Method for on-line taking off bottles from vacuum chamber of vacuum refrigerating drier
A vacuum freeze-drying and vacuum chamber technology, applied in the direction of drying solid materials, drying solid materials without heating, drying, etc., can solve problems such as inability to conduct sampling inspections in the process
Active Publication Date: 2011-04-27
SHANGHAI TOFFLON SCI & TECH CO LTD
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Problems solved by technology
However, in each stage of the processed product, the condition of the liquid medicine, such as the crystallization thickness of the liquid medicine during freezing, the shape of the product during the primary drying and secondary drying processes, the measurement of moisture content, and the analysis of components, etc. cannot be sampled and inspected in the process, and can only be checked by the final drying process. After the end, the dried sample taken out is tested;
[0005] 2. The control of the freeze-drying process is based on experience, and it may take more than one test to obtain a basically feasible freeze-drying curve;
[0006] 3. When the freeze-drying curve of the same product is obtained from the experiment, or other varieties have never been applied to this machine, it may not be possible to directly apply the existing freeze-drying curve to the mass-production vacuum freeze dryer. Multiple data adjustments need to be made on the freeze dryer, and the inspection of the same batch of finished products still requires a sampling inspection after the freeze-drying to confirm the integrity of the finished product
Method used
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[0025] As shown in Figure 1, it is a schematic diagram of the structure of the manipulator. The manipulator 24 is composed of a manipulator assembly 1, a bellows assembly 2, and a movable assembly 3. The movable assembly 3 is installed in the bellows assembly 2 and is concentric with the bellows assembly 2. Shaft, the manipulator assembly 1 passes through the soft bellows on the bellows assembly 2 and the ball on the movable assembly 3 at the same time, the manipulator assembly 1 can move back and forth in the inner hole of the bellows assembly 2, and at the same time the manipulator assembly 1 passes through the soft bellows on the bellows assembly 2 The bellows and the sphere on the movable component 3 move within a certain range of conical angles to adjust the pair of clips on the manipulator component 1 to align with the indicated small bottle neck.
[0026] As shown in Figure 2, it is a schematic diagram of the structure of the manipulator assembly. The manipulator assembl...
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The invention relates to a method of online taking out a small bottle in a vacuum chamber of a vacuum freeze drying plant. The method is characterized in that a manipulator is used to online take out the small bottle at any time from the vacuum chamber of the vacuum freeze drying plant through a small vacuum chamber. The invention can grasp a medicine bottle on a shelf in the vacuum chamber of the vacuum freeze drying plant at any time through the small vacuum chamber which is arranged at one side of the vacuum freeze drying plant and provided with the manipulator component which can extend into the vacuum chamber of the vacuum freeze drying plant, as a door of the vacuum chamber of the vacuum freeze drying plant is not opened, the medicine bottle is taken out onto the small vacuum chamber from the vacuum chamber of the vacuum freeze drying plant by the manipulator and pressed with a cap, and then taken out from a valve at the bottom of the small vacuum chamber, thereby achieving an aim of online taking out the small bottle from the vacuum chamber at any time but without affecting a freeze and drying process.
Description
technical field [0001] The invention relates to a method for taking out vials online in a vacuum chamber of a vacuum freeze dryer, in particular to a method for taking out and inspecting vials of medicinal liquid on-line within any time applied on a vacuum freeze dryer without affecting the freeze-drying process, which belongs to vacuum technology field. Background technique [0002] The vacuum freeze dryer is to pre-freeze the lyophilizable aqueous substance or solution at a low temperature, and then dehydrate the substance in a vacuum environment to obtain a dry product. [0003] There is following defect in existing vacuum freeze dryer at present: [0004] 1. Quantitatively pour liquid medicine products into all vials of a batch, and then place all vials through the drawer tray on the shelf in the vacuum chamber of the vacuum freeze dryer for freezing, primary drying, and secondary drying. However, in each stage of the processed product, the condition of the liquid medi...
Claims
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IPC IPC(8): F26B5/06
Inventor 郑效东
Owner SHANGHAI TOFFLON SCI & TECH CO LTD