Application of coptis astragalus scutellaria composition in preparation of drug for preventing and treating diabetic complication

A composition and technology of astragalus polysaccharide are applied to the effective part composition of Huanglian, Astragalus and Scutellaria baicalensis, the application field in preventing and treating diabetic complications, and can solve the problems that have not been seen before.

Inactive Publication Date: 2013-06-05
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Coptis chinensis total alkaloids, astragalus polysaccharides and scutellaria baicalensis total flavonoids are the main active ingredients of Chinese medicines Coptis chinensis Franch., Astragalus membranaceus Bge. and Scutellaria baicalensis Georgi respectively. A report on the effective combination of traditional Chinese medicine used in the prevention and treatment of diabetic complications

Method used

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  • Application of coptis astragalus scutellaria composition in preparation of drug for preventing and treating diabetic complication
  • Application of coptis astragalus scutellaria composition in preparation of drug for preventing and treating diabetic complication
  • Application of coptis astragalus scutellaria composition in preparation of drug for preventing and treating diabetic complication

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1 prepares pharmaceutical composition clinical commonly used preparation

[0014] According to the weight percentage, the total alkaloids of Coptidis rhizome, polysaccharides of astragalus and total flavonoids of scutellaria baicalensis are taken, and the weight percentage of compatibility thereof is 1:1:1 or 2:2:1 or 1:2:1. The common clinical preparations of the pharmaceutical composition are prepared according to conventional methods, and the dosage forms of the pharmaceutical composition preparation include oral solid preparations such as granules, tablets and capsules.

Embodiment 2

[0016] 1. In vitro experiment: Inhibitory effect of Coptidis Astragalus and Scutellaria baicalensis composition on non-enzymatic reactions and their end products

[0017] (1) Materials

[0018] Bovine serum albumin (BSA) was purchased from Shanghai Boao Biotechnology Co., Ltd., batch number 080325; D-glucose, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium chloride, nitro blue tetrazolium chloride (NBT) , sodium azide was purchased from Sinopharm Group Chemical Reagent Co., Ltd., batch numbers were F20050712, F20080619, F20070810, F20080114, F20080408; sodium carbonate and sodium bicarbonate were purchased from Shanghai Hongguang Chemical Factory, batch numbers were 071014, 080212; metformin hydrochloride tablets Purchased from Shanghai Huashi Pharmaceutical Co., Ltd., batch number 071113; 1-deoxy-1-morpholine fructose (DMF) was purchased from Sigma Company, batch number 011H4030.

[0019] (2) Method

[0020] 1 The establishment of in vitro protein NEG syste...

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Abstract

The invention discloses a novel application of a composition of active fractions of traditional Chinese medicine in preventing and treating diabetic complications. Especially, the composition comprises the active fractions of coptis, astragalus and scutellaria with a weight ratio of 1:1:1 or 2:2:1 or 1:2:1. The invention relates to the application in the preparation of drugs for preventing and treating diabetic complications, in particular to the application in drugs for inhibiting non-enzymatic reactions and end product thereof.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a medicine for preventing and treating diabetic complications, in particular to a composition of active parts of three traditional Chinese medicines of Coptis chinensis, Astragalus and Scutellaria baicalensis and its application in preventing and treating diabetic complications. Background technique [0002] Diabetes mellitus (DM) complications are chronic diseases of multiple tissues such as eyes, kidneys, nerves, blood vessels and heart caused by the prolongation of diabetes mellitus (DM), and are the main cause of death and disability caused by diabetes. Early diabetic nephropathy, early diabetic heart disease, and diabetic retinopathy are the "triad" of diabetic microangiopathy and the most common complication of diabetes. [0003] At present, the prevention and treatment of diabetic complications is mainly carried out in the following aspects: 1. Elimination of ins...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61P3/10
Inventor 周明眉赵爱华杨红舟范自全贾伟
Owner SHANGHAI UNIV OF T C M
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