35 results about "Enrofloxacin Injectable Solution" patented technology

The invention provides a long-acting enrofloxacin injection for livestock and poultry which is prepared by the following raw materials by weight percentage: 2-15% of the enrofloxacin, 5-10% of cosolvent, 10-15% of sustained release solvent, 0.5-10% of macromolecule sustained release material, 0.01-0.03% of a complexing agent, 0.1-0.3% of antioxidant and 30-80% of water for injection; the long-acting enrofloxacin injection for livestock and poultry optimizes various ingredients, does not affect curative effect under the condition of reducing the total dosage, and lowers treatment cost as well as has the advantages of long-term action, high efficiency, low cost, safety and reliability; the preparation method of the long-acting enrofloxacin injection is simple, so the production cost is reduced. The long-acting enrofloxacin injection is suitable for various infectious diseases in digestive system, respiratory system, urinary system and skin soft tissues resulting from sensitive bacteria and mycoplasma of cattle, pigs, poultry, dogs, cats and aquatic animals.

The invention discloses a simple circulating water culture method and device of coreius guichenoti fries. The method comprises the following steps: A, constructing culture supporting facilities of coreius guichenoti fries, wherein the culture supporting facilities include an exogenous water treatment facility, culture equipment and a circulating water treatment system; B, adjusting and controllingthe water quality of water in a culture pool to obtain soft water of which the pH value is weakly alkaline; C, putting the coreius guichenoti fries into the pool, and then, feeding palatable bait according to different ages of the moon and mouth sizes of fishes; and D, preventing and treating fish diseases in a high-density culture process of the coreius guichenoti fries, namely spraying sea saltfor aquatic products, povidone-iodine, an enrofloxacin injection or hanging bag type chlorine dioxide effervescent tablets and isatis root powder in the whole pool so as to perform medication. The device is composed of an ozone generator, a pond, a culture pool, a water pump, an aerator, an ultraviolet sterilizer and a water pipe device. The method is easy to realize and simple and convenient tooperate, realizes intensive and efficient culture, fully utilizes limited purified water, and realizes a higher culture survival rate.

The invention aims at disclosing enrofloxacin injection. The injection comprises the following components according to weight percentage: 1%-10% of enrofloxacin, acid which is 0.1mol to 5mol more than the enrofloxacin or 0.1mol to 5mol of other mixed acid, preparation auxiliaries accounting for 0.1%-30% of a solution, and the balance of injection water. Compared with the prior art, the enrofloxacin injection functions rapidly as active substances achieve high blood concentration within a short time after being applied, and the active substances are also eliminated rapidly, so that the enrofloxacin injection is particularly suitable for treatment of animals serving as food products, and the purpose of the enrofloxacin injection is achieved.

The invention relates to an enrofloxacin injection. The enrofloxacin injection comprises, by weight, 21-25 parts of enrofloxacin, 5-15 parts of lactic acid, 0.1-0.5 part of sodium hydrogensulfite and 59.5-73.9 parts of water for injection. The enrofloxacin injection is faintly acid and can be compatible with most of acidic drugs; the concentration of the enrofloxacin is high and reaches 21-25%, so that the single administration dosage can be reduced, and stimulation and harm on animals are reduced; and besides, potential of hydrogen (pH) of the injection is 5.0-6.9, the range of the pH of the injection is identical to that of organism muscular tissue, the injection is small in stimulation, safe in clinical usage, obvious in curative effects and controllable in quality, curative effects of the enrofloxacin injection are better than those of existing products, and the whole preparation process is simple, practicable and applicable to modern mass production.

The invention relates to an enrofloxacin injection and a preparation method thereof. The enrofloxacin injection comprises 4%-6% of enrofloxacin, 18%-20% of benzyl alcohol, 3%-6% of polyvinylpyrrolidone, 1%-2% of anhydrous sodium sulfite and the balance of water for injection. The preparation method of the enrofloxacin injection comprises the following steps of: taking a proper amount of water for injection, polyvinylpyrrolidone and benzyl alcohol, introducing air and heating to 80 DEG C; stirring and adding the anhydrous sodium sulfite dissolved in the water for injection to the mixed solution; stirring and dissolving the enrofloxacin in the solution, filtering the solution, adding the water for injection to the whole weight, and regulating the PH value. The enrofloxacin injection has the advantages of wide antibacterial spectrum, slow-release antibacterial action and is effective to bacteria in stationary periods and growth periods and is an effective antibacterial medicament for livestock and poultry.

