Xiegan-anshen oral-preparation preparing method and preparation thereof

The technology of gentian and scutellaria baicalensis is applied in the field of oral preparations and preparation of oral preparations for purging the liver and calming the nerves, and can solve the problems of large dosage, inconvenience to carry, poor efficacy and the like

Active Publication Date: 2009-07-29
成都倍特得诺药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But the weak point of this preparation and its drug standard is that its preparation method is relatively primitive, simple and rough, and what adopt is the method that the raw material of traditional Chinese medicine is directly pulverized and then flooded into pills, without extracting and refining active ingredients, so the dosage is large, The curative effect is poor, the action is slow, not easy to carry, and it is not suitable to adopt more advanced preparation technology in pharmacy and add pharmaceutically acceptable excipients to make it small in dosage, easy to carry, better in curative effect and faster in action A variety of modern dosage forms such as tablets, capsules, mixtures, etc., limit the scope of clinical application of this type of drug
Another shortcoming is that different extraction and refining methods are not adopted according to the properties of each raw material component, which also affects the quality of the preparation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the tablet preparation of medicine of the present invention

[0017] Take gentian 62.5g, mother-of-pearl 416.7g, scutellaria baicalensis 62.5g, gardenia (ginger roast) 62.5g, tribulus terrestris (salt roast without thorns) 62.5g, oyster 104.2g, keel 104.2g, Poria cocos 62.5g, plantago seed ( Salt roast) 62.5g, Alisma (salt roast) 62.5g, Suanzaoren (stir-fried) 104.2g, Baiziren 62.5g, Polygala (removed licorice) 62.5g, Rehmannia glutinosa 62.5g, Ophiopogon japonicus 62.5g, Angelica 62.5g , licorice 20.8g, of which Poria cocos and Alisma are decocted with 8 times the amount of water (soaked for 8 hours for the first time), each time for 1.5 hours, and the decoctions are combined and concentrated to a relative density of 1.20 (80°C); mother of pearl, Add 5 times the amount of water to decoct oysters and keel for 3 times, each time for 3 hours, and concentrate the decoction to the amount of feeding (g): liquid volume (ml) = 10:1; gentian, scutellaria, gardenia...

Embodiment 2

[0018] Embodiment 2: the capsule preparation of medicine of the present invention

[0019] Take 83.3g of gentian, 555.6g of mother of pearl, 83.3g of scutellaria baicalensis, 83.3g of gardenia (ginger roast), 83.3g of terrestris (removing thorn and salt roast), 138.9g of oyster, 138.9g of keel, 83.3g of poria cocos, plantago seed ( Salt roast) 83.3g, Alisma (salt roast) 83.3g, Suanzaoren (stir-fried) 138.9g, Baiziren 83.3g, Polygala (removed licorice) 83.3g, Rehmannia glutinosa 83.3g, Ophiopogon japonicus 83.3g, Angelica 83.3g , licorice 27.8g, of which Poria cocos and Alisma are crushed into the finest powder, passed through a 100-mesh sieve; mother-of-pearl, oysters, and keel are decocted with 7 times the amount of water for 3 times, each time for 3 hours, and the decoctions are combined and then concentrated to feed Quantity (g): liquid volume (ml) = 8:1; add 8 times the amount of gentian, scutellaria baicalensis, gardenia, cypress kernel, jujube kernel, polygala, angelica,...

Embodiment 3

[0020] Embodiment 3: the mixture preparation of medicine of the present invention

[0021] Take gentian 25g, mother-of-pearl 166.7g, scutellaria baicalensis 25g, gardenia (ginger roast) 25g, tribulus terrestris (salt roast) 25g, oyster 41.7g, keel 41.7g, Poria cocos 25g, plantain seed (salt roast) 25g, Alisma (salted) 25g, Suanzaoren (stir-fried) 41.7g, Baiziren 25g, Polygala (removed licorice) 25g, Rehmannia glutinosa 25g, Ophiopogon japonicus 25g, Angelica 25g, Licorice 8.3g, of which Poria and Alisma are the first Add 8 times the amount of water to soak for 10 hours and then decoct, add 6 times the amount of water to decoct for the second and third times, each time for 1 hour, the decoction liquid is combined and concentrated to a relative density of about 1.10 (60°C); gentian, Add 8, 6, and 6 times the amount of water to decoct Scutellaria baicalensis, gardenia, cypress kernels, jujube kernels, polygala, angelica, rehmannia glutinosa, Ophiopogon japonicus, Tribulus terrest...

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Abstract

The invention discloses a method for preparing xiegan anshen oral preparation and the oral preparation, and its characters lie in dividing raw materials into three groups, respectively crushing or extractive refining according to process conditions of research, combining the made intermediate products, and adding in pharmaceutically acceptable auxiliary materials or not to make different preparation treatments so as to make different oral solid or liquid preparations. It can be made into xiegan anshen pills with small dosage and good curative effect and is suitable to be made into multiple oral solid and liquid preparations such as tablets, capsules, mixtures, etc., reducing dosage, improving curative effect and providing more forms of prepared drugs for clinic patients to select.

Description

technical field [0001] The invention relates to a method for preparing a Chinese patent medicine and a preparation made by the method, in particular to a method for preparing an oral preparation for purging the liver and calming the nerves and the oral preparation made by the method. Background technique [0002] Xiegan Anshen Pill is a kind of Chinese patent medicine widely used clinically. It consists of 9 parts of gentian, 9 parts of scutellaria, 9 parts of gardenia (steamed ginger), 60 parts of mother-of-pearl, 15 parts of oyster, 15 parts of keel, and 9 parts of Baiziren. 15 parts of Suanzaoren (stir-fried), 9 parts of Polygala (burned with licorice removed), 9 parts of Angelica, 9 parts of Rehmannia glutinosa, 9 parts of Ophiopogon japonicus, 9 parts of Tribulus terrestris (salted with thorns removed), 9 parts of Poria cocos, psyllium seed (salt roast) 9 parts, Alisma (salt roast) 9 parts, 3 parts of licorice were ground into fine powder, sieved, mixed evenly, made int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61K35/56A61K35/02A61K9/00A61K9/10A61K9/06A61K9/14A61K9/16A61K9/20A61K9/48A61P25/20A61K35/618
Inventor 张沛冯华祥张林
Owner 成都倍特得诺药业有限公司
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