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Application of chlorogenic acid for preparing medicine to treat diabetes complications

An anti-diabetic and complication technology, applied in the field of chlorogenic acid, can solve unseen problems and achieve the effects of less side effects, treatment of diabetic complications, and inhibition of aldose reductase activity

Inactive Publication Date: 2009-06-24
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chlorogenic acid chlorogenic acid, CGA, also known as coffee tannic acid, is higher in honeysuckle and Eucommia, and has a wide range of pharmacological effects, such as: cardiovascular protection; antimutagenic and anticancer effects; antibacterial and antiviral effects; Lipid-lowering effect; anti-leukemia effect; immunomodulatory effect and hypoglycemic effect, there are no reports about chlorogenic acid inhibiting aldose reductase activity in domestic and foreign literatures. The present invention provides chlorogenic acid as a new aldose reductase Inhibitors, used to treat complications of diabetes

Method used

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  • Application of chlorogenic acid for preparing medicine to treat diabetes complications
  • Application of chlorogenic acid for preparing medicine to treat diabetes complications
  • Application of chlorogenic acid for preparing medicine to treat diabetes complications

Examples

Experimental program
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Effect test

Embodiment 1

[0013] Embodiment 1: The composition of chlorogenic acid is made into 1000 grains by 1-50 grams of chlorogenic acid and 450-499 grams of cellulose. The preparation method is as follows: granulating chlorogenic acid and cellulose, then compressing into tablets or filling capsules, and each grain (tablet) contains 1-50 mg of chlorogenic acid.

Embodiment 2

[0014] Embodiment 2: The composition of chlorogenic acid is prepared by adding 1-50 grams of chlorogenic acid to 1 liter of water for injection, and then packing into 1000 sticks. Its preparation method is as follows: dissolve chlorogenic acid in water for injection, add to 1 liter, sterilize, and subpackage. Each bottle contains 1-50mg chlorogenic acid.

Embodiment 3

[0015] Embodiment 3: The composition of chlorogenic acid is prepared by adding 1-50 grams of chlorogenic acid to 1 liter of water for injection, and then packing into 1000 sticks. The preparation method is as follows: dissolving chlorogenic acid in water for injection, adjusting the pH to 4.5-7.0, adding water to 1 liter, sterilizing, subpackaging, and making eye drops. Each bottle contains 1-50mg chlorogenic acid.

[0016] Study on Inhibitory Effect of Chlorogenic Acid on Aldose Reductase

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Abstract

The invention relates to the application of chlorogenic acid in the preparation of medicines for anti-diabetic complications. In the present invention, chlorogenic acid and pharmaceutical carriers and / or excipients can be used to prepare pharmaceutical compositions. The prepared medicinal composition is used for inhibiting the activity of aldose reductase, preventing and treating diabetic complications, and has the advantages of good curative effect and few side effects.

Description

technical field [0001] The present invention relates to the use of chlorogenic acid, in particular to the use in the pharmaceutical field. Background technique [0002] The long-term hyperglycemia state of diabetes will cause harm to many tissues and organs in the body, and can cause diabetic kidney, retina, nerve and other lesions. Closely related, the application of aldose reductase inhibitors can prevent and treat these complications. Many aldose reductase inhibitors have been used clinically, such as Sobinil, Epostat, Dox, etc., but their use is limited because of their severe side effects. Therefore, it is urgent to screen drugs with less toxic and side effects and strong inhibitory effect on aldose reductase from traditional Chinese medicines in my country. [0003] Chlorogenic acid chlorogenic acid, CGA, also known as coffee tannic acid, has a high content in honeysuckle and Eucommia, and has a wide range of pharmacological effects, such as: cardiovascular protectio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/216A61P3/10A61P13/12A61P25/00A61P27/02
Inventor 丁虹王莹
Owner WUHAN UNIV
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