The invention relates to a veterinary compound enrofloxacin injection and a preparation method thereof. The veterinary compound enrofloxacin injection mainly comprises enrofloxacin, sulfamethoxazole,trimethoprim, flunixin meglumine, tylosin, organic solvent and water for injection. The veterinary compound enrofloxacin injection is used as a veterinary special compound preparation, used for treating various infectious diseases of a respiratory system, a digestive system and a skin soft tissue caused by livestock and poultry bacterial and mycoplasma infection, particularly has special effects on secondary hemophilus disease of pigs and poultries caused by hemophilus and has the advantages of convenient use, short course, low drug resistance and the like.

The invention relates to an acidic enrofloxacin injection and a preparation method thereof. The acidic enrofloxacin injection comprises the following components: 5g of enrofloxacin, 1.25g of acetic acid, 1ml of benzyl alcohol, 0.5-5 percent of lincomycin hydrochloride and 100ml of injection water. The weights of all components can be changed according to the accurate proportion of the materials and the solution. The preparation method of the injection comprises the following steps of: taking 5g of enrofloxacin to be added into 80-90ml of injection water, stirring, heating to 50-60 DEG C, cooling, adding 1.25g of acetic acid and 1ml of benzyl alcohol, stirring uniformly, then adding 0.5-5g of lincomycin hydrochloride, stirring until dissolving, finally adding the injection water until reaching 100ml, canning, and sterilizing at high pressure.

The invention provides an enrofloxacin injection, comprising following components: 2.5wt%-10wt% of enrofloxacin, 2wt%-10wt% of nicotinamide, 10wt%-30wt% of an organic solvent, 0.01wt%-0.05wt% of disodium ethylenediamine tetraacetic acid, 0.1wt%-0.5wt% of an antioxidant, 0.3wt%-1.4wt% of a pH regulator, and the balance water for injection. After being heated, part of the water for injection is mixed with the enrofloxacin, the nicotinamide, the organic solvent, the disodium ethylenediamine tetraacetic acid and the antioxidant, a mixture is obtained after dissolving, the mixture is mixed with the remaining water for injection after pH of the mixture is adjusted with the pH regulator, and the enrofloxacin injection is obtained. By using the enrofloxacin injection prepared, the technical problem that the enrofloxacin injection has poor stability at low temperature is solved, full play of the therapeutic effect of the enrofloxacin injection is facilitated, the enrofloxacin injection can pass the detection on the quality standard of enrofloxacin injections in Chinese veterinary pharmacopoeia 2010 and is a GB product, formulation cost is low, a production process is easy to operate, and the enrofloxacin injection is suitable for large-scale production in enterprises.

The invention provides a long-acting Enrofloxacin Injection, which is formulated by the following raw materials by weight percentage: 5-13 percent of Enrofloxacin, 1-6 percent of phenylcarbinol, 2-5 percent of polyvinylpyrrolidone, 30-45 percent of sodium hydroxide solution, 0.5-2 percent of neovaricaine, 0.05-0.1 percent of thiourea and the rest of injection water, the concentration of the sodium hydroxide solution is 10-20 percent by mass percent; the long-acting Enrofloxacin Injection is added with polyvinylpyrrolidone as slow release material, and the slow release material is evenly dispersed in treatment drugs, thus leading the drugs to be slowly released after entering an animal organism, prolonging the half-life of the drugs, maintaining effective blood concentration for a long period, reducing or avoiding the side effects caused by the fluctuation of 'peak valley' of blood concentration and achieving the purpose of being high-efficiency, long-acting and stable.

