35 results about "Enrofloxacin Injectable Solution" patented technology

The invention provides a long-acting Enrofloxacin Injection, which is formulated by the following raw materials by weight percentage: 5-13 percent of Enrofloxacin, 1-6 percent of phenylcarbinol, 2-5 percent of polyvinylpyrrolidone, 30-45 percent of sodium hydroxide solution, 0.5-2 percent of neovaricaine, 0.05-0.1 percent of thiourea and the rest of injection water, the concentration of the sodium hydroxide solution is 10-20 percent by mass percent; the long-acting Enrofloxacin Injection is added with polyvinylpyrrolidone as slow release material, and the slow release material is evenly dispersed in treatment drugs, thus leading the drugs to be slowly released after entering an animal organism, prolonging the half-life of the drugs, maintaining effective blood concentration for a long period, reducing or avoiding the side effects caused by the fluctuation of 'peak valley' of blood concentration and achieving the purpose of being high-efficiency, long-acting and stable.

The invention relates to the field of veterinary medicament, in particular to a veterinary synergic enrofloxacin injection. Based on the total amount of 100ml, the injection comprises the following components by weight: 5 to 10g of enrofloxacin, 10 to 12g of sodium salicylate, water extract of 20 to 40g of isatis root, 1 to 2g of trimethoprim, 20 to 40g of polyethylene glycol 400, 0.1 to 1g of sodium hydroxide, and the balance injection water, wherein the mass ratio of the enrofloxacin to the trimethoprim is 5 to 1; and the mass ratio of the trimethoprim to the polyethylene glycol 400 is 1:20. The injection has high stability and freezing resistance, and excellent effect in antibiosis and virus resistance, can effectively reduce generation of drug tolerance, and is particularly suitable for serious mixed infection of bacterium, virus and mycoplasma for animals. The invention also relates to a method for preparing the injection, and has the advantages of convenient operation, low cost and the like.

The invention provides a long-acting enrofloxacin injection for livestock and poultry which is prepared by the following raw materials by weight percentage: 2-15% of the enrofloxacin, 5-10% of cosolvent, 10-15% of sustained release solvent, 0.5-10% of macromolecule sustained release material, 0.01-0.03% of a complexing agent, 0.1-0.3% of antioxidant and 30-80% of water for injection; the long-acting enrofloxacin injection for livestock and poultry optimizes various ingredients, does not affect curative effect under the condition of reducing the total dosage, and lowers treatment cost as well as has the advantages of long-term action, high efficiency, low cost, safety and reliability; the preparation method of the long-acting enrofloxacin injection is simple, so the production cost is reduced. The long-acting enrofloxacin injection is suitable for various infectious diseases in digestive system, respiratory system, urinary system and skin soft tissues resulting from sensitive bacteria and mycoplasma of cattle, pigs, poultry, dogs, cats and aquatic animals.

The invention discloses an enrofloxacin injection, which comprises: 10-20% enrofloxacin, 10-20% polyethylene glycol 400, 10-20% meglumine, 20% hydrogen sodium oxide. It is prepared by the following steps: measure an appropriate amount of water for injection and heat it to 80°C, add the prescribed amount of meglumine and stir to dissolve, then add polyethylene glycol 400 and stir to dissolve, then add enrofloxacin and stir to dissolve, add an appropriate amount of 20% Sodium hydroxide solution was added dropwise until clarified, stirred evenly, adjusted to pH 9.5-10.5, coarsely filtered, finely filtered, filled with nitrogen, sterilized by autoclaving at 121°C for 20 minutes, inspected by light, and packaged. The invention provides a high-content enrofloxacin injection for veterinary clinics, has little irritation, good stability and long-acting effect.

The invention relates to the technical field of a pharmaceutical preparation for livestock and specifically discloses an enrofloxacin injection for the livestock and a preparation method thereof. The raw material of the injection is composed of enrofloxacin, artesunate, trimethoprim, flunixin meglumine, L-arginine, antioxidant, chelant, compound organic solvent and water for injection. The enrofloxacin injection for the livestock can effectively enhance the antibacterial effect of the drug, has an excellent anti-inflammatory effect and is mainly used for treating serious mixed infection caused by sensitive bacteria and mycoplasma of the livestock; the generation of drug resistance is effectively reduced; and the toxic and side effects are reduced. The preparation method for the enrofloxacin injection for the livestock provided by the invention is simple, low-cost, high in stability, convenient in use, and suitable for industrial production.

The invention provides an enrofloxacin injection, comprising following components: 2.5wt%-10wt% of enrofloxacin, 2wt%-10wt% of nicotinamide, 10wt%-30wt% of an organic solvent, 0.01wt%-0.05wt% of disodium ethylenediamine tetraacetic acid, 0.1wt%-0.5wt% of an antioxidant, 0.3wt%-1.4wt% of a pH regulator, and the balance water for injection. After being heated, part of the water for injection is mixed with the enrofloxacin, the nicotinamide, the organic solvent, the disodium ethylenediamine tetraacetic acid and the antioxidant, a mixture is obtained after dissolving, the mixture is mixed with the remaining water for injection after pH of the mixture is adjusted with the pH regulator, and the enrofloxacin injection is obtained. By using the enrofloxacin injection prepared, the technical problem that the enrofloxacin injection has poor stability at low temperature is solved, full play of the therapeutic effect of the enrofloxacin injection is facilitated, the enrofloxacin injection can pass the detection on the quality standard of enrofloxacin injections in Chinese veterinary pharmacopoeia 2010 and is a GB product, formulation cost is low, a production process is easy to operate, and the enrofloxacin injection is suitable for large-scale production in enterprises.

The invention discloses a preparation method of an enrofloxacin injection. The method comprises the steps as follows: (1) heating 40% of injection water to 80 DEG C by water, and adding a prescriptionamount of meglumine and hydroxymethyl cellulose to be dissolved; (2) dissolving a prescription amount of an antioxidant and a chelating agent by 20% of injection water, and adding the solution to thesolution in step (1) in a stirring state; (3) adding enrofloxacin and propylene glycol to the solution in step (2), mixing the substances, and performing ultrasonic treatment for 5-10 min; adding 8wt%-13wt% of acetic acid during ultrasonic treatment to adjust the pH value of the mixed solution to 5.4-6.8; (4) performing rough filtration by a 0.45 mu m microporous filtration membrane; (5) adding injection water to the total amount, and performing fine filtration by a 0.22 mu m microporous filtration membrane; (6) packaging the filtered solution. The preparation method effectively solves the technical problems of the existing enrofloxacin injection.