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Application of sanchi flower total saponine in preparing treatment hypertension disease medicament
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A technology of hypertension and total saponins, applied in the field of application in the preparation of pharmaceutical compositions
Inactive Publication Date: 2012-03-21
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE +1
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There is no report on the treatment of hypertension
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Embodiment 1
[0012] Example 1 Extraction and Preparation of Panax notoginseng Saponins
[0013] Alcohol extraction, centrifugation, macroporous resin, concentration, drying and pulverization methods are used to obtain an extract of effective active ingredients of Panax notoginseng flower buds with stable transfer rate and yield and high purity. After color development by vanillin-glacial acetic acid method, ultraviolet spectrophotometry (UV) is detected at 548nm, and the percentage by weight of the total saponins of Panax notoginseng flower buds in the extract accounts for 50%-100% of the total weight of the extract.
Embodiment 2
[0014] Example 2: Antihypertensive effect experiment of Panax notoginseng saponins on spontaneously hypertensive rats
[0015] 1. Select 18-week-old SHR rats and WKY rats (purchased from Shanghai Institute of Hypertension)
[0016] 2. Experimental grouping:
[0017] Normal WKY group (0.9% NS duodenal administration);
[0018] SHR rats were divided into blank group (0.9% NS duodenal administration);
[0019] Panax notoginseng total saponins low-dose group (0.8g / kg of Panax notoginseng total saponins administered in the duodenum);
[0020] Middle dose group of total saponins of Panax notoginseng flower buds (1.6g / kg total saponins of Panax notoginseng flower buds administered in duodenum);
[0021] Panax notoginseng total saponins high-dose group (3.2 g / kg total saponins from Panax notoginseng flower buds administered in the duodenum);
[0022] Nifedin group (nifedin 5mg / kg duodenal administration).
[0023] 3. Acute antihypertensive test:
[0024] Each group was anestheti...
Embodiment 3
[0029] Example 3: Effect test of Panax notoginseng saponins on the proliferation of vascular smooth muscle cells
[0030] Human primary aortic smooth muscle cell line (HASMC) was selected, and HASMC was pretreated with ET-1 concentration of 2*10-8mmol / L, which caused the abnormal proliferation of HASMC. 200, 250, 300, 350, 400, 450, 500, 550, 600 μg / ml) and the control drug nifedipine (50 μg / ml). The results show that Panax notoginseng saponins can improve the cell viability of ET-1-induced vascular smooth muscle cell proliferation (see figure 1 , figure 2) .
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Abstract
The invention belongs to the field of Chinese medicine pharmacy, which relates to the application of pseudo-ginseng flower total saponin of active energy for preparing the drug for the treatment of hypertension, and the pseudo-ginseng flower total saponin is extracted from Chinese herbal medicine pseudo-ginseng flower. The in-vitro and in-vivo animal experimental results for the active energy of the invention show that the active energy can significantly lower blood pressure of spontaneously hypertensive rats (SHR), and improve the cell activity of vascular smooth muscle cell proliferation which is induced by ET-1, as well as increase the apoptosis rate of the vascular smooth muscle cell and the NO content inside the vascular smooth muscle cell; simultaneously the active energy can promote the expression of iNOS, and reduce Ca2 + concentration inside the vascular smooth muscle cell, as well as inhibite the oncogene c-mycmRNA expression of the vascular smooth muscle cell; thereby the pseudo-ginseng flower total saponin can be taken as raw material for preparing pharmaceutical preparation for the prevention of hypertension.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the application of total saponins of Panax notoginseng, the active part extracted from the Chinese herbal medicine Panax notoginseng, in the preparation of pharmaceutical compositions. Background technique [0002] Hypertension is one of the common cardiovascular diseases. According to statistics, the current incidence rate in my country is 13.58%. It is closely related to coronary atherosclerotic heart disease and cerebrovascular diseases. Although modern medicine has made great progress, But it is still one of the leading causes of death from cardiovascular disease. In recent years, with the progress of large-scale antihypertensive clinical trials and basic research on cardiovascular molecular biology, people have gradually realized that hypertension is not only a disease of hemodynamic abnormalities, but also the accumulation of various cardiovascular risk fac...
Claims
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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K36/258A61P9/12
Inventor 周端魏莉胡林森苑素云杜奕刘岭周浩
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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