3 results about "Liver support systems" patented technology

A bioartificial liver support system for continuous and discontinuous procedures to provide liver support to a patient, comprising: a chamber containing biomass; a tubular system having multiple circuits adapted to provide independent circuit operation to an apheresis machine or patient; and a monitoring device having one or more sensors adapted to collect, record, analyze, download, and / or store data from the system.

The invention provides a bioartificial liver supporting system which at least comprises a blood input branch pipeline, a plasma separation branch pipeline, a biological purification branch pipeline and a plasma return branch pipeline which are connected in sequence, and a liquid separation bottle is arranged between the biological purification branch pipeline and the plasma return branch pipeline; the liquid separation bottle comprises a bottle body, at least three partition plates are arranged in the bottle body, the heights of the partition plates are sequentially reduced in the circumferential direction so that the interior of the bottle body can be at least divided into three chambers with the water level heights sequentially reduced in the circumferential direction, the biological purification branch pipeline is communicated with the chamber with the highest water level height, and the slurry return branch pipeline is communicated with the chamber with the lowest water level height. According to the bioartificial liver supporting system, the liquid separation bottle is arranged, and the water level height difference of the multiple chambers formed in the liquid separation bottle is utilized, so that seed cells and cell debris contained in blood plasma are deposited, the situation that the seed cells and the cell debris are infused back into the body of a patient along with the blood plasma to cause discomfort of the patient is avoided, and the use safety of the bioartificial liver supporting system is improved.

The present disclosure relates to a liver support system comprising (a) a single mining column; and (b) a detoxification column comprising a plurality of liver tissues, wherein the liver support system is configured to allow fluid to flow from the apheresis column to the detoxification column. The detoxification column can provide detoxification, secretion and regeneration functions. The detoxification may include promotion of severely impaired central urea cycle as well as CYP function that is crucial for detoxification of exogenous materials, cellular metabolism, and homeostasis. The single sampling column can play a role in adsorbing granulocytes from fluid and protecting a plurality of liver tissues from inflammatory injury. The present disclosure relates to methods of using a liver support system and engineered cells for use in a liver support system.