Method for normal-temperature high-pressure aconine extracting and formulated product thereof

A technology of aconitine and aconitine, which is applied in the field of medicine, can solve problems affecting human health, difficulty in realizing industrial scale, and high noise, and achieve the effects of shortening working hours, reducing component losses, and saving energy

Active Publication Date: 2008-01-23
XIUZHENG PHARMA GRP CHANGCHUN HIGH NEW PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ultrasonic and microwave extraction shorten the extraction time and reduce energy consumption, the main problem is that it is not easy to achieve industrial scale, and the noise is large, which affects human health

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Crush Aconitum aconitum and Aconitum aconitifolia into coarse powder, add ethanol at a ratio of 1g: 6ml of medicinal material to solvent, mix and seal, then soak at room temperature for 3 hours, put the mixture into a high-pressure container, and apply a pressure of 200MPa at room temperature for extraction. Keep the pressure for 3 minutes, filter after releasing the pressure, add water to the medicinal residue at a ratio of 1g:6ml of medicinal materials and solvent, mix and seal it, put it in a high-pressure container, apply a pressure of 200MPa at room temperature for extraction, keep the pressure for 3 minutes, and release the pressure Filtration; combine the two extracts, concentrate until there is no alcohol smell, adjust the pH value to 3-6.5, filter, concentrate, add ethanol to make the alcohol content reach 40%, let stand overnight, filter, and concentrate the filtrate to no alcohol Taste, filter, add water for injection to the specified amount, fill, and sterili...

Embodiment 2

[0055] Crush Aconitum aconitum and Aconitum aconitifolia into coarse powder, add ethanol at a ratio of 1g: 10ml of medicinal material to solvent, mix and seal, soak at room temperature for 5 hours, put the mixture into a high-pressure container, and apply a pressure of 400MPa at room temperature for extraction. Keep the pressure for 5 minutes, filter after releasing the pressure, add water to the medicinal residue at a ratio of 1g:10ml of medicinal materials and solvent, mix and seal it, put it in a high-pressure container, apply a pressure of 400MPa at room temperature for extraction, keep the pressure for 5 minutes, and release the pressure Filtration; combine the two extracts, concentrate until there is no alcohol smell, adjust the pH value to 3-6.5, filter, concentrate, add ethanol to make the alcohol content reach 50%, let stand overnight, filter, and concentrate the filtrate to no alcohol Taste, filter, add water for injection to the specified amount, fill, and sterilize ...

Embodiment 3

[0057] Crush Aconitum aconitum and Aconitum aconitifolia into coarse powder, add ethanol at a ratio of 1g: 15ml of medicinal materials to solvent, mix and seal, soak at room temperature for 8 hours, put the mixture into a high-pressure container, and apply a pressure of 600MPa at room temperature for extraction. Hold the pressure for 8 minutes, filter after releasing the pressure, add water to the medicinal residue at a ratio of 1g:15ml of medicinal materials and solvent, mix and seal it, put it in a high-pressure container, apply a pressure of 600MPa at room temperature for extraction, hold the pressure for 8 minutes, and release the pressure Filtration; combine the two extracts, concentrate until there is no alcohol smell, adjust the pH value to 3-6.5, filter, concentrate, add ethanol to make the alcohol content reach 75%, let stand overnight, filter, and concentrate the filtrate to no alcohol Taste, filter, add water for injection to the specified amount, fill, and sterilize...

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PUM

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Abstract

A method for extracting the aconitine under normal temperature and superhigh pressure and the produced preparation are provided, which belongs to the medical technology field. The method is that the traditional Chinese medicinal materials in the aconitine are crushed to coarse powder and are added with the ethanol and soaked under normal temperature after mixing and closing; the mixture is put in a high pressure vessel and extracted by exerting pressure of 100MPa to 1000MPa under normal temperature and filtered after pressure maintaining and pressure relief; the dregs of a decoction are added with water based on the ratio of 1g : 1ml to 30ml between the medicine and solvent and are put in the high pressure vessel after mixing and closing and extracted by exerting pressure under normal temperature and filtered after pressure maintaining and pressure relief; the extracting solution twice is combined and condensed until the alcohol smell does not exist, and filtered after adjusting the pH value and condensed, and added with ethanol to make the alcohol content of 50 per cent to 80 per cent, and put still through night and filtered; the filter liquor is condensed, filtered and added with water for injection to the specified amount, bulked, sterilized to gain the aconitine. The invention has the positive effects of high extraction ratio, short extraction time, low solvent consumption and green environment protection.

Description

Technical field: [0001] The medical technology of the present invention particularly relates to a method for extracting aconitine (monoester alkaloid) by ultra-high pressure technology at normal temperature and the preparation thereof, A61P35 / 00. technical background: [0002] The traditional Chinese medicine Aconitum is the root tuber of the perennial herbaceous plant Aconitum of the Ranunculaceae, including Chuanwu and Caowu. Clinically, its main efficacy is to dispel wind and dampness, dissipate cold and relieve pain. It is often used to treat diseases such as wind-cold-damp arthralgia, joint pain, and pain from bruises. Its analgesic effect is particularly prominent. The main functions of Aconitum injection made from Aconitum aconitum and Aconitum aconitum are sedation and pain relief, and it is used for the pain of advanced cancers such as gastric cancer and liver cancer. However, due to the high toxicity of aconitum, a little carelessness in use can cause poisoning a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D221/22A61K31/435A61K9/20A61K9/48A61K9/08A61K9/06A61K36/714A61P35/00
Inventor 高陆王丽清张守勤崔彦丹刘春梅朱丽佳王长征吴华
Owner XIUZHENG PHARMA GRP CHANGCHUN HIGH NEW PHARMA CO LTD
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