126results about How to "Promote learning and memory" patented technology

The tubiflorous desert cistanche preparation containing phenethyl alcohol glycoside contains echinacoside in 10-70 wt% and acteoside in 1-40 wt%. The preparation of the present invention may be applied as active component for preparing medicine treating and preventing senile dementia and for preparing medicine inhibiting platelet aggregation.

The invention belongs to the field of pharmacy, and relates to application of a hydrogen sulfide donor to the preparation of a medicine for treating central nervous system disease, in particular to application of the hydrogen sulfide donor, namely sodium hydrosulfide, or allyl cysteine and analogues thereof to the preparation of the medicine for treating the central nervous system disease. Integral animal model experiments prove that the sodium hydrosulfide and propargyl cysteine can reduce the learning and memory impairment of rats, increase the content of hydrogen sulfide in hippocampus tissues of the rats, inhibit the messenger ribonucleic acid (mRNA) expression of a tumor necrosis factor alpha and a receptor I thereof, inhibit an inflammatory mediator in the hippocampus tissues of rats with dementia and inhibit inflammation-related enzymes in the hippocampus tissues of the rats, and can be used as a medicine for treating Alzheimer disease and other inflammation-related central nervous system degenerative diseases such as Parkinson disease.

The invention provides a method for preparing a 5,6,7,4'-tetrahydroxyflavone compound, which is characterized by comprising the following steps: taking breviscapinun as a raw material, and performing heating reflux reaction between the breviscapinun and alcohol under the catalysis of acid, namely adding 200 to 500 ml of alcohol substance and 1 to 3 ml of 4 to 5 percent acid into 12 to 20 g of the breviscapinun for the heating reflux reaction; and filtering a product, and drying to a constant weight to obtain 5,6,7,4'-tetrahydroxyflavone shown in a formula I. Experiments prove that the 5,6,7,4'-tetrahydroxyflavone shows obvious strengthening effect on acquisition, consolidation and representation of brain memory of a mice model of alzheimer disease, has obvious improving effect on learning memory of the mice model with memory loss caused by anisodine of an M-cholinergic inhibitor, and can obviously improve the recent memory and long-term memory capacities of mice. The experiments also prove that the 5,6,7,4'-tetrahydroxyflavone has the effect of treating arthritis, and also has good treating effects on diabetes mellitus and osteoporosis.

The invention discloses a refreshing anti-fatigue solid beverage. The solid beverage is prepared from the following raw materials: plant extract, a sweetening agent, an acidity regulator, a nutrient supplement, maltodextrin, plant protein peptide powder and mixed-fruit flavored essence. The preparation process of the solid beverage comprises the steps of inspecting raw materials, preparing materials, mixing materials, sterilizing, quantitatively packaging, inspecting, filling into cartons and storing. The refreshing anti-fatigue solid beverage has rich nutrition and good refreshing and anti-fatigue effect by adding multiple plant extracts, is easy to prepare and convenient to carry, is especially suitable for people who operate computers for a long time, drivers and students. The solid beverage further contains electrolyte, can be taken by sporting groups to keep homeostasis and regulate muscle contraction, and cannot cause nausea, headache and other situations.

A snuff for preventing and treating senile dementia, improving memory and regulating the permeability of blood brain barrier is prepared from the active component(s) chosen from eugenol, its salt, its isomer and their mixture, and selective natural spice.

The present invention provides the extraction of wild jujube seed oil, the preparation of soft capsule and the function on central nervous system. The extraction of wild jujube seed oil includes squeezing wild jujube seed in squeezer to obtain dregs and coarse oil; mixing the dregs and petroleum ether to obtain refined oil after recovering petroleum ether; dissolving the coarse oil and petroleum ether to obtain refined oil after recovering petroleum ether; merging refined oil, heating in evaporating pot to eliminate residual solvent and water and to obtain wild jujube seed oil. The preparation of soft wild jujube seed oil capsule includes soaking gelatin, heating in water bath, adding glycerin and Nipagin A, and filtering to obtain gelatin liquid; preparing gelatin plate with the gelatin liquid; sandwiching wild jujube seed oil with two gelatin plates and pressing with steel mold. Research shows that wild jujube seed oil has tranquilizing, hypnotic, memory-promoting and anxiety resisting effects, and may be used in treating neurosis and insomnia.

