D-galactose addition feed for constructing senile dementia animal model and preparation method thereof

Abstract

The invention discloses a D-galactose addition feed for constructing a senile dementia animal model and a preparation method thereof, and relates to the technical field of construction of a medical experimental animal model. The preparation method comprises the steps of: weighing corn oil and anhydrous milk fat according to a proportion and heating and melting the corn oil and the anhydrous milk fat into a semi-fluid state grease material; then re-weighing raw materials: casein, corn starch, maltodextrin, cane sugar, cellulose, DL-methionine, D-galactose, composite minerals, calcium carbonate, composite vitamins and choline bitartrate; mixing the weighed raw materials, and preparing feed particles with a diameter of 10mm and a length of 15-20mm by using a hoop standard granulator; performing dehumidification and drying for 24-36 hours again through a dehumidifier, finally obtaining dried feed particles; and packing products, carrying out irradiation and disinfection by using cobalt 60, and obtaining finished products. The D-galactose addition feed for constructing a senile dementia animal model has stable nutrient composition and meets the hardness and mouthfeel of eating habits of rodents. The process is simple and the molding effect is good.

Description

technical field

[0001] The invention relates to the technical field of building animal models for medical experiments, and relates to a D-galactose-added feed for building an animal model of senile dementia and a preparation method thereof. Background technique

[0002] Senile dementia (Alzheimers disease, AD), also known as Alzheimer's disease, is a group of primary degenerative brain degenerative diseases of unknown etiology; it mostly occurs in old age, with latent onset, slow and irreversible course, clinical It is characterized by progressive memory impairment and loss of acquired knowledge; the pathological changes are mainly diffuse cortical atrophy, widened sulci, enlarged ventricles, a large number of neurons, and senile plaques, neurofibrillary knots and other lesions can be seen, choline acetyl The content of catalase and acetylcholine was significantly reduced. Epidemiological surveys found that the prevalence rate among the 60-90-year-old population increases e...

Examples

preparation example Construction

[0047] Its preparation method comprises the following steps:

[0048] 1), raw material pretreatment,

[0049] First, weigh 1% to 5% of corn oil and 2% to 6% of anhydrous milk fat, heat the corn oil and anhydrous milk fat to 70-80°C to melt, add 3% to 10% of the total weight of raw materials in water, and stir well , in a semi-fluid state; stand-by;

[0050] Weigh raw materials according to the proportion: casein, corn starch, maltodextrin, sucrose, cellulose, DL-methionine, D-galactose, complex minerals, calcium carbonate, multivitamins and choline bitartrate;

[0051] 2), prepare the mixture,

[0052] Mix the weighed raw materials, stir evenly, add the above semi-fluid fat, and continue mixing for 2 to 4 minutes;

[0053] 3), prepare the product,

[0054] At 20-30°C, feed pellets with a diameter of 10mm and a length of 15-20mm are produced by a ring die pellet machine; at 20-25°C, the feed pellets are dehumidified and dried for 24-36 hours through a dehumidifier, and fina...

specific Embodiment 1

[0058] 1), raw material pretreatment,

[0059] First, weigh the materials in the raw materials: 1% corn oil, 2% anhydrous milk fat, heat the corn oil and anhydrous milk fat to 70°C to melt, add the total weight of the raw materials to the heated and melted corn oil and anhydrous milk fat mixture 3% water, stir evenly to form a semi-fluid fat material; set aside;

[0060] Weigh other materials in raw materials according to the proportion: 20% casein, 15% corn starch, 10% maltodextrin, 20% sucrose, 5% cellulose, 0.1% DL-methionine, 0.02% D-galactose, compound mineral Substance 0.5%, calcium carbonate 0.1%, multivitamin 0.5% and choline bitartrate 0.2%;

[0061] 2), prepare the mixture,

[0062] Mix the weighed raw materials, stir evenly, add the above semi-fluid fat, and continue mixing for 2 to 4 minutes;

[0063] 3), prepare the product,

[0064] At 20-30°C, feed pellets with a diameter of 10mm and a length of 15-20mm are produced by a ring die pellet machine; at 20-25°C, ...

specific Embodiment 2

[0068] 1), raw material pretreatment,

[0069] First, weigh the materials in the raw materials: 3% corn oil, 4% anhydrous milk fat, heat the corn oil and anhydrous milk fat to 75°C to melt, add the total weight of the raw materials to the heated and melted corn oil and anhydrous milk fat mixture 6.5% water, stir evenly to form a semi-fluid fat; set aside;