The invention provides a preparation method of a slow-released enrofloxacin injection, and belongs to a slow-released injection for animals. The enrofloxacin injection is prepared from, by weight, 5%-20% of enrofloxacin, 1%-4% of fatty acid, 5%-35% of stabilizer and the balance organic solvent. The preparation method comprises the steps that enrofloxacin and the organic solvent are taken and stirred for dissolution, the fatty acid is added to conduct a complexation reaction with a dissolved product, the stabilizer is added, after sufficient dissolution is achieved, the organic solvent is added for the scale volume, and the slow-released enrofloxacin injection is obtained after membrane filtration is conducted. According to the preparation method of the slow-released enrofloxacin injection, enrofloxacin or a salt hydrate thereof is reacted with the fatty acid to form a new compound, the release time of enrofloxacin can be prolonged, the effective blood drug concentration of a drug in an animal body can be maintained for a long time, and therefore the purposes of decreasing the frequency of drug delivery and reducing drug stress are achieved.

The invention provides a fluoroquinolone medicine composition. Every 100ml of fluoroquinolone medicine composition comprises the following components by weight: 10-30g of fluoroquinolone, 0.1-20g of cosolvent, 0-60g of water and the balance of organic solvent, wherein the cosolvent is a pharmaceutically acceptable acid cosolvent. The fluoroquinolone medicine composition provided by the invention has the advantages that the content of the fluoroquinolone medicine is greatly increased and the treating effect of one-time administration is greatly improved; since the organic solvent is adopted as the main solvent, compared with the conventional enrofloxacin injection liquid, the irritation of intramuscular injection is reduced; the prepared fluoroquinolone medicine composition is stable in character, and has no crystal precipitation after long-time storage; a preparation method is simple, is easy to operate and is easy for industrial large-scale production.

The invention provides a long-acting Enrofloxacin Injection, which is formulated by the following raw materials by weight percentage: 5-13 percent of Enrofloxacin, 1-6 percent of phenylcarbinol, 2-5 percent of polyvinylpyrrolidone, 30-45 percent of sodium hydroxide solution, 0.5-2 percent of neovaricaine, 0.05-0.1 percent of thiourea and the rest of injection water, the concentration of the sodium hydroxide solution is 10-20 percent by mass percent; the long-acting Enrofloxacin Injection is added with polyvinylpyrrolidone as slow release material, and the slow release material is evenly dispersed in treatment drugs, thus leading the drugs to be slowly released after entering an animal organism, prolonging the half-life of the drugs, maintaining effective blood concentration for a long period, reducing or avoiding the side effects caused by the fluctuation of 'peak valley' of blood concentration and achieving the purpose of being high-efficiency, long-acting and stable.

The invention relates to the field of veterinary medicament, in particular to a veterinary synergic enrofloxacin injection. Based on the total amount of 100mL, the injection comprises the following components by weight: 5 to 10g of enrofloxacin, 10 to 12g of sodium salicylate, water extract of 20 to 40g of isatis root, 1 to 2g of trimethoprim, 20 to 40g of polyethylene glycol 400, 0.1 to 1g of sodium hydroxide, and the balance injection water, wherein the mass ratio of the enrofloxacin to the trimethoprim is 5 to 1; and the mass ratio of the trimethoprim to the polyethylene glycol 400 is 1:20. The injection has high stability and freezing resistance, and excellent effect in antibiosis and virus resistance, can effectively reduce generation of drug tolerance, and is particularly suitable for serious mixed infection of bacterium, virus and mycoplasma for animals. The invention also relates to a method for preparing the injection, and has the advantages of convenient operation, low cost and the like.

The invention discloses veterinary enrofloxacin injection and a preparation method thereof, belonging to the technical field of preparation of veterinary drugs. The veterinary enrofloxacin injection is prepared from the following raw materials in percentage by weight: 2-20 percent of enrofloxacin, 2-30 percent of L-arginine alkali, 10-30 percent of a pH value regulator, 0.1-0.2 percent of an antioxidant, 0.01-0.02 percent of a chelating agent, 10-50 percent of an organic solvent, 1-13 percent of a cosolvent, 1-5 percent of a controlled release formulation and the balance of water for injection. The veterinary enrofloxacin injection is high in stability, low in cost and safe and convenient to use and has the advantages of long-acting effect, high efficiency and low drug tolerance. Moreover, the veterinary enrofloxacin injection is compatible with L-arginine alkali to achieve a special effect of treating mixed infection caused by sensitive bacteria and mycoplasma of beasts and birds.