A Chinese-character "pronunciation-shape" input method is cahracterized by that the particular radicals are assigned to 26 English letter keys of keyboard to form the shape codes and the phonetic letters codes, which are combined to become code cell. Its input steps include inputting phonetic letter codes, and inputting the first phonetic letter of its radical.

The invention discloses the preparation and application of flavonol as a brain-targeting synergist. In a long-term experimental study, the inventor finds that parts of flavonol compounds, particularly kaempferide, rutin, troxerutin, myricetin and aurantiamarin, and the hydroxy ether derivatives of the flavonol compounds, particularly glucoside, ester and ether derivatives of the flavonol compounds, can well promote medicine molecules, such as ginsenoside, stilbeneglycoside, resveratrol, levodopa, edaravone, vinpocetine, nicergoline, citicoline and oxiracetam, which have treatment or healthcare functions on cerebral diseases, to enter brain tissues, so that the concentration of the medicine molecules in the brain tissues is greatly increased without increasing the blood concentration, and the curative effect of medicine is effectively promoted.

The present invention relates to a phosphodiesterase 4 inhibitor capable of avoiding vomiting. The phosphodiesterase 4 inhibitor is a compound, a prodrug or a solvate represented by DTPM; and the DTPM is named as 1-(4-difluoro methoxy-3-(tetrahydrofuran-3-oxyl) phenyl)-3-dimethyl-1-ketone, and has a chemical formula shown as below. A plurality of experiments have proved that the DTPM has better effect on improvement of learning and memory compared with an existing antidepressant PDE4 inhibitor; in a Beagle dog vomiting effect observation experiment, no obvious vomiting inducing reaction is observed; and the DTPM has an inhibitor intensity 5000 times of that of other PDE4D families. The inhibitor provided by the invention can become a drug for treating depression and Alzheimer's disease and improving the cognitive ability, and capable of effectively reducing and even avoiding adverse reactions like vomiting.

The invention discloses a compound gardenia oil soft capsule and a method for preparing the same. The gardenia oil soft capsule is used for treating insomnia and consists of a content and rubber sheet, wherein the content consists of clear spina date seed oil, clear semen boitae oil and clear gardenia oil according to a mass ratio of 3:2-3:1-1.5, and the rubber sheet consists of a rubber material, humectant, water and antiseptic according to a mass ratio of 10:4-6:7-14:0.005. The clear spina date seed oil, the clear semen boitae oil and the clear gardenia oil are mixed uniformly to form the content; the water is heated and added sequentially with the humectant, the antiseptic and the rubber material to form a gum-solution; the content and the gum-solution are pressed by the prior pressing method so as to be formed; and after post treatment, the compound gardenia oil soft capsule is obtained. The compound gardenia oil soft capsule is reasonable in formula, has a sedative-hypnotic function which can be enhanced by long drug application time, is free from tolerance and suitable to be used for treating insomnia, and can relieve physical fatigue.

A Chinese medicine in the form of particle for treating the minimal brani dysfunction (MBD) of children is prepared from 11 Chinese-medicinal materials including rehmannia root, white peony root, ophiopogon root, pilose osiabell root, etc.

The invention relates to the use of Hypericum seniawinii Maxim. or its extract in preparing medicament or food for resisting depression, enhancing intelligence or/and reducing-fat, experiment shows that, the Hypericum seniawinii Maxim. or its extracts can be used as the active constituents for preparing medicament for the treatment of depression, dyssomnia, senile dementia, hypomnesis and obesity, or used as food extender or food additive in preparing food for antisenescence and fat-reducing.

The invention discloses a method for preparing total salvianolic acid. The method comprises the following steps of extracting Salvia miltiorrhiza by water-containing low-grade alcohol and extracting headspace polyamide or separating macroporous resin. The method has the advantages that the transferring rate of salvianolic acid B is high and can achieve 50-60%; the loss of active ingredients is low, the quality of the prepared product is good, the content of the total phenolic acid is equal to or greater than 80%, the content of salvianolic acid B is equal to or greater than 50%, and the therapeutic effect is obvious. The invention also discloses a preparation on pharmacy and a preparing purpose thereof.

