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Tissue pathlength resolved noninvasive analyzer apparatus and method of use thereof

a non-invasive, tissue pathlength technology, applied in the field of time-resolution gating non-invasive analyzer, can solve the problems of diabetes being the leading cause of death and disability worldwid

Inactive Publication Date: 2015-01-15
ZYOMED
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent is about a machine and process for analyzing things non-invasively. The machine uses a special technique to measure the temperature of objects and can do so with high precision. This invention can help measure things more accurately and without damaging the object being analyzed.

Problems solved by technology

Currently, diabetes is a leading cause of death and disability worldwide.

Method used

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  • Tissue pathlength resolved noninvasive analyzer apparatus and method of use thereof
  • Tissue pathlength resolved noninvasive analyzer apparatus and method of use thereof
  • Tissue pathlength resolved noninvasive analyzer apparatus and method of use thereof

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Embodiment Construction

[0025]The invention comprises a temporal resolution gating noninvasive analyzer apparatus and method of use thereof.

[0026]In one embodiment, a temporal resolution gating noninvasive analyzer is used to determine an analyte property of a biomedical sample, such as a glucose concentration of a subject using light in the near-infrared region from 1000 to 2500 nanometers.

[0027]In another embodiment, a data processing system analyzes data from an analyzer to estimate and / or determine an analyte property, such as concentration.

[0028]In still another embodiment, an analyzer using light interrogates the sample using one or more of:[0029]a spatially resolved system;[0030]a radial distance resolved system;[0031]a time resolved system, where the times are greater than about 1, 10, 100, or 1000 microseconds;[0032]a picosecond timeframe resolved system, where times are less than about 1, 10, 100, or 1000 nanoseconds;[0033]an incident angle resolved system; and[0034]a collection angle resolved sy...

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Abstract

An analyzer apparatus and method of use thereof is configured to dynamically interrogate a sample. For example, an analyzer using light interrogates a tissue sample using a temporal resolution system on a time scale of less than about one hundred nanoseconds. Optionally, near-infrared photons are introduced to a sample with a known illumination zone to detection zone distance allowing calculation of parameters related to photon pathlength in tissue and / or molar absorptivity of an individual or group through the use of the speed of light and / or one or more indices of refraction. Optionally, more accurate estimation of tissue properties are achieved through use of: knowledge of incident photon angle relative to skin, angularly resolved detector positions, anisotropy, skin temperature, environmental information, information related to contact pressure, blood glucose concentration history, and / or a skin layer thickness, such as that of the epidermis and dermis.

Description

CROSS REFERENCES TO RELATED APPLICATIONS[0001]This application claims the benefit of:[0002]U.S. provisional patent application No. 61 / 672,195 filed Jul. 16, 2012;[0003]U.S. provisional patent application No. 61 / 700,291 filed Sep. 12, 2012; and[0004]U.S. provisional patent application No. 61 / 700,294 filed Sep. 12, 2012,[0005]all of which are incorporated herein in their entirety by this reference thereto.TECHNICAL FIELD OF THE INVENTION[0006]The present invention relates to a temporal resolution gating noninvasive analyzer for use in analyte concentration estimation.DESCRIPTION OF THE RELATED ART[0007]Patents and literature related to the current invention are summarized herein.Diabetes[0008]Diabetes mellitus or diabetes is a chronic disease resulting in the improper production and / or use of insulin, a hormone that facilitates glucose uptake into cells. Diabetes is broadly categorized into four forms grouped by glucose concentration state: hyperinsulinemia (hypoglycemia), normal phys...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/1455A61B5/00A61B5/145
CPCA61B5/0022A61B5/14532A61B5/1455A61B5/6801A61B5/14552G01N2021/4742G01N2021/4747G01N2201/0826G01N21/474A61B5/1079G01J3/42
Inventor GULATI, SANDEEPGEORGE, THOMASRUCHTI, TIMOTHYABUL-HAJ, ALANHAZEN, KEVIN H.
Owner ZYOMED
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