The invention discloses enrofloxacin injection which comprises the followings in weight percentage: 10-20% of enrofloxacin, 10-20% of polyethylene glycol 400, 10-20% of meglumine and 20% of sodium hydroxide. The enrofloxacin injection is prepared through the following steps: measuring a proper amount of water for injection, heating the water to 80 DEG C, adding meglumine according to the formulated amount, stirring for dissolution, adding polyethylene glycol 400, stirring for dissolution, adding enrofloxacin, stirring for dissolution, dropwise adding a proper amount of 20% sodium hydroxide solution till clarification, uniformly stirring, adjusting pH to 9.5-10.5, performing rough filtration and refined filtration, filling nitrogen for encapsulation, performing hot-pressing sterilization for 20 minutes at 121 DEG C, performing light inspection, and packaging. According to the invention, high-content enrofloxacin injection for veterinarian clinic is provided, small in irritation and excellent in stability, and has a long-acting function.

The invention provides a long-acting enrofloxacin injection for livestock and poultry which is prepared by the following raw materials by weight percentage: 2-15% of the enrofloxacin, 5-10% of cosolvent, 10-15% of sustained release solvent, 0.5-10% of macromolecule sustained release material, 0.01-0.03% of a complexing agent, 0.1-0.3% of antioxidant and 30-80% of water for injection; the long-acting enrofloxacin injection for livestock and poultry optimizes various ingredients, does not affect curative effect under the condition of reducing the total dosage, and lowers treatment cost as well as has the advantages of long-term action, high efficiency, low cost, safety and reliability; the preparation method of the long-acting enrofloxacin injection is simple, so the production cost is reduced. The long-acting enrofloxacin injection is suitable for various infectious diseases in digestive system, respiratory system, urinary system and skin soft tissues resulting from sensitive bacteria and mycoplasma of cattle, pigs, poultry, dogs, cats and aquatic animals.

The invention discloses a method for preparing an enrofloxacin injection, and belongs to the technical field of veterinary drugs. The injection comprises the following components: enrofloxacin, sodiumhydrogen sulfite, propylene glycol, ethyl alcohol, EDTA, sodium hydroxide and water for injection. The method for preparing the enrofloxacin injection comprises the following steps: the sodium hydrogen sulfite, the EDTA and the sodium hydroxide are dissolved with part of water for injection, respectively, then, the propylene glycol is taken and heated, the sodium hydrogen sulfite aqueous solutionand the EDTA aqueous solution are added, stirring is conducted, the sodium hydroxide solution is added, stirring is carried out, the enrofloxacin is added, stirring is carried out, finally, the ethylalcohol and remaining water for injection are added, stirring is carried out, adsorption is conducted by adding activated carbon, and filtration is carried out to obtain the enrofloxacin injection. By means of the enrofloxacin injection, the technical problems that an existing enrofloxacin injection is poor in stability and prone to precipitation and crystallization in a low-temperature environment are solved, the drug effects are given full play, and the formula cost is low. Besides, the method for preparing the enrofloxacin injection is simple, low in production cost and suitable for production application.

The invention relates to a live pig feeding technique, in particular to a feeding method capable of improving male piglet castration survival rate. The feeding method comprises the step of periodical breast feeding by a mother pig, and is characterized in that the feeding method additionally comprises the following steps of: from the first day after male piglets are born, continuously feeding one milliliter of enrofloxacin injection to each male piglet once a day for three days, and feeding two milliliters of iron supplementary to each male piglet at the same time from the second day after the male piglets are born; and from the fourth day, continuously feeding two milliliters of heartleaf houttuynia herb liquid medicine to each male piglet once a day for three days. By adopting the method provided by the invention to feed the male piglets, the male piglets can recover rapidly after the male piglets are castrated on the seventh day, the death rate is greatly reduced, the method is safe and high-efficiency and the economic benefits of enterprises are greatly improved.

