Methods of Treatment

a technology for diabetic conditions and nephrotic syndrome, applied in the field of treatment methods, can solve the problems of fatigue, edema, and people often gain weight, and achieve the effect of reducing hypertriglyceridemia and hypertriglyceridemia

Inactive Publication Date: 2011-12-08
CHUGH SUMANT S
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  • Abstract
  • Description
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Benefits of technology

[0066]In a seventh aspect, the present disclosure provides methods of reducing hypertriglyceridemia in a subject. In one embodiment, the subject is suffering from nephrotic syndrome. In one embodiment, the nephrotic syndrome is characterized as MCD, FSGS, MN/MGN, MPGN or diabetic nephropathy. In another embodiment, the nephrotic syndrome is characterized as MCD. In a specific embodiment, the hypertriglyceridemia is caused by hyposialylation of a polypeptide, such as, but not limited to, Angptl4. T

Problems solved by technology

When protein is lost in the urine, its blood concentration decreases, allowing water to move into other areas of the body, which leads to swelling known as edema.
Additionally, because of this extra fluid

Method used

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Embodiment Construction

[0072]In the following discussion certain articles and methods will be described for background and introductory purposes. Nothing contained herein is to be construed as an “admission” of prior art. Applicant expressly reserves the right to demonstrate, where appropriate, that the articles and methods referenced herein do not constitute prior art under the applicable statutory provisions.

[0073]While investigating the pathogenesis of nephrotic syndrome and proteinuria associated therewith, γ2-nephtotoxic serum (NTS, a serum raised against whole glomeruli), was injected into rats and a panel of differentially expressed glomerular genes was identified (7). Two genes not previously known to be involved in the pathogenesis of nephrotic syndrome and proteinuria were identified. One of these genes encoded for the transcriptional factor zinc fingers and homeoboxes 3 (ZHX3) expressed in podocytes, and has now been shown to play a key role in the pathogenesis of MCD (7). The second gene, angi...

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Abstract

The present disclosure provides a biochemical basis of nephrotic syndrome and provides and explanation for the observed proteinuria and other effects. As a result, the present disclosure provides method for treating and/or preventing nephrotic syndrome as well as methods of alleviating symptoms associated with nephrotic syndrome. The present disclosure further provides methods for reducing proteinuria in nephrotic syndrome and other disease states as discussed herein.

Description

STATEMENT AS TO FEDERALLY SPONSORED RESEARCH[0001]Funding for the work described herein was provided by the federal government, which has certain rights in the invention.FIELD OF THE DISCLOSURE[0002]The present disclosure is directed to methods for the treatment and prevention of nephrotic syndrome, diabetic conditions and conditions related thereto.BACKGROUND[0003]Nephrotic syndrome is caused by various disorders that damage the kidneys, particularly specialized cells called podocytes and the basement membrane of the glomerulus. Diabetic nephropathy and membranous glomerulonephritis (also called membranous nephropathy) are common causes in adults, whereas minimal change disease is the most common cause in children. Characteristics of nephrotic syndrome includes loss of protein in the urine (proteinuria), hyperlipidemia (hypercholesterolemia and hypertriglyceridemia), hypoalbuminemia (low blood albumin or protein levels) and edema. Proteinuria is defined as the presence of an excess...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61K31/7008G01N33/53A61P3/10A61P13/12
CPCA61K31/7008A61K31/7012G01N2800/56G01N2800/347G01N2800/52G01N2800/042A61P13/02A61P13/12A61P3/00A61P3/06A61P43/00A61P7/00A61P7/10A61P3/10C07K14/00C07K14/435
Inventor CHUGH, SUMANT S.
Owner CHUGH SUMANT S
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