[0070] Weigh other materials in raw materials according to the proportion: 25% casein, 22.5% corn starch, 15% maltodextrin, 25% sucrose, 7.5% cellulose, 0.3% DL-methionine, 0.06% D-galactose, compound mineral Substance 2%, calcium carbonate 0.3%, multivitamin 1.75% and choline bitartrate 0.6%;

[0071] 2), prepare the mixture,

[0072] Mix the weighed raw materials, stir evenly, add the above semi-fluid fat, and continue mixing for 2 to 4 minutes;

[0073] 3), prepare the product,

[0074] At 20-30°C, feed pellets with a diameter of 10mm and a length of 15-20mm are produced by a ring die pellet machine; at 20-25°C, the ...

technical field

[0001] The invention relates to the technical field of building animal models for medical experiments, and relates to a D-galactose-added feed for building an animal model of senile dementia and a preparation method thereof. Background technique

[0002] Senile dementia (Alzheimers disease, AD), also known as Alzheimer's disease, is a group of primary degenerative brain degenerative diseases of unknown etiology; it mostly occurs in old age, with latent onset, slow and irreversible course, clinical It is characterized by progressive memory impairment and loss of acquired knowledge; the pathological changes are mainly diffuse cortical atrophy, widened sulci, enlarged ventricles, a large number of neurons, and senile plaques, neurofibrillary knots and other lesions can be seen, choline acetyl The content of catalase and acetylcholine was significantly reduced. Epidemiological surveys found that the prevalence rate among the 60-90-year-old population increases e...

Examples

preparation example Construction

[0047] Its preparation method comprises the following steps:

[0048] 1), raw material pretreatment,

[0049] First, weigh 1% to 5% of corn oil and 2% to 6% of anhydrous milk fat, heat the corn oil and anhydrous milk fat to 70-80°C to melt, add 3% to 10% of the total weight of raw materials in water, and stir well , in a semi-fluid state; stand-by;

[0050] Weigh raw materials according to the proportion: casein, corn starch, maltodextrin, sucrose, cellulose, DL-methionine, D-galactose, complex minerals, calcium carbonate, multivitamins and choline bitartrate;

[0051] 2), prepare the mixture,

[0052] Mix the weighed raw materials, stir evenly, add the above semi-fluid fat, and continue mixing for 2 to 4 minutes;

[0053] 3), prepare the product,

[0054] At 20-30°C, feed pellets with a diameter of 10mm and a length of 15-20mm are produced by a ring die pellet machine; at 20-25°C, the feed pellets are dehumidified and dried for 24-36 hours through a dehumidifier, and fina...

specific Embodiment 1

[0058] 1), raw material pretreatment,

[0059] First, weigh the materials in the raw materials: 1% corn oil, 2% anhydrous milk fat, heat the corn oil and anhydrous milk fat to 70°C to melt, add the total weight of the raw materials to the heated and melted corn oil and anhydrous milk fat mixture 3% water, stir evenly to form a semi-fluid fat material; set aside;

[0060] Weigh other materials in raw materials according to the proportion: 20% casein, 15% corn starch, 10% maltodextrin, 20% sucrose, 5% cellulose, 0.1% DL-methionine, 0.02% D-galactose, compound mineral Substance 0.5%, calcium carbonate 0.1%, multivitamin 0.5% and choline bitartrate 0.2%;

[0061] 2), prepare the mixture,

[0062] Mix the weighed raw materials, stir evenly, add the above semi-fluid fat, and continue mixing for 2 to 4 minutes;

[0063] 3), prepare the product,

[0064] At 20-30°C, feed pellets with a diameter of 10mm and a length of 15-20mm are produced by a ring die pellet machine; at 20-25°C, ...

specific Embodiment 2

[0068] 1), raw material pretreatment,

[0069] First, weigh the materials in the raw materials: 3% corn oil, 4% anhydrous milk fat, heat the corn oil and anhydrous milk fat to 75°C to melt, add the total weight of the raw materials to the heated and melted corn oil and anhydrous milk fat mixture 6.5% water, stir evenly to form a semi-fluid fat; set aside;

[0070] Weigh other materials in raw materials according to the proportion: 25% casein, 22.5% corn starch, 15% maltodextrin, 25% sucrose, 7.5% cellulose, 0.3% DL-methionine, 0.06% D-galactose, compound mineral Substance 2%, calcium carbonate 0.3%, multivitamin 1.75% and choline bitartrate 0.6%;

[0071] 2), prepare the mixture,

[0072] Mix the weighed raw materials, stir evenly, add the above semi-fluid fat, and continue mixing for 2 to 4 minutes;

[0073] 3), prepare the product,

[0074] At 20-30°C, feed pellets with a diameter of 10mm and a length of 15-20mm are produced by a ring die pellet machine; at 20-25°C, the ...

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