The invention discloses a Chinese medicinal composition, its preparing process and use, wherein the preparing process consists of watering and grilling Ligusticum wallichii, root of red rooted saliva, zedoary, peach kernels and common burreed tuber three times (1-3 hours each time), merging the grilling liquids, concentrating into concrete with specific gravity of 1. 10-1. 30 (60 deg C. ), disintegrating safflower and earthworm into fine powders, charging musk and pharmaceutically acceptable medicinal auxiliary materials, and mixing with the concrete homogeneously. The composition can be used for treating cerebral embolism, arteriosclerosis, coronary disease, senile dementia, light-headedness, hemiparalysis, brain trauma and cerebral hemorrhage sequelae.

The invention relates to application of N-(3- pyridine formex oxygen radical)-3, 5- dimethyl-1- amantadine or pharmaceutically-acceptable salt for treating vascular dementia.

Disclosed are: a novel substance having a cerebral nerve cell neogenesis effect; and a cerebral nerve cell neogenesis agent which comprises the substance and is effective for the treatment and/or prevention of nerve diseases. Specifically disclosed is a cerebral nerve cell neogenesis agent comprising a plasmalogen as an active ingredient. Particularly, a cerebral nerve cell neogenesis agent comprising, as an active ingredient, a plasmalogen extracted from a biological tissue (preferably an avian tissue) that mainly contains ethanolamine plasmalogen and choline plasmalogen is preferred.

The present invention discloses application of bilobalide as a synergist in preparation of a drug or a heath product for preventing cranial nerve injury diseases. An inventor discovers that compounds of bilobalides, particularly bilobalide, bilobalide extracts, and hydroxyl derivatives of bilobalides, particularly glucoside derivatives, ester derivatives and ether derivatives can well promote drug molecules with a treating or health care function on cranial nerve injury diseases to enter brain tissues, wherein the drug molecules comprise ginsenoside, stibene glucoside, resveratrol, levodopa, edaravone, vinpocetine, nicergoline, citicoline, oxiracetam and the like; under the conditions of not increasing drug concentration in blood, the concentration of bilobalide can be increased to a large extent in the brain tissues, so that the efficacy of the drug can be improved, and side effects and adverse reactions of the drug can be reduced.

The invention discloses an asarum sagittarioides intelligence-improving functional beverage and a preparation method thereof. The asarum sagittarioides intelligence-improving functional beverage comprises following components in parts by weight: 0.1-90 parts of fresh needle mushrooms, 0.1-90 parts of fresh Chinese yams, 0.1-20 parts of cornus officinalis, 0.1-20 parts of poria cocos, 0.2-40 parts of walnut kernels, 0.1-20 parts of black sesames, 0.2-40 parts of black soybeans, 0.1-20 parts of prepared rehmannia roots, 0.1-20 parts of lilies, 0.1-20 parts of platycladi seeds, 0.1-20 parts of spina date seeds, 0.1-20 parts of lotus seeds, 0.1-20 parts of mulberries, 0.1-20 parts of longan pulp and 0.1-20 parts of red dates; the raw materials are prepared into needle mushroom medical raw juice; L-lysine hydrochloride, zinc gluconate, taurine, maltitol, sucralose, sucrose fatty acid ester, glycerol monostearate, sodium alginate, xanthan gum, sodium carboxymethylcellulose, sodium tripolyphosphate, sodium isoascorbate, nisin and the like are added to be uniformly agitated; pure water is added to dilute to prepare the product. The asarum sagittarioides intelligence-improving functional beverage has five effects of improving the study memory, beautifying, adjusting the blood lipids, softening the angiocarpy and delaying aging; the immunity of people is improved and the physique is enhanced. The asarum sagittarioides intelligence-improving functional beverage is pleasant to the palate, has a smooth and fine mouth feel and has a unique flavor.

The invention provides a sulfydryl-containing tacrine compound or a dynamic isomer or a medicinal salt thereof. The compound or the dynamic isomer or the medicinal salt thereof have the functions of suppressing acetylcholine esterase, enhancing sea horse LTP (Long-Term Potentiation) and improving learning and memory, and can be used for treating, improving or preventing cognitive function decline-related neurous system diseases such as the Alzheimer's disease, vascular dementia, mild cognitive impairment and other oxidative stress participated dementia.

