Tissue pathlength resolved noninvasive analyzer apparatus and method of use thereof

a non-invasive, tissue pathlength technology, applied in the field of time-resolution gating non-invasive analyzer, can solve the problems of diabetes being the leading cause of death and disability worldwid

Inactive Publication Date: 2015-01-15
ZYOMED
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Problems solved by technology

Currently, diabetes is a leading cause of death and disability worldwide.

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  • Tissue pathlength resolved noninvasive analyzer apparatus and method of use thereof
  • Tissue pathlength resolved noninvasive analyzer apparatus and method of use thereof
  • Tissue pathlength resolved noninvasive analyzer apparatus and method of use thereof

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Embodiment Construction

[0025]The invention comprises a temporal resolution gating noninvasive analyzer apparatus and method of use thereof.

[0026]In one embodiment, a temporal resolution gating noninvasive analyzer is used to determine an analyte property of a biomedical sample, such as a glucose concentration of a subject using light in the near-infrared region from 1000 to 2500 nanometers.

[0027]In another embodiment, a data processing system analyzes data from an analyzer to estimate and / or determine an analyte property, such as concentration.

[0028]In still another embodiment, an analyzer using light interrogates the sample using one or more of:[0029]a spatially resolved system;[0030]a radial distance resolved system;[0031]a time resolved system, where the times are greater than about 1, 10, 100, or 1000 microseconds;[0032]a picosecond timeframe resolved system, where times are less than about 1, 10, 100, or 1000 nanoseconds;[0033]an incident angle resolved system; and[0034]a collection angle resolved sy...

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Abstract

An analyzer apparatus and method of use thereof is configured to dynamically interrogate a sample. For example, an analyzer using light interrogates a tissue sample using a temporal resolution system on a time scale of less than about one hundred nanoseconds. Optionally, near-infrared photons are introduced to a sample with a known illumination zone to detection zone distance allowing calculation of parameters related to photon pathlength in tissue and / or molar absorptivity of an individual or group through the use of the speed of light and / or one or more indices of refraction. Optionally, more accurate estimation of tissue properties are achieved through use of: knowledge of incident photon angle relative to skin, angularly resolved detector positions, anisotropy, skin temperature, environmental information, information related to contact pressure, blood glucose concentration history, and / or a skin layer thickness, such as that of the epidermis and dermis.

Description

CROSS REFERENCES TO RELATED APPLICATIONS[0001]This application claims the benefit of:[0002]U.S. provisional patent application No. 61 / 672,195 filed Jul. 16, 2012;[0003]U.S. provisional patent application No. 61 / 700,291 filed Sep. 12, 2012; and[0004]U.S. provisional patent application No. 61 / 700,294 filed Sep. 12, 2012,[0005]all of which are incorporated herein in their entirety by this reference thereto.TECHNICAL FIELD OF THE INVENTION[0006]The present invention relates to a temporal resolution gating noninvasive analyzer for use in analyte concentration estimation.DESCRIPTION OF THE RELATED ART[0007]Patents and literature related to the current invention are summarized herein.Diabetes[0008]Diabetes mellitus or diabetes is a chronic disease resulting in the improper production and / or use of insulin, a hormone that facilitates glucose uptake into cells. Diabetes is broadly categorized into four forms grouped by glucose concentration state: hyperinsulinemia (hypoglycemia), normal phys...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/1455A61B5/00A61B5/145
CPCA61B5/0022A61B5/14532A61B5/1455A61B5/6801A61B5/14552G01N2021/4742G01N2021/4747G01N2201/0826G01N21/474A61B5/1079G01J3/42
Inventor GULATI, SANDEEPGEORGE, THOMASRUCHTI, TIMOTHYABUL-HAJ, ALANHAZEN, KEVIN H.
Owner ZYOMED
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