The invention provides an enrofloxacin injection, comprising following components: 2.5wt%-10wt% of enrofloxacin, 2wt%-10wt% of nicotinamide, 10wt%-30wt% of an organic solvent, 0.01wt%-0.05wt% of disodium ethylenediamine tetraacetic acid, 0.1wt%-0.5wt% of an antioxidant, 0.3wt%-1.4wt% of a pH regulator, and the balance water for injection. After being heated, part of the water for injection is mixed with the enrofloxacin, the nicotinamide, the organic solvent, the disodium ethylenediamine tetraacetic acid and the antioxidant, a mixture is obtained after dissolving, the mixture is mixed with the remaining water for injection after pH of the mixture is adjusted with the pH regulator, and the enrofloxacin injection is obtained. By using the enrofloxacin injection prepared, the technical problem that the enrofloxacin injection has poor stability at low temperature is solved, full play of the therapeutic effect of the enrofloxacin injection is facilitated, the enrofloxacin injection can pass the detection on the quality standard of enrofloxacin injections in Chinese veterinary pharmacopoeia 2010 and is a GB product, formulation cost is low, a production process is easy to operate, and the enrofloxacin injection is suitable for large-scale production in enterprises.

The present invention relates to an enrofloxacin injection and a production method thereof. The enrofloxacin injection comprises enrofloxacin with a concentration of 48-52 g / L, sodium hydroxide with a concentration of 5.5-6.5 g / L, propylene glycol with a concentration of 180-220 g / L, sodium sulfite with a concentration of 1.9-2.1 g / L, and a solvent, wherein the solvent is water for injection. According to the present invention, the use amount of the propylene glycol is increased in the formula or the production process of the enrofloxacin injection, such that the product is stable, and the quality of the product is ensured; specifically various detected indexes are qualified and especially the crystallization problem is effectively solved after the product is stored for more than 2 years; and the product meet the quality standard of the enrofloxacin injection in the new Veterinary Pharmacopoeia of the People's Republic of China, the storage time is prolonged, and it is ensured that various indexes are qualified within the validity period.

The invention discloses enrofloxacin injection. The enrofloxacin injection is prepared from, by weight, 2.5-10 parts of enrofloxacin injection, 2-8 parts of meglumine, 0.2-0.5 part of alpha- mannatide, 10-30 parts of propylene glycol, 0.01-0.05 part of EDTA, 0.5-0.9 part of sodium hydroxide, and 70-80 parts of water for injection. The enrofloxacin injection is quick to absorb after injection, long in elimination half-life, high in bioavailability, and good in stability; during the injection, the aching feeling can be reduced; the enrofloxacin injection solves the technical difficulty of poor stability under the low temperature, and is good for the fully display of the treatment effect of the enrofloxacin injection; moreover, the formula cost is low, and the manufacturing process is easy to operate; therefore, the enrofloxacin injection is suitable for large-scale production of enterprises.

The invention provides a fluoroquinolone pharmaceutical composition, each 100ml pharmaceutical composition contains: fluoroquinolone 10g-30g, cosolvent 0.1g-20g, water 0g-60g, and the balance is an organic solvent, wherein the cosolvent is A pharmaceutically acceptable acidic cosolvent. The fluoroquinolone drug content in the fluoroquinolone pharmaceutical composition provided by the invention is greatly improved, greatly increasing the therapeutic effect of a single administration; using an organic solvent as the main solvent, compared with conventional enrofloxacin injection, it reduces the intramuscular injection irritation; the prepared fluoroquinolone pharmaceutical composition has stable properties and no crystallization during long-term storage; the preparation method is simple and easy to operate, and is easy to realize industrialized large-scale production.

