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Enrofloxacin injection and preparation method thereof

A technology of enrofloxacin and injection, which is applied in the field of enrofloxacin injection and its preparation, can solve the problems of restricting the scope of clinical application of enrofloxacin injection, unfavorable clinical drug compatibility, low concentration of enrofloxacin, etc. problem, to achieve the effect of reducing single administration dose, simple and feasible preparation process, and reducing irritation and injury

Inactive Publication Date: 2012-11-14
挑战(天津)动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, most of the clinical cases are mixed infections, which require compatible medications. Currently, enrofloxacin injections are alkaline preparations or neutral preparations, which cannot be used in combination with many acidic drugs, which is not conducive to clinical drug compatibility, and restricts enrofloxacin. The scope of clinical application of injections; at present, although acidic enrofloxacin injections also exist, due to the low concentration of enrofloxacin, the number of administrations is increased, the cost is increased, resources are wasted, and the preparation method is relatively complicated

Method used

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  • Enrofloxacin injection and preparation method thereof
  • Enrofloxacin injection and preparation method thereof
  • Enrofloxacin injection and preparation method thereof

Examples

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Effect test

preparation example Construction

[0057] The preparation method of above-mentioned enrofloxacin injection, the steps are as follows:

[0058] (1) Weigh the water for injection for dissolving various medicaments;

[0059] ⑵Add antioxidant and stir until completely dissolved;

[0060] (3) Add the main ingredient and stir evenly;

[0061] (4) Add co-solvent and stir until the solution is clear;

[0062] (5) Add the remaining water for injection to the full amount, filter, subpackage, and sterilize to obtain enrofloxacin injection.

Embodiment 1

[0064] A kind of enrofloxacin injection, its composition and parts by weight are as follows:

[0065] Enrofloxacin 21g;

[0066] Lactic acid 5g;

[0067] Sodium bisulfite 0.1g;

[0068] Water for injection 73.9g.

[0069] The preparation method of above-mentioned enrofloxacin injection, the steps are as follows:

[0070] (1) Weigh 50g of water for injection;

[0071] (2) Add 0.1 g of sodium bisulfite to the solution in step (1), and stir until completely dissolved;

[0072] (3) Add 21 g of enrofloxacin to the solution in step (2), and stir evenly;

[0073] (4) Add 5 g of lactic acid to the step (3) solution, and stir until the solution is clarified;

[0074] (5) Add the remaining water for injection to the solution in step (4) to 100 g, filter, subpackage, and sterilize to obtain enrofloxacin injection.

Embodiment 2

[0076] A kind of enrofloxacin injection, its composition and parts by weight are as follows:

[0077] Enrofloxacin 22g;

[0078] Lactic acid 8g;

[0079] Sodium bisulfite 0.2g;

[0080] Water for injection 69.8g.

[0081] The preparation method of above-mentioned enrofloxacin injection, the steps are as follows:

[0082] (1) Weigh 50g of water for injection;

[0083] (2) Add 0.2 g of sodium bisulfite to the solution in step (1), and stir until completely dissolved;

[0084] (3) Add 22 g of enrofloxacin to the solution in step (2), and stir evenly;

[0085] (4) Add 8 g of lactic acid to the step (3) solution, and stir until the solution is clarified;

[0086] (5) Add the remaining water for injection to the solution in step (4) to 100 g, filter, subpackage, and sterilize to obtain enrofloxacin injection.

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Abstract

The invention relates to an enrofloxacin injection. The enrofloxacin injection comprises, by weight, 21-25 parts of enrofloxacin, 5-15 parts of lactic acid, 0.1-0.5 part of sodium hydrogensulfite and 59.5-73.9 parts of water for injection. The enrofloxacin injection is faintly acid and can be compatible with most of acidic drugs; the concentration of the enrofloxacin is high and reaches 21-25%, so that the single administration dosage can be reduced, and stimulation and harm on animals are reduced; and besides, potential of hydrogen (pH) of the injection is 5.0-6.9, the range of the pH of the injection is identical to that of organism muscular tissue, the injection is small in stimulation, safe in clinical usage, obvious in curative effects and controllable in quality, curative effects of the enrofloxacin injection are better than those of existing products, and the whole preparation process is simple, practicable and applicable to modern mass production.

Description

technical field [0001] The invention belongs to the field of chemical preparations, in particular to an enrofloxacin injection and a preparation method thereof. Background technique [0002] Enrofloxacin (ERFX) is a third-generation quinolone drug, which is a special antibacterial drug for animals and is widely used in the prevention and treatment of various animal infectious diseases. Enrofloxacin against Escherichia coli, Salmonella, Klebsiella, Pasteurella, Actinomyces pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Botella septicemia , Staphylococcus aureus, Mycoplasma, Chlamydia, etc. all have good effects. Enrofloxacin can be used for digestive system, respiratory system, urinary system and skin and soft tissue infectious diseases caused by sensitive bacteria and mycoplasma in pigs, cattle, poultry, dogs and cats. [0003] Enrofloxacin introduces a fluorine atom at the 6-position of the quinolone structure, which enhances the aff...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/496A61P31/04
Inventor 程雪娇王建焦小军王勇余贵菊
Owner 挑战(天津)动物药业有限公司
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