Compositions comprising an aryl pyrazole and/or a formamidine, methods and uses thereof

Abstract

This invention relates to compositions for combating parasites in animals, comprising 1-arylpyrazole compounds alone or in combination with formamidine compounds. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infestation in an animal comprising administering the compositions of the invention to the animal in need thereof.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present application claims the benefit of priority to U.S. Provisional Application Nos. 61 / 116,038, filed Nov. 19, 2008; 61 / 142,561, filed Jan. 5, 2009; and 61 / 167,381, filed Apr. 7, 2009; the disclosures of which are all incorporated herein by reference in their entirety.INCORPORATION BY REFERENCE[0002]Any foregoing applications, and all documents cited therein or during their prosecution (“application cited documents”) and all documents cited or referenced in the application cited documents, and all documents cited or referenced herein (“herein cited documents”), and all documents cited or referenced in herein cited documents, together with any manufacturer's instructions, descriptions, product specifications, and product sheets for any products mentioned herein or in any document incorporated by reference herein, are hereby incorporated herein by reference, and may be employed in the practice of the invention. Reference is made to ...

AI Technical Summary

Benefits of technology

[0040]In some embodiments, the invention provides compositions and methods comprising at least one 1-arylpyrazole compound in a first veterinarily acceptable carrier and at least one formamidine compound in a second veterinarily acceptable carrier, where the compounds and veterinarily acceptable carriers are stored and administered from dual-cavity containers. The methods and compositions allow for stable synergistic compositions comprising 1-arylpyrazole compounds and formamidine compounds that have superior activity against parasites. In preferred embodiments, the 1-arylpyrazole compound is fipronil and the formamidine compound is amitraz. In some embodiments, the 1-arylpyrazole compound(s) and the corresponding carrier is administered simulta

Problems solved by technology

Animals such as mammals and birds are often susceptible to parasite infestations/infections.

Fleas are a particular problem because not only do they adversely affect the health of the animal or human, but they also cause a great deal of psychological stress.

Similarly, ticks are also harmful to the physical and psychological health of the animal or human.

However, the most serious problem associated with ticks is that they are the vector of pathogenic agents in both humans and animals.

Occasionally, these toxins are fatal to the host.

Moreover, mites and lice are particularly difficult to combat since there are very few active substances which act on these parasites and they require frequent treatment.

Likewise, farm animals are also susceptible to parasite infestations.

Ticks, such as Boophilus microplus, are particularly difficult to control because they live in the pasture where farm animals graze.

One problem associated with compositions comprising formamidine compounds, including amitraz, is the lack of long-term stability under certain conditions.

Therefore, although formamidine parasiticides, including amitraz, have considerable utility for treating and preventing parasitic infestat

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