4 results about "Bile-acid Binding Resin" patented technology

Pharmaceutical compositions comprising bile acid sequestrants, their use in treating bile acid malabsorption, and associated conditions such as bile acid diarrhea and colitis are described herein. Methods for treating bile acid malabsorption and associated conditions are also described.

Provided are methods of treating subjects in need of an anti-fibroblast growth factor receptor 3 (anti-FGFR3) therapy. The methods comprise administering to the subjects a therapeutically effective amount of a peroxisome proliferator-activated receptor (PPAR) alpha agonist in combination with the anti-FGFR3 therapy. The methods can comprise administering to the subject a therapeutically effective amount of PPAR alpha agonist and a bile acid sequestrant. Also provided are compositions comprising an FGFR3 inhibitor, a PPAR alpha agonist, and, optionally, a bile acid sequestrant. The methods attenuate the dysregulation of bile acid biosynthesis caused by FGFR3 inhibition with anti-FGFR3 therapies. The methods reduce the severity and / or incidence of adverse events associated with anti-FGFR3 therapies.

The invention relates to the technical field of food and feed additives, and discloses application of a tea polyphenol preparation in reduction of egg cholesterol. The tea polyphenol preparation comprises high-purity tea polyphenol, a phospholipid complex, phytosterol, bile acid binding resin and a microcapsule wall material. By limiting the purity and component composition of tea polyphenol, a phospholipid-mediated nano delivery system is constructed, a dual mechanism of bile acid adsorption and phytosterol competitive absorption is introduced, and the stability of active components in the feed processing and digestion process is guaranteed by adopting a microcapsule technology; the technical scheme which is definite in component, clear in action path, convenient to use and repeatable in effect is formed, the defects that in the prior art, multiple components are mixed, the mechanism is unknown, operation is tedious, raw materials are limited and the like are effectively overcome, and reliable technical support is provided for industrial production of the low-cholesterol functional eggs.

The present disclosure provides a combination of a liposomal suspension, and of albumin, for use as bile acid sequestrants, wherein the use comprises (a) intraperitoneally administering the liposomal suspension to a subject in need thereof; and (b) intravenously or intraperitoneally administering the albumin to the subject; and (c) removing a dialysate containing liposomes and at least one bile acid from the subject, wherein the at least one bile acid comprises cholic acid, glycocholic acid, glycochenodeoxycholic acid or a combination of at least two thereof.