Liquid for preventing conglutination in the surgical and the method for preparing the same

A technique for surgical operation and anti-adhesion, which is applied in the field of surgical anti-adhesion liquid and its preparation, which can solve the problems of difficult control of purity and degradation speed, non-degradable absorption, tissue irritation, etc., and achieve excellent biological barrier performance and easy absorption by the body , the effect of preventing tissue adhesion

Inactive Publication Date: 2007-09-19
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the first and second generation materials are gradually eliminated by the market due to some defects such as non-degradable and absorbable, irritating to tissues, and easy to cause infection.
Most of the third-generation materials are currently approved by the FDA and have been widely used clinically. However, these products have more or less shortcomings such as purity and degradation speed are difficult to control.

Method used

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  • Liquid for preventing conglutination in the surgical and the method for preparing the same
  • Liquid for preventing conglutination in the surgical and the method for preparing the same
  • Liquid for preventing conglutination in the surgical and the method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] An anti-adhesion liquid for surgical operations, comprising 1 weight part of refined modified carboxymethyl chitosan with a molecular weight of 200,000-250,000 Daltons and 100 parts by weight of water for injection, and the dynamic viscosity of the anti-adhesion liquid is 100 centipoise; the preparation method steps as follows:

[0037] (1) Removal of pyrogens such as impurity proteins in chitin raw materials

[0038] Weigh 2 kg of commercially available chitin with a molecular weight of about 500,000 Daltons, add 6 kg of aqueous sodium hydroxide solution, the concentration of aqueous sodium hydroxide solution is 40% (w / v), stir at room temperature for 3 hours, and decontaminate the chitin with pyrogen-free water. Rinse until the pH is neutral, and spin dry for later use.

[0039] (2) Carboxymethylation modification of chitin

[0040] Weigh 1 kg of chitin treated in step (1), soak it with 4 kg of 50% (w / v) sodium hydroxide aqueous solution at room temperature for 30 m...

Embodiment 2

[0050] An anti-adhesion liquid for surgical operations, comprising 1 part by weight of refined modified carboxymethyl chitosan with a molecular weight of 250,000-300,000 Daltons and 30 parts by weight of water for injection, and the dynamic viscosity of the anti-adhesion liquid is 800 centipoise; its preparation The method steps are as follows:

[0051] (1) Remove pyrogens such as impurity protein in raw materials

[0052] Weigh 2 kg of commercially available chitin with a molecular weight of about 700,000 Daltons, add 4 kg of aqueous sodium hydroxide solution, the concentration of aqueous sodium hydroxide solution is 55% (w / v), stir at room temperature for 5 hours, and decontaminate the chitin with pyrogen-free water. Rinse until the pH is neutral, and spin dry for later use.

[0053] (2) Carboxymethylation modification of chitin

[0054] Weigh 1 kg of the above-mentioned chitin, soak it with 5 kg of 55% (w / v) sodium hydroxide aqueous solution at room temperature for 0.5 ho...

Embodiment 3

[0064] Under aseptic conditions, take by weighing the carboxymethyl chitosan refined after drying in embodiment 2, prepare the anti-adhesion liquid preparation according to the following ratio with a pyrogen-free utensil:

[0065] Refined carboxymethyl chitosan 0.5kg

[0066] Water for injection 25kg

[0067] Anti-adhesion liquid dynamic viscosity 500 centipoise

[0068] The above anti-adhesion liquid is fully stirred and fully swollen, and canned in disposable medical syringes under aseptic conditions, with a filling specification of 2 ml / bottle, stored at 0°C-10°C for future use.

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Abstract

The invention discloses an anti-blocking liquid used in surgery and a method for preparing the same. The anti-blocking liquid comprises 1 weight% carboxymethyl chitosan having molecular weight of 200000-300000 dalton and 30-100 weight% water for injection, which dynamics viscosity is 100~800 centipoise. The preparing method comprises: removing impurity protein pyrogen from the raw material; carboxymethyl-modification of chitin; purifying the carboxymethyl chitosan; preparing the anti-blocking liquid and the preparation thereof. Accordingly, the anti-blocking liquid has excellent biological barrier performance and histocompatibility, after applied on tissue wound surface, can prevent tissue tissue adhesion postoperation, which intermediary metabolite and final metabolite in human body are normal metabolites facilitating to be absorbed by the human body, without toxicity and acrimony. The anti-blocking liquid has abundance material sources with low cost and simple process, thus has broad application prospects in clinical medicine art.

Description

(1) Technical field [0001] The invention relates to a surgical operation anti-adhesion fluid and a preparation method thereof, belonging to the technical field of surgical medical materials. (2) Background technology [0002] Tissue adhesion after surgery has always been a major problem in clinical medicine. Tissue adhesion after surgery on the human abdomen, cardiovascular system, spine, bone joints, tendons, and gynecological pelvic cavity not only brings great pain to patients, And cause huge economic losses. In order to solve the problem of postoperative adhesion, relevant scientific and technological workers at home and abroad have been making unremitting efforts. So far, various anti-adhesion materials that have been tried can be roughly divided into three generations. The first-generation materials are non-degradable mechanical barrier materials for the human body, such as metal sheets, silk, rubber sheets, polytetrafluoroethylene, etc.; the second-generation materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61P41/00
Inventor 刘新利崔灵芝
Owner QILU UNIV OF TECH
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