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Method Of Preparing An Undifferentiated Cell

a technology of undifferentiated cells and stem cells, applied in the field of preparation of undifferentiated cells, can solve the problem that stem cells are extremely difficult to obtain from human patients

Inactive Publication Date: 2011-06-16
TRISTEM IRELAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The patent describes a method for converting differentiated cells back to an undifferentiated state, which can then be further differentiated into different cell types. This method can be used to obtain stem cells from more committed cells in the human body, which is difficult to do. The undifferentiated cells can also be pluripotent, meaning they can give rise to more than one cell lineage. This technique provides a powerful new method for obtaining stem cells and has important implications for regenerative medicine and cancer treatment."

Problems solved by technology

Stem cells are extremely difficult to obtain from human patients.

Method used

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  • Method Of Preparing An Undifferentiated Cell
  • Method Of Preparing An Undifferentiated Cell
  • Method Of Preparing An Undifferentiated Cell

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Embodiment Construction

I. Undifferentiated Cells and Differentiated Cell

[0089]There are many undifferentiated cells and differentiated cells found in vivo and the general art is replete with general teachings on them.

[0090]By way of example, with respect to cells of the haempoietic cell lineages, reference may be made to inter alia Levitt and Mertelsman 1995 (Haematopoietic Stem Cells, published by Marcel Dekker Inc—especially pages 45-59) and Roitt et al. (Immunology, 4th Edition, Eds. Roitt, Brostoff and Male 1996, Publ. Mosby—especially Chapter 10).

[0091]An undifferentiated cell is an immature cell that does not display a mature differentiated character but is capable of yielding progeny that do. A well-known example of an undifferentiated cell is a stem cell.

[0092]Stem cells are undifferentiated immature cells, capable of self renewal (division without limit) and differentiation (specialisation). These juvenile cells are abundant in a developing embryo, however, their numbers decrease as development p...

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Abstract

Disclosed is a method of preparing an undifferentiated cell. The method includes contacting a more committed cell with an agent that causes the more committed cell to retrodifferentiate into an undifferentiated cell.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a method of preparing an undifferentiated cell. In particular, the present invention relates to a method of preparing an undifferentiated cell from a more committed cell.[0002]In addition the present invention relates to the use of the undifferentiated cell of the present invention for the preparation of a new more committed cell—i.e. a recommitted cell.[0003]The present invention also relates to the use of the undifferentiated cell of the present invention or the recommitted cell of the present invention to have an effect (directly or indirectly via the use of products obtained therefrom) on the immune system, such as the alleviation of symptoms associated with, or the partial or complete cure from, an immunological condition or disease.BACKGROUND TO THE INVENTION[0004]Differentiation is a process whereby structures and functions of cells are progressively committed to give rise to more specialised cells, such as the form...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12N5/071C12N5/0735C12N5/0789A61K39/00A61K39/395A61P37/04C12N5/00C12N5/02C12N5/078
CPCC12N5/0634C12N2506/11C12N2501/50C12N2501/06A61P37/00A61P37/04C12N5/0602
Inventor ABULJADAYEL, ILHAM SALEH
Owner TRISTEM IRELAND
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