped and the plasma and urine oxalate values started to increase. Thus, it is proposed that continuous feeding of oxalate-reducing compositions will be needed to provide the reduced oxalate conditions. Compositions com...

example 2

Treatment of Low Risk Patients:

[0108]Enteric protected O. formigenes cells, such as provided in enteric coated capsules can also be ingested by individuals in populations at lower risk for oxalate related disease. It would be desired to colonize these patients with one or two treatments comprising compositions of oxalate-reducing materials, such as oxalate-reducing bacteria. These patients could also routinely receive treatments of oxalate-reducing materials, either as supplements or as additions to foods such as milk or yogurt. These include:

[0109]1. Persons that have lost populations of normal oxalate degrading bacteria due to: treatments with oral antibiotics or bouts of diarrheal disease.

[0110]2. Infants can be inoculated so that a normal protective population of Oxalabacter will be more easily established than is the case later in life when competitive exclusion principles operate.

[0111]The persons or animals who are low risk are treated two times a day, with a capsule designed...

example 3

[0112]Use of Oxalate Degrading Enzymes from Oxalobacter formigenes to Control Hyperoxaluria

[0113]A study was conducted to evaluate the efficacy of oxalate degrading enzymes from Oxalobacter formigenes for the control of hyperoxaluria.

[0114]Animals Used: Male Sprague Dawley Rats: BW 250-300 g

[0115]Diets Used: Normal Diet (N.D.): Harlan Teklad TD 89222; 0.5% Ca, 0.4% P

[0116]Drug Used: Lyophilized mixture of Oxalobacter formigenes lysate (source of enzymes) with Oxalyl CoA, MgCl2 and TPP.

[0117]Drug Delivery System (Capsules): Size 9 capsules for preclinical rat studies (Capsu-Gel). Enteric Coating Eudragit L-100-55 (Hulls America, Inc.). Basal 24 hr urine collection. Fecal analysis for Oxalobacter formigenes—rats were not colonized with Oxalobacter formigenes.

[0118]Experimental Protocol:

[0119]A. Long-term Studies:

[0120]Animal Protocol:

[0121]Group I (n=4): Fed oxalate diet with lysate. Rats were given two capsules everyday at 4:00 p.m. and oxalate diet overnight. Diet was removed durin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
timeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to view more

Abstract

The present invention comprises methods and compositions for the reduction of oxalate in humans, animals and plants. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing pharmaceutical compositions to the intestinal tracts of persons and animals. The methods and compositions can be used in treating and preventing oxalate-related conditions.

Description

CROSS-REFERENCE TO A RELATED APPLICATION[0001]This application is a continuation-in-part of PCT / US05 / 021134, filed Jun. 15, 2005, which is a continuation-in part of U.S. patent application Ser. No. 10 / 868,242, filed Jun. 15, 2004, which is a continuation-in-part of a co-pending U.S. application Ser. No. 10 / 671,299, filed Sep. 24, 2003; which is a continuation of U.S. application Ser. No. 10 / 093,686, filed on Mar. 8, 2002; which is a continuation of U.S. application Ser. No. 09 / 500,500, filed Feb. 9, 2000; which claims the benefit of U.S. Provisional Application No. 60 / 150,259, filed Aug. 23, 1999, and which is a continuation-in-part of co-pending U.S. application Ser. No. 09 / 083,362, filed May 22, 1998 which claims the benefit of U.S. Provisional Application No. 60 / 047,473, filed May 23, 1997.FIELD OF THE INVENTION[0002]The present invention relates to compositions and methods for treating and preventing oxalate related conditions. More particularly, the invention relates to composi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/74A61K9/48A61P1/00A61P9/00
CPCA23L1/3014A61K9/1623A61K9/1652A61K9/19A61K35/74A61K9/4825A61K9/4858A61K9/4866A61K9/4891A61K9/4816A23L33/135A61P1/00A61P1/04A61P13/00A61P13/02A61P13/04A61P13/12A61P15/08A61P19/06A61P25/02A61P29/00A61P3/00A61P9/00
Inventor KAUL, POONAMSIDHU, HARMEET
Owner OXTHERA INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap