System and method for identifying behavioral signatures
a behavioral signature and behavioral technology, applied in the field of statistical grouping data, can solve the problems of complex exploratory behavior and endpoints that are far from suitable for best capturing the behavioral effect, and achieve the effects of broadening our understanding of the behavioral effects of drugs, maximizing behavioral properties, and high heritability behavior patterns
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8]Embodiment of the present invention screen a large number of complex behavior patterns in the output of a behavioral test and isolate a small set of patterns that maximize some desirable properties, such as discriminating between the experiment groups. Conventional tests for mouse and rat behavioral phenotyping typically export a small set (less than 100) of measures (“endpoints”) that are thought to be relevant for certain aspects of central nervous system (CNS) activity. For example, open-field and “locomotor behavior” tests typically export endpoints such as the distance traveled (“activity”, reflecting some type of “emotionality” and related to dopaminergic drugs) and the center time (thigmotaxis, reflecting relative anxiety). However, the performance of such endpoints (i.e., their ability to differentiate drugs, doses, genotypes, treatments, etc.) is generally very limited, and the results may be highly sensitive to confounding factors such as the laboratory or the experiment...
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