The invention provides a brain tonic medicament which comprises the following raw materials (by weight portion): gastrodia elata 20-90 parts, notoginseng 5-40 parts, ginkgo leaf 5-30 parts, walnut kernel 0-30 parts, ophiopogon root 5-50 parts, ichih fruit 5-40 parts and schisandra fruit 5-60 parts.

The invention relates to a composition comprising ginsenoside Rg1 and caffeine with antifatigue, memory improving and central exciting effects and an application thereof. The composition comprises the following raw ingredients (wt %): ginsenoside Rg1 1-99 and caffeine 99-1. The reasonable formula of ginsenoside Rg1 and caffeine overcomes the shortcoming of caffeine that can only resist short-term sports fatigue, and takes synergistic antifatigue, memory improving and central exciting effects. The inventive composition can be mixed with proper pharmaceutical or food adjutants to prepare into pharmaceutically-acceptable preparations or food preparations.

The invention provides a Chinese medicinal composition for treating cerebral apoplexy, wherein the active constituents of the composition comprises (by weight ratio): acorus gramineus soland 50-500, rhizome of Sichuan lovage 50-500, borneol 1-10.

The invention relates to a baicalin and taurine medicinal composition capable of protecting neurocyte injury, improving the learning and memory ability and improving the cognition impairment so as to prevent and treat dementia.

The invention discloses a spica prunellae extract, and a preparation method and application thereof. The weight percentage of caffeic acid in the spica prunellae extract is greater than or equal to 5 percent; the weight percent of rosmarinic acid is greater than or equal to 15 percent. The preparation method of the spica prunellae extract provided by the invention is simple, convenient and practical; the operation is easy; the spica prunellae extract is more suitable for industrial production; in addition, the extract has an improving effect on the study and memory of fast-aging model rats due to D-galactose; the escape latency period and the platform passing times of the fast-aging model rats in the water maze tests can be reduced; immunohistochemical results show that the extract can reduce the hippocampal CA1 area Caspase-3 and cerebral cortex GFAP expression of the fast-aging model rats. HE and Nissl dyeing results show that the extract can relieve the neuron injury due to the D-galactose. The condition that the spica prunellae extract has the effect of resisting Alzheimer's diseases is discovered; the spica prunellae extract is applied to the preparation of medicines for resisting the Alzheimer's diseases and for treating senile dementia.

The invention discloses application of mental treasure pills in preparation of a medicine for treating senile dementia. Due to the improvement effect of the mental treasure pills on mouse reproduction memory disorder caused by scopolamine and mouse memory consolidating hinder caused by NaNO2 and mouse reproduction memory disorder caused by ethanol through a step-down test and a Morris water maze test, the mental treasure pills have a certain effect of improving the learning and memory. In addition, the Morris water maze test of APP/PSI double transgenic mice further proves that the mental treasure pills have a certain effect of improving the dysmnesia. The experimental result proves that the mental treasure pills can be used for preparing the medicine for treating senile dementia and have the characteristics of stable curative effect, medication safety, low toxic-side effect, low price and the like.

The invention relates to a compound black garlic preparation and aims to provide a new traditional Chinese medicine which includes black garlic, scrophularia henryi and gingko leaves. The compound black garlic preparation has the effects of improving study and memory functions and includes a black garlic extract, a scrophularia henryi extract and a gingko leaf extract according to the mass ratio of 8-12:2-4:4-6, and also includes an auxiliary material accounting for 0.1-1% of the total mass. The black garlic extract, the scrophularia henryi extract and the gingko leaf extract are all powders obtained by sieving through an 80-mesh sieve. The black garlic extract is extracted through an extracting agent of 75% ethanol, the scrophularia henryi extract is extracted through water-saturated n-butyl alcohol, and the gingko leaf extract is an ethanol extract prepared by crushing gingko and performing macroporous resin adsorption. The mass ratio of the black garlic extract, the scrophularia henryi extract and the gingko leaf extract is 9-11:2.5-3.5:4.5-5.5.