4 results about "Anti-diabetic Agent" patented technology

The invention discloses a 5-(2-nitrophenyl)-2-phenyl-1, 10b-dihydro-5H-benzo [e] pyrazolo [1, 5-c] [1, 3] oxazine compound and application of the 5-(2-nitrophenyl)-2-phenyl-1, 10b-dihydro-5H-benzo [e] pyrazolo [1, 5-c] [1, 3] oxazine compound in a medicine for treating diabetes mellitus. The compound as shown in the following formula (1) is obtained through virtual screening in combination with experimental verification, and the compound has remarkable alpha-glucosidase inhibitory activity. In-vitro and in-vivo experiments prove that the compound effectively reduces the generation of glucose and delays the digestion and decomposition of starch by inhibiting the activity of alpha-glucosidase. The invention discloses the compound and the application thereof in the field of preparation of anti-diabetic drugs for the first time, the alpha-glucosidase inhibitory activity of the compound is high, and a new direction is provided for development of diabetes treatment drugs. Formula (1) below

Provided herein are insulin receptor (INSR) agonists compounds of Formula I-IV or compositions containing the compounds, the use of these compounds or compositions in the treatment of diabetes. The compounds and compositions can bind to the allosteric sites on INSR and activate INSR and downstream signaling pathways synergistically with insulin by phosphorylating INSR proteins.

The present invention discloses a compound with endoplasmic reticulum targeting and its application. The compound has the following chemical formula: #imgabs0# The compound provided by the present invention has good endoplasmic reticulum targeting and the ability to induce the production of type I reactive oxygen species. In addition, the compound can induce time-dependent depletion of endoplasmic reticulum calcium in cancer cells under light conditions. More importantly, the existing anti-diabetic drug glibenclamide closes the ATP-dependent potassium ion channel (K) on the endoplasmic reticulum membrane. + ATP ), the compound-induced loss of endoplasmic reticulum calcium into the cytoplasm will lead to severe depolarization of the endoplasmic reticulum membrane potential, and ultimately activate the downstream endoplasmic reticulum and mitochondria-dependent apoptosis pathways, leading to cancer cell death, while also embodying the new use of glibenclamide.

The application discloses a natural alpha-glucosidase inhibitor and a preparation method and application thereof, and the natural alpha-glucosidase inhibitor is 3,3'-dimethoxy ellagic acid extracted from a sapium sebiferum. The application is specifically implemented according to the following steps: preparing a sapium sebiferum extract; and separating and purifying the sapium sebiferum extract to obtain 3,3'-dimethoxy ellagic acid. The application obtains a novel natural alpha-glucosidase inhibitor 3,3'-dimethoxy ellagic acid, and the inhibition effect of the 3,3'-dimethoxy ellagic acid on alpha-glucosidase is obvious at a concentration of 4 mg / mL, so that the 3,3'-dimethoxy ellagic acid provides a lead compound for research and development of a novel natural anti-diabetic drug.