Short-peptide triggering male penis erection and improving female libido

Abstract

The invention provides a short peptide which can trigger the male penile tumescence and improve female sexuality; the short peptide comprises a functional unit and a carrier unit; the amino acid component and constitutional formula of the functional unit is Nle-c (Asp-His-DPhe-Arg-Trp-Lys)-OH; the carrier unit is composed of 3 to 11 peptide; the functional unit is connected with the carrier unit by a peptide linkage. The functional unit with 10 peptide carrier can likely penetrate various mucous membrane, such as oral mucosa, gastric mucosa and nasal mucous membrane; the functional unit with 3 peptides can likely penetrate the skin. The animal experiments confirmed that the short peptide of the invention can trigger the male penile tumescence and improve female sexuality and can be used in treating the male erectile dysfunction and female low sexuality.

Description

technical field [0001] The invention relates to biomedical technology, in particular to the medical application of peptides, especially the application in the treatment of male erectile dysfunction and female low libido. Background technique [0002] Sexual dysfunction is a multifactorial disorder that statistically affects approximately 43% of women and 31% of men. Due to various diseases and psychological reasons, decreased libido occurs in 30% of women and 15% of men. About 10% of men suffer from erectile dysfunction, and about 20% of women suffer from low libido. Sexual dysfunction is not only widespread, but also has a great impact on quality of life and interpersonal relationships. [0003] Penile erection is a complex vascular and tissue response to psychological and neurological stimuli. The whole erection process first depends on intact erectile tissue and penile blood flow, especially the vascular endothelium-dependent vasodilation and penile corpus cavernosum-d...

AI Technical Summary

Problems solved by technology

However, about 50% of patients treated with cedemol eventually discontinue the drug. Among many reasons, its side effects such as headache, rash, and visual changes are very important reasons, and its potential hypotension is also an important reason.

[0004] For the treatment of erectile dysfunction, you can also start from the central nervous system, but no ideal drug has been found

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