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Composition containing erigeron breviscapus for treating cardiovascular diseases and its preparation

A composition, the technology of breviscapus, is applied in the direction of cardiovascular system diseases, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as difficult preparation of dripping pills

Active Publication Date: 2007-12-12
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strict requirements of the drop pill preparation process on the matrix excipients, it is often difficult to prepare drop pills that meet the quality requirements after replacing the matrix excipients. Therefore, finding a suitable matrix excipient to replace the current polyethylene glycol has become a constant effort of medical personnel. direction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The raw materials are 97g of Salvia miltiorrhiza, 79g of notoginseng, 35g of breviscapita, 3g of balsamic oil, and 40g of ginseng

[0067] Salvia miltiorrhiza, panax notoginseng, breviscapita and ginseng were decocted with 5 times the amount of water for 2 hours, filtered, and the residue was extracted for the second time, added with 4 times the amount of water, decocted for 1 hour, filtered, the residue was discarded, and the filtrate was combined. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. Add balsamic oil, dry, make granules, compress into tablets, or coat with sugar, that is to say.

Embodiment 2

[0069] Danshen 100g, Sanqi 10g, Erigeron 15g;

[0070] Salvia miltiorrhiza, notoginseng, and breviscapus are extracted with 70% ethanol, and the extract is microfiltered with a ceramic membrane to collect the filtrate; the filtrate is ultrafiltered, and the operating conditions of the ultrafiltration process are: The liquid outlet pressure is 0.20kPa lower than the liquid inlet pressure. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m / s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m / s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to v...

Embodiment 3

[0073] The raw materials are 20g of salvia miltiorrhiza, 2g of notoginseng, 10g of breviscapine, 100g of angelica, and 2.2g of borneol.

[0074] Add 5 times the amount of water to Danshen, Panax notoginseng, Breviscapus and Angelica, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and combine the filtrate. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. The extract and borneol are fluidized with lactose in a batch fluidized bed, dried, and made into granules.

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared from root of red rooted saliva, notoginseng, Breviscapine, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing breviscapita for treating cardiovascular diseases and a preparation thereof, in particular to a pharmaceutical composition for treating cardiovascular diseases which is made from traditional Chinese medicinal materials. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth respectively among the causes of death in my country, and rose to second and third respectively after 1970. Cardiovascular and cerebrovascular diseases accounted for the first of all causes of death. In my country, the proportion of deaths due to cardiovascular and cerebrovascular diseases to the total death population has risen from 12.07% in 1957...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61K47/36A61P9/10A61K35/55A61K31/122A61K31/045
Inventor 李旭郑永锋李永强
Owner TIANJIN TASLY PHARMA CO LTD
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