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Gelatin for preventing conglutination in the surgical and the method for preparing the same

A surgical operation and anti-adhesion technology, which is applied in the direction of surgical drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of difficult control of purity and degradation speed, non-degradable absorption, and tissue stimulation, etc., to achieve excellent Bio-barrier properties, easy absorption by the body, and the effect of preventing tissue adhesion

Inactive Publication Date: 2009-05-27
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the first and second generation materials are gradually eliminated by the market due to some defects such as non-degradable and absorbable, irritating to tissues, and easy to cause infection.
Most of the third-generation materials are currently approved by the FDA and have been widely used clinically. However, these products have more or less shortcomings such as purity and degradation speed are difficult to control.

Method used

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  • Gelatin for preventing conglutination in the surgical and the method for preparing the same
  • Gelatin for preventing conglutination in the surgical and the method for preparing the same
  • Gelatin for preventing conglutination in the surgical and the method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] An anti-adhesion gel for surgery, comprising 1 part by weight of refined modified carboxymethyl chitosan with a molecular weight of 350,000-400,000 daltons and 30 parts by weight of water for injection, and the dynamic viscosity of the anti-adhesion gel is 900 centipoise; prepared The method steps are as follows:

[0036] (1) Removal of pyrogens such as impurity proteins in chitin raw materials

[0037] Weigh 2kg of commercially available chitin with a molecular weight of about 750,000 Daltons, add 6kg of aqueous sodium hydroxide solution, the concentration of aqueous sodium hydroxide solution is 20% (w / v), stir at 70°C for 6 hours, and dissolve with pyrogen-free water. Chitin was rinsed until the pH was neutral, and dried for later use.

[0038] (2) Carboxymethylation modification of chitin

[0039] Weigh 1 kg of chitin treated in step (1), soak it with 3 kg of 45% (w / v) sodium hydroxide aqueous solution at room temperature for 3 hours, and stir fully at 100-120 rpm....

Embodiment 2

[0049] An anti-adhesion gel for surgery, comprising 1 part by weight of refined modified carboxymethyl chitosan with a molecular weight of 600,000-650,000 daltons and 20 parts by weight of water for injection, and the dynamic viscosity of the anti-adhesion gel is 2800 centipoise; The preparation method steps are as follows:

[0050] (1) Remove pyrogens such as impurity protein in raw materials

[0051] Weigh 2kg of commercially available chitin with a molecular weight of about 900,000 Daltons, add 10kg of aqueous sodium hydroxide solution, the concentration of aqueous sodium hydroxide solution is 25% (w / v), stir at 80°C for 5 hours, and dissolve the chitin with pyrogen-free water. Chitin was rinsed until the pH was neutral, and dried for later use.

[0052] (2) Carboxymethylation modification of chitin

[0053] Weigh 1 kg of the above-mentioned chitin, soak it with 4 kg of 50% (w / v) sodium hydroxide aqueous solution at room temperature for 5 hours, and fully stir at 100-120 rp...

Embodiment 3

[0063] Under aseptic conditions, take the carboxymethyl chitosan refined after drying in embodiment 2, prepare the anti-adhesion gel preparation according to the following ratio with a pyrogen-free utensil:

[0064] Refined carboxymethyl chitosan 0.1kg

[0065] Water for injection 2.5kg

[0066] Anti-adhesion gel dynamic viscosity 1600 centipoise

[0067] The above-mentioned anti-adhesion gel is fully stirred and fully swollen, and canned in disposable medical syringes under aseptic conditions, with a filling specification of 2 ml / bottle, and stored at 0°C-10°C for future use.

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Abstract

The invention discloses an anti-blocking gel used in surgery and a method for preparing the same. The anti-blocking gel comprises 1 weight% carboxymethyl chitosan having molecular weight of 300000-700000 dalton and 20-30 weight% water for injection, which dynamics viscosity is 800~3000 centipoise. The preparing method comprises: removing impurity protein pyrogen from the raw material; carboxymethyl-modification of chitin; purifying the carboxymethyl chitosan; preparing the anti-blocking gel and the preparation thereof. Accordingly, the anti-blocking gel has exellent biological barrier performance and histocompatibility, after applied on tissue wound surface, can prevent tissue tissue adhesion postoperation, which intermediary metabolite and final metabolite in human body are normal metabolites facilitating to be absorbed by the human body, without toxicity and acrimony. The anti-blocking gel has abundance material sources with low cost and simple process, thus has broad application prospects in clinical medicine art.

Description

(1) Technical field [0001] The invention relates to a surgical operation anti-adhesion gel and a preparation method thereof, belonging to the technical field of surgical medical materials. (2) Background technology [0002] Tissue adhesion after surgery has always been a major problem in clinical medicine. Tissue adhesion after surgery on the human abdomen, cardiovascular system, spine, bone joints, tendons, and gynecological pelvic cavity not only brings great pain to patients, And cause huge economic losses. In order to solve the problem of postoperative adhesion, relevant scientific and technological workers at home and abroad have been making unremitting efforts. So far, various anti-adhesion materials that have been tried can be roughly divided into three generations. The first-generation materials are non-degradable mechanical barrier materials for the human body, such as metal sheets, silk, rubber sheets, polytetrafluoroethylene, etc.; the second-generation materials...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61P41/00
Inventor 刘新利崔灵芝
Owner QILU UNIV OF TECH
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