Long-acting enrofloxacin injection for livestock and poultry and method of preparing the same

Abstract

The invention provides a long-acting enrofloxacin injection for livestock and poultry which is prepared by the following raw materials by weight percentage: 2-15% of the enrofloxacin, 5-10% of cosolvent, 10-15% of sustained release solvent, 0.5-10% of macromolecule sustained release material, 0.01-0.03% of a complexing agent, 0.1-0.3% of antioxidant and 30-80% of water for injection; the long-acting enrofloxacin injection for livestock and poultry optimizes various ingredients, does not affect curative effect under the condition of reducing the total dosage, and lowers treatment cost as well as has the advantages of long-term action, high efficiency, low cost, safety and reliability; the preparation method of the long-acting enrofloxacin injection is simple, so the production cost is reduced. The long-acting enrofloxacin injection is suitable for various infectious diseases in digestive system, respiratory system, urinary system and skin soft tissues resulting from sensitive bacteria and mycoplasma of cattle, pigs, poultry, dogs, cats and aquatic animals.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a long-acting enrofloxacin injection for livestock and poultry, and also relates to a preparation method of the injection. Background technique [0002] Since the implementation of the market economy system reform in the early 1980s to the 21st century, my country's animal husbandry has experienced a period of rapid development, but the hazards of livestock and poultry diseases have become increasingly prominent, seriously affecting the healthy development of animal husbandry. The number of new diseases is increasing, and the harm is also increasing, which not only causes serious economic losses to the breeding enterprises, but also poses a threat to the physical and mental health of consumers. In the past two decades, my country's animal drug industry has entered a period of comprehensive development, and veterinary drug research has made great progress. Howe...

AI Technical Summary

Problems solved by technology

In the past two decades, my country's animal drug industry has entered a period of comprehensive development, and veterinary drug research has made great progress. However, compared with some developed countries, there is still a big gap. The types and quality of new veterinary drugs on the market cannot meet the current requirements. The needs of the development of my country's livestock and poultry breeding industry

[0003] Enrofloxacin is a representative of quinolone antibacterial drugs and is a special drug for livestock and poultry. It not only retains the characteristics of broad spectrum, high efficiency, low toxicity, good absorption and convenient administration of quinolones, but also is effective against various diseases caused by various bacteria. This kind of infection has remarkable curative effect, especially the lethality to various mycoplasma is significantly higher than other drugs of quinolones and various drugs such as tylosin and tiomycin that have been used for many years, but the existing enrofloxacin is The short-acting dosage form has the following defects during administration: due to the short half-life of the short-acting dosage form and the short duration of the drug effect, in order to fully exert its therapeutic effect, repeated administration in a short period of time is required, and the large amount of drug used leads to The cost is high, and the large amount of drug also causes a lot of drug residues in the animal body, and it is troublesome to administer several times

At present, some long-acting enrofloxacin injections have appeared, but the therapeutic effect is found to be unsatisfactory when used, and it needs to be used continuously for 3 to 5 days, and injected once a day, which will also cause large drug residues in animals