The invention discloses a preparation method of an enrofloxacin injection. The method comprises the steps as follows: (1) heating 40% of injection water to 80 DEG C by water, and adding a prescriptionamount of meglumine and hydroxymethyl cellulose to be dissolved; (2) dissolving a prescription amount of an antioxidant and a chelating agent by 20% of injection water, and adding the solution to thesolution in step (1) in a stirring state; (3) adding enrofloxacin and propylene glycol to the solution in step (2), mixing the substances, and performing ultrasonic treatment for 5-10 min; adding 8wt%-13wt% of acetic acid during ultrasonic treatment to adjust the pH value of the mixed solution to 5.4-6.8; (4) performing rough filtration by a 0.45 mu m microporous filtration membrane; (5) adding injection water to the total amount, and performing fine filtration by a 0.22 mu m microporous filtration membrane; (6) packaging the filtered solution. The preparation method effectively solves the technical problems of the existing enrofloxacin injection.

The invention discloses non-aqueous solvent long-acting enrofloxacin injection liquid. According to the formula, the injection liquid is prepared from, by mass, 10-20 %(w / v) of enrofloxacin, 80-85 %(w / v) of oily solvent, 10-20 %(w / v) of solubilizer, 10-20 %(w / v) of local anesthetic, 1-5 %(w / v) of suspending agent and 0.8-2 %(w / v) of anti-oxidation aid, wherein a mixture of ethyl oleate, coix seedoil and cottonseed oil is adopted as the oily solvent. The preparation process of the enrofloxacin injection liquid comprises the steps that a prescribed amount of oily solvent is added to a liquid mixing tank, the suspending agent is heated and dissolved, the anti-oxidation aid is added after cooling, and stirring is conducted evenly to obtain a mixed solution for use; the local anesthetic is added in a liquid mixing barrel, enrofloxacin is added, and the solubilizer is added to assist in solubilization; after dissolution, the mixture in the liquid mixing barrel is added to the mixed solution, and mixing is conducted evenly to obtain the injection liquid. By adopting the further optimization of all the components and ratio, the injection liquid has no stress reaction, a drug library can be formed in the injection part, and the long-acting and high-efficiency effect is exerted.

The invention relates to the field of pig breeding industry, in particular to a pig semen purifying agent. The pig semen purifying agent is prepared from the following raw materials: 15 to 25 grams of glucose, 6 to 16 grams of trisodium citrate, 1 to 5 grams of disodium ethylene diamine tetraacetate, 0.5 to 3.5 grams of sodium bicarbonate, 0.5 to 1.5 grams of polyvinyl alcohol, 2 to 11 grams of tricarboxymethyl aminomethane, 1 to 8 grams of citric acid, 0.1 to 0.3 gram of cysteine, 0.05 to 0.15 ml of a ribavirin injection, 0.05 to 0.15 ml of an enrofloxacin injection, 0.05 to 0.15 ml of a radix bupleuri injection and 800 to 1200 ml of deionized water. According to the technology, the broad-spectrum antibacterial agent and the Chinese herbal medicine extracting solution are added in the semen dilution process, so that stealth poison of the semen and bacteria bred in the semen collection and dilution process are relieved and purified, the semen quality is optimized, and the breeding performance is improved.

The invention discloses a preparation method of an enrofloxacin injection. The method comprises the steps as follows: (1) heating 40% of injection water to 80 DEG C by water, and adding a prescriptionamount of meglumine and hydroxymethyl cellulose to be dissolved; (2) dissolving a prescription amount of an antioxidant and a chelating agent by 20% of injection water, and adding the solution to thesolution in step (1) in a stirring state; (3) adding enrofloxacin and propylene glycol to the solution in step (2), mixing the substances, and performing ultrasonic treatment for 5-10 min; adding 8wt%-13wt% of acetic acid during ultrasonic treatment to adjust the pH value of the mixed solution to 5.4-6.8; (4) performing rough filtration by a 0.45 mu m microporous filtration membrane; (5) adding injection water to the total amount, and performing fine filtration by a 0.22 mu m microporous filtration membrane; (6) packaging the filtered solution. The preparation method effectively solves the technical problems of the existing enrofloxacin injection.