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Enrofloxacin injection

A technology of enrofloxacin and injection, applied in the field of livestock and poultry antibacterial drugs, can solve the problems of short elimination half-life, poor stability of enrofloxacin, strong pain, etc., and achieve the effect of remarkable curative effect.

Inactive Publication Date: 2010-12-15
广州天王动物保健品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the basic composition of current enrofloxacin medicament is the sterilized aqueous solution of enrofloxacin, and