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0Long-acting enrofloxacin injection and preparation method thereof

A technology of enrofloxacin and injection, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve multiple side effects, decreased disease resistance of livestock and poultry, and difficulty in exerting Effect and other issues, to achieve the effect of reducing the number of administration, prolonging the half-life and avoiding side effects

Inactive Publication Date: 2009-02-11
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As we all know, the treatment of livestock and poultry diseases generally requires medication 2 to 3 times a day for 3 to 5 days. Many stress diseases occur, which in turn leads to the decline of disease resistance of livestock and poultry, resulting in the occurrence and spread of many livestock and poultry diseases, etc.
Moreover, taking multiple medications every day will cause the drug concentration in the blood (referred to as blood drug concentration) to fluctuate greatly, resulting in a "peak-to-valley" phenomenon. When the drug concentration is at its peak, it exceeds the optimum therapeutic concentration, causing more side effects , or even poisoning; on the contrary, when the drug concentration drops to the bottom, it is far below the required concentration, and it is difficult to play a role

Method used

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  • 0Long-acting enrofloxacin injection and preparation method thereof
  • 0Long-acting enrofloxacin injection and preparation method thereof
  • 0Long-acting enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1: 50 parts of enrofloxacin, 10 parts of benzyl alcohol, 20 parts of polyvinylpyrrolidone, 300 parts of sodium hydroxide solution with a concentration of 20% by mass, 5 parts of ethanolamine, 0.5 part of thiourea and 614.5 parts of water for injection.

[0064] Preparation method: mix benzyl alcohol and 250 parts of water for injection, add thiourea and polyvinylpyrrolidone, heat at 75°C for 12 minutes, add enrofloxacin, stir well, add sodium hydroxide solution to make enrofloxacin Dissolve, continue to heat at 95°C for 35 minutes, add 250 parts of water for injection, add ethanolamine to adjust the pH to 7, add 114.5 parts of water for injection to 1000 parts, filter, pot, and sterilize to obtain the finished product.

[0065] The above parts are parts by weight.

Embodiment 2

[0066] Example 2: 80 parts of enrofloxacin, 40 parts of benzyl alcohol, 40 parts of polyvinylpyrrolidone, 350 parts of sodium hydroxide solution with a concentration of 15% by mass, 15 parts of ethanolamine, 0.8 part of thiourea and 474.2 parts of water for injection.

[0067] Preparation method, mix benzyl alcohol and 200 parts of water for injection, add thiourea and polyvinylpyrrolidone, heat at 80°C for 10 minutes, add enrofloxacin, stir well, add sodium hydroxide solution to make enrofloxacin Dissolve, continue to heat at 97°C for 30 minutes, add 150 parts of water for injection, add ethanolamine to adjust the pH to 8, add 122.2 parts of water for injection to 1000 parts, filter, pot, and sterilize to obtain the finished product.

[0068] The above parts are parts by weight.

Embodiment 3

[0069] Example 3: 130 parts of enrofloxacin, 60 parts of benzyl alcohol, 50 parts of polyvinylpyrrolidone, 450 parts of sodium hydroxide solution with a concentration of 10% by mass, 20 parts of ethanolamine, 1 part of thiourea and 289 parts of water for injection.

[0070] Preparation method: mix benzyl alcohol and 100 parts of water for injection, then add thiourea and polyvinylpyrrolidone, heat at 85°C for 7 minutes, add enrofloxacin, stir well, add sodium hydroxide solution to make enrofloxacin Dissolve, continue to heat at 100°C for 25 minutes, add 100 parts of water for injection, add ethanolamine to adjust the pH to 9, add 89 parts of water for injection to 1000 parts, filter, pot, and sterilize to obtain the finished product.

[0071] The above parts are parts by weight.

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Abstract

The invention provides a long-acting Enrofloxacin Injection, which is formulated by the following raw materials by weight percentage: 5-13 percent of Enrofloxacin, 1-6 percent of phenylcarbinol, 2-5 percent of polyvinylpyrrolidone, 30-45 percent of sodium hydroxide solution, 0.5-2 percent of neovaricaine, 0.05-0.1 percent of thiourea and the rest of injection water, the concentration of the sodium hydroxide solution is 10-20 percent by mass percent; the long-acting Enrofloxacin Injection is added with polyvinylpyrrolidone as slow release material, and the slow release material is evenly dispersed in treatment drugs, thus leading the drugs to be slowly released after entering an animal organism, prolonging the half-life of the drugs, maintaining effective blood concentration for a long period, reducing or avoiding the side effects caused by the fluctuation of 'peak valley' of blood concentration and achieving the purpose of being high-efficiency, long-acting and stable.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, relates to a long-acting enrofloxacin injection, and also relates to a preparation method of the injection. Background technique [0002] In recent years, my country's breeding industry has shown a rapid development trend, especially in some economically developed areas and pastoral areas, more and more livestock and poultry varieties have been introduced, and disease problems have followed one after another, and farms in various regions have continued to break out For livestock and poultry diseases, due to the uneven technical strength of various farms and limited diagnostic testing equipment, many clinical veterinarians are confused about medication, and abuse and non-targeted medication problems have become a common phenomenon. This further promotes the continuous emergence of bacterial drug resistance, making the prevention and treatment of livestock and poultry diseases mo...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/496A61K47/34A61P31/04A61K47/32
Inventor 张遂平李明魁徐泽君吴胜耀赵全成周永亮郭芳茹郭菊闫树森邵艳华王菊平张海涛
Owner 河南亚卫动物药业有限公司
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