Antiviral partial film forming gel composition

Abstract

The invention discloses an antivirus local film-forming gel compound and the application of the gel compound, comprising the following weight-percentage components: 0.5 to 7 percent of hydroxyalkyl fibrin, 1 to 10 percent of esterifying agent, 0.5 to 5 percent of crosslinking agent, 0 to 5 percent of intensifier, 75 to 90 percent of menstruum and 0.1 to 5 percent of antivirus medicines; wherein, the crosslinking agent is a saturated fat polyol or alkyd which has the chemical general equation is CnH2n+2-m-l (OH) m (COOH) l, and n, m and l are whole numbers and n is more than or equal to m whichis more than or equal to 2, and l is more than or equal to 0, and m plus 1 is from 4 to 8 and n plus 1 is from 4 to 8. When the antivirus local film-forming gel compound of the invention is spread onto skin or a mucosa surface, a smooth, tough, wear-resistant and waterproof protection film can be formed. Compared with the existing various antivirus local agents, the film formed by the gel compound is characterized in that the preservation time is long and the medicine effect can be released for a long time. The formed gel film can be preserved for more than 7 hours on the skin surface and can be preserved for about 5 hours on the surface of the oral mucosa, with better anti local virus-infection of both skin and mucosa.

Description

technical field [0001] The invention relates to an antiviral local film-forming gel composition for treating skin and mucous membrane local viral infectious diseases. Background technique [0002] Local viral infections of the skin and mucous membranes are usually caused by human papillomavirus, herpes virus, etc., such as flat warts, common warts, plantar warts, condyloma acuminata, herpes zoster and herpetic stomatitis. Aciclovir, Penciclovir and Ganciclovir are deoxyguanosine broad-spectrum antiviral drugs, which are widely used in clinical treatment of various viral infectious diseases , its commonly used external dosage forms include ointment, cream, gel, etc., when this type of preparation is applied to the surface of skin tissue, due to the friction with clothes or the outside world, the secretion of body fluids and the infiltration of sweat, these agents are easy to absorb. It is wiped off or washed off, and usually lasts for a short time on the skin surface, result...

AI Technical Summary

Problems solved by technology

However, we found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, but the time to adhere to the skin or mucous membrane is relatively short, such as in the oral cavity. The film formed on the mucous membrane is easily eroded / dissolved by body fluids or saliva, causing the film to rupture and fall off prematurely, resulting in faster disappearance

[0007] Therefore, as adopting the technology of above-mentioned existing film-forming gel composition to prepare antiviral local film-forming gel composition, then the medicament wherein and affected part keep time is shorter, influences curative effect

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