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Medicine composition containing morinda root oligosacchride and its preparation method

The technology of Morinda officinalis oligosaccharide and composition is applied in the field of pharmaceutical composition containing Morinda officinalis oligosaccharide and its preparation field, and can solve the problems of increasing the feasibility of production, reducing the activity, shortening the shelf life of the product and the like.

Active Publication Date: 2011-02-16
BEIJING TONGRENTANG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Another disadvantage of fluidized bed granulation is that the heating temperature is high and the heating time is long, which will cause the bonding and denaturation of Morinda officinalis oligosaccharides, and the hygroscopicity will increase after the preparation is formed. The production environment must strictly control the humidity, which increases the feasibility of production. Difficulty in resistance, the product shelf life is shortened, and the active part will be reduced after severe heating

Method used

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  • Medicine composition containing morinda root oligosacchride and its preparation method
  • Medicine composition containing morinda root oligosacchride and its preparation method
  • Medicine composition containing morinda root oligosacchride and its preparation method

Examples

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Effect test

Embodiment 1

[0092] Embodiment 1. Preparation technology of Morinda officinalis oligosaccharide

[0093] Morinda officinalis herbal medicine 2500g, add 8 times the amount of water to decoct 4 times, 1.5 hours each time. The decoction was filtered, evaporated to dryness under reduced pressure, adsorbed on an activated carbon column, and first washed with distilled water until the eluate was negative for reducing sugar detection (sulfuric acid-phenol reaction). Then eluted with 30% ethanol. The ethanol eluted fraction was collected, concentrated under reduced pressure to a relative density of d=1.15-1.20 (50° C.), and spray-dried to obtain the Morinda officinalis oligosaccharide product.

[0094] Inspection: In the present invention, the content of 3-9 sugars in Morinda officinalis oligosaccharides is not less than 50.0%, and the content of 5 sugars is not less than 6.0% as a measure of whether the Morinda officinalis oligosaccharides used in the present invention are qualified index of. ...

Embodiment 2

[0097] Example 2. Capsules containing Morinda officinalis oligosaccharides

[0098] Prescription: Morinda officinalis oligosaccharides 150.0g, microcrystalline cellulose 150.0g.

[0099] Preparation method: Take Morinda officinalis oligosaccharides, add 150.0 g of microcrystalline cellulose, mix well, dry granulate, pack into capsules, and make 1000 capsules, and the product is ready.

[0100] Properties: This product is a capsule, the content is off-white to light yellow granules, sweet in taste.

[0101] Specifications: Each capsule contains 150mg of Morinda officinalis oligosaccharides.

Embodiment 3

[0102] Embodiment 3. Contain the granule of Morinda officinalis oligosaccharide

[0103] Prescription: Morinda officinalis oligosaccharides 150.0g, microcrystalline cellulose 150.0g.

[0104] Preparation method: take Morinda officinalis oligosaccharides, add 150.0 g of microcrystalline cellulose, mix well, and dry granulate to obtain the product.

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Abstract

The invention provides a medicinal combination containing morinda root oligosaccharide and a method for preparing the medicinal combination. The medicinal combination contains morinda root oligosaccharide and pharmaceutical excipients. The pharmaceutical excipients comprise any or the combination of microcrystalline cellulose, starch, and micropowder silica gel. The method is to prepare the combined preparation containing morinda root oligosaccharide and / or pharmaceutical excipients by adopting the dry process pellatizing method. The product provided by the invention reduces the dosage of thepharmaceutical excipients, thus reducing the dosage of sufferers and significantly improving the clinical compliance of objective sufferers.

Description

technical field [0001] The invention provides a composition containing active ingredients of traditional Chinese medicines and a preparation method, especially a composition containing Morinda officinalis oligosaccharides. Background technique [0002] Morinda officinalis How is the dried root of Rubiaceae plant Morinda officinalis How. There have been many records on the antidepressant pharmacological effects of Morinda officinalis oligosaccharides, the active ingredient in Morinda officinalis extract. In order to facilitate taking, the producer first thought of making it into a portable solid preparation containing Morinda officinalis oligosaccharides, such as capsules. [0003] Morinda officinalis oligosaccharide capsules are made from Morinda officinalis oligosaccharides added with appropriate amount of auxiliary materials to make granules and then packed into capsules. The Morinda officinalis oligosaccharide capsules given in ZL200410056935.8 adopt fluidized bed or we...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P25/24A61K36/746A61K31/715A61K47/38A61K31/702A61K9/16A61K125/00A61K9/48A61K9/14A61K9/00A61K9/20
CPCA61K31/702A61P25/24
Inventor 李志猛张绍来顾海鸥刘柏刚李银邱落杜菁张学著秦晨薛海晨吴炜张萍菊
Owner BEIJING TONGRENTANG CO LTD
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