Composition for preventing and/or ameliorating cancer-related irreversible metabolism disorders

Abstract

[Problem] To provide a composition for preventing and / or ameliorating cancer-related irreversible metabolism disorders. [Solution] The present inventors have made intensive studies. As a result, it is found that a composition comprising, as essential components, a whey protein hydrolysate, lecithin and an oil or fat containing oleic acid both of which have a lipid metabolism improving activity and palatinose which has an insulin saving effect has an effect of preventing and / or ameliorating cancer-related irreversible metabolism disorders. This finding leads to the accomplishment of the present invention. Specifically, in an in vivo test using a model transplanted with tumor cells, it is found that this composition has an effect of preventing and / or ameliorating the decrease in muscle mass and the like, which are symptoms of cancer-related irreversible metabolism disorders, without inhibiting the activities of an anti-cancer agent.

Description

technical field

[0001] The present invention relates to a composition for preventing and / or improving irreversible metabolic disorder caused by cancer. Background technique

[0002] Cancer is the leading cause of death in Japan. In 2006, about 330,000 people died of cancer. Today, 1 out of every 2-3 people has the risk of being diagnosed with cancer in their lifetime (risk of disease), and there were about 590,000 new cancer patients in 2002 alone.

[0003] Most cancer patients are prone to malnutrition, and it can be determined that 60%-80% of cancer patients lose weight due to malnutrition. Known causes include poor oral intake due to cancerous lesions, neuropsychiatric changes, surgery, chemotherapy, radiotherapy, inappropriate nutritional management, irreversible metabolic disorders, etc. (Non-Patent Document 1). Once it falls into a state of irreversible metabolic disorder, it will lead to metabolic deterioration along with the development of cancer. For this reason,...

Examples

preparation example Construction

[0103] The preparation of the composition of the present invention can be carried out by methods known in the art. After mixing part or all of the above-mentioned raw materials, they are homogenized if necessary. The so-called homogenization means that the mixed ingredients are fully mixed and then evenly mixed, and the coarse particles of fat globules and other ingredients are mechanically refined to prevent the floating and coagulation of fats, etc., and make the composition appear Uniform emulsified state.

[0104] The preparation of the composition of the present invention requires heat treatment and heat sterilization. As the conditions for heat sterilization, normal food sterilization conditions can be used, and heat sterilization can be performed using a conventional device. For example, sterilization at 62-65°C for 30 minutes, 72°C or higher for 15 seconds or more, 72°C or higher for 15 minutes or more, or 120-150°C for 1-5 seconds, or 121-124°C for 5-20 minutes, 105...

Embodiment 1

[0142] [Effectiveness test using cancer cell transplantation experimental animals]

[0143] In the above Test Example 1, the effectiveness of the composition of the present invention was tested using experimental animals transplanted with cancer cells.

[0144] (Animal experiment)

[0145] Six-week-old male BALB / c rats were acclimatized for one week, and grouped according to the grouping structure recorded in Table 4 according to body weight.

[0146] 【Table 4】

[0147]

[0148] Colon26 cell line (rat colon cancer cell line, cancer research foundation) 1 × 10 6 The cells were transplanted subcutaneously into the axilla of each rat. Colon26 cell line was fed for 21 days after transplantation, dissected and blood was drawn to measure body weight, tumor weight, weight after tumor removal, fat mass (peritesticular fat), muscle mass (extensor digitorum longus), empty body mass, and blood Various indicators (PGE2, IL-6), the number of white blood cells in the whole blood, and...

technical field

[0001] The present invention relates to a composition for preventing and / or improving irreversible metabolic disorder caused by cancer. Background technique

[0002] Cancer is the leading cause of death in Japan. In 2006, about 330,000 people died of cancer. Today, 1 out of every 2-3 people has the risk of being diagnosed with cancer in their lifetime (risk of disease), and there were about 590,000 new cancer patients in 2002 alone.

[0003] Most cancer patients are prone to malnutrition, and it can be determined that 60%-80% of cancer patients lose weight due to malnutrition. Known causes include poor oral intake due to cancerous lesions, neuropsychiatric changes, surgery, chemotherapy, radiotherapy, inappropriate nutritional management, irreversible metabolic disorders, etc. (Non-Patent Document 1). Once it falls into a state of irreversible metabolic disorder, it will lead to metabolic deterioration along with the development of cancer. For this reason,...

Examples

preparation example Construction

[0103] The preparation of the composition of the present invention can be carried out by methods known in the art. After mixing part or all of the above-mentioned raw materials, they are homogenized if necessary. The so-called homogenization means that the mixed ingredients are fully mixed and then evenly mixed, and the coarse particles of fat globules and other ingredients are mechanically refined to prevent the floating and coagulation of fats, etc., and make the composition appear Uniform emulsified state.

[0104] The preparation of the composition of the present invention requires heat treatment and heat sterilization. As the conditions for heat sterilization, normal food sterilization conditions can be used, and heat sterilization can be performed using a conventional device. For example, sterilization at 62-65°C for 30 minutes, 72°C or higher for 15 seconds or more, 72°C or higher for 15 minutes or more, or 120-150°C for 1-5 seconds, or 121-124°C for 5-20 minutes, 105...

Embodiment 1

[0142] [Effectiveness test using cancer cell transplantation experimental animals]

[0143] In the above Test Example 1, the effectiveness of the composition of the present invention was tested using experimental animals transplanted with cancer cells.

[0144] (Animal experiment)

[0145] Six-week-old male BALB / c rats were acclimatized for one week, and grouped according to the grouping structure recorded in Table 4 according to body weight.

[0146] 【Table 4】

[0147]

[0148] Colon26 cell line (rat colon cancer cell line, cancer research foundation) 1 × 10 6 The cells were transplanted subcutaneously into the axilla of each rat. Colon26 cell line was fed for 21 days after transplantation, dissected and blood was drawn to measure body weight, tumor weight, weight after tumor removal, fat mass (peritesticular fat), muscle mass (extensor digitorum longus), empty body mass, and blood Various indicators (PGE2, IL-6), the number of white blood cells in the whole blood, and...

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