The invention discloses a regional management and 
control system based on EM + RFID and an anti-theft method of an 
access control system thereof, and belongs to the field of secret storage. The systemcomprises an EM + RFID confidential medium storage cabinet used for storing confidential articles pasted with EM + RFID passive tags, a portable RFID 
card reader used for identifying a 
label on a secret-related article, an entrance guard 
system used for identifying whether a person entering and exiting an area carries an EM medium or a secret-related article pasted with an EM + RFID passive tag or not; and an EM + RFID management and 
control system software platform used for communicating with the EM + RFID secret medium storage cabinet, the portable RFID 
card reader and the entrance guard 
system, and realizing 
data synchronization and managing the regional management and 
control system. According to the system, an EM + RFID double-frequency technology is used as a means for regional management and control. The EM can perfectly overcome the defects that the RFID is reflected by 
metal and shielding cloth and absorbed by a 
human body and water, the EM belongs to a magnetic medium, the 
frequency band anti-interference capacity is high, the RFID is not prone to being shielded and after being washed, the monitoring rate can reach 99.9% through 
processing of an amplifying circuit, and the management capacity of a confidential medium is greatly improved.