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New application of peony blood stasis removing preparation in preparing medicaments for preventing or treating diabetic complication

A Danhong Huayu Recipe and a complication technology are applied in the field of the use of Danhong Huayu Recipe in the preparation of medicines for preventing or treating diabetes complications, and can solve the problems of lack of ideal medicines, and achieve stable and controllable quality, inhibiting Aldose reductase activity, less side effects

Active Publication Date: 2011-05-25
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no ideal drug for the treatment of diabetic complications, especially microvascular complications

Method used

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  • New application of peony blood stasis removing preparation in preparing medicaments for preventing or treating diabetic complication
  • New application of peony blood stasis removing preparation in preparing medicaments for preventing or treating diabetic complication
  • New application of peony blood stasis removing preparation in preparing medicaments for preventing or treating diabetic complication

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Effect of Example 1 on the Activity of Kidney Aldose Reductase in Diabetic Rats

[0026] 1. Materials and methods

[0027] 1.1 Medicine and its preparation The preparation method of Danhong Huayu Decoction is as follows:

[0028] 29 parts of Danshen, 11.5 parts of Angelica, 15 parts of Chuanxiong, 11.5 parts of peach kernel, 11.5 parts of safflower, 11.5 parts of Bupleurum, and 10 parts of Citrus aurantii.

[0029] The above seven medicinal materials, Bupleurum and Citrus aurantium are distilled to extract aromatic water; separated to obtain the medicinal liquid and medicinal residue, and the medicinal liquid is stored in another container; , filtered, the filtrate was concentrated under reduced pressure to a relative density of 1.15 to 1.20 (60°C), left to cool, added ethanol to make the alcohol content reach 60%, left for 12 hours, filtered, the filtrate recovered ethanol and concentrated to a relative density of 1.13 ~1.15 (60°C), add concentrated aromatic water an...

Embodiment 2

[0042] The preparation method of Danhong Huayu Formula is as follows:

[0043] 25 parts of Danshen, 8 parts of Angelica, 17 parts of Chuanxiong, 9 parts of peach kernel, 14 parts of safflower, 10 parts of Bupleurum, and 13 parts of Citrus aurantii.

[0044] The above seven medicinal materials, Bupleurum and Citrus aurantium are distilled to extract aromatic water; separated to obtain the medicinal liquid and medicinal residue, and the medicinal liquid is stored in another container; , filtered, the filtrate was concentrated under reduced pressure to a relative density of 1.15 to 1.20 (60°C), left to cool, added ethanol to make the alcohol content reach 60%, left for 12 hours, filtered, the filtrate recovered ethanol and concentrated to a relative density of 1.13 ~1.15 (60°C), add concentrated aromatic water and 5000ml water under constant stirring, mix well, adjust pH to 6.0-7.0, refrigerate, and filter. Add an appropriate amount of preservative, stir well, add water to make ...

Embodiment 3

[0046] The preparation method of Danhong Huayu Formula is as follows:

[0047] 35 parts of Danshen, 15 parts of Angelica, 8 parts of Chuanxiong, 16 parts of peach kernel, 7 parts of safflower, 15 parts of Bupleurum, and 5 parts of Citrus aurantii.

[0048] The above seven medicinal materials, Bupleurum and Citrus aurantium are distilled to extract aromatic water; separated to obtain the medicinal liquid and medicinal residue, and the medicinal liquid is stored in another container; , filtered, the filtrate was concentrated under reduced pressure to a relative density of 1.15 to 1.20 (60°C), left to cool, added ethanol to make the alcohol content reach 60%, left for 12 hours, filtered, the filtrate recovered ethanol and concentrated to a relative density of 1.13 ~1.15 (60°C), add concentrated aromatic water and 3000ml water under constant stirring, mix well, adjust pH to 6.0-7.0, refrigerate, and filter. Add an appropriate amount of preservative, stir well, add water to make u...

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Abstract

The invention discloses an application of peony blood stasis removing preparation in preparing medicaments for preventing and treating diabetic complication. The peony blood stasis removing preparation inhibits the activity of aldose reductase and the formation of a glycosylation end product, and has the new pharmacological functions of reducing the contents of bandicoot blood sugar of diabetic nephropathy (DN), glycosylated hemoglobin (GHb), blood urea nitrogen (BUN) and serum creatinine (Scr), raising the content of high-density lipoprotein of serum, reducing the content of triglyceride andcholesterol, enhancing the nitrogen oxide level of the serum and reducing the content of endothelin and the like. Based on the pharmacological functions, the peony blood stasis removing preparation can be completely used for preventing and treating the chronic diabetic complication, and has precise treating effect, fewer side effects, high safety, abundant resource, easy making process, controllable and stable quality and wide market prospect.

Description

technical field [0001] The invention relates to a new application of a Danhong Huayu prescription, in particular to a new application of a Danhong Huayu prescription in preparing medicines for preventing or treating diabetic complications. Background technique [0002] Diabetes is a metabolic disease with a complex pathogenesis and difficult to control. When it develops to a certain extent, it will be complicated by a variety of complications, also called complications. The common ones are diabetic microvascular complications, such as diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, etc. , Arteriosclerotic diseases, such as ischemic heart disease, cerebrovascular disease, arteriosclerosis obliterans, etc. At present, there is no ideal drug for the treatment of diabetic complications, especially microvascular complications. [0003] At present, it is generally recognized in the academic circles that the prevention and treatment of chronic complications of dia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P17/02A61P3/10A61P9/10A61K36/752A61P9/12A61P27/02A61P13/12
Inventor 覃仁安李楚源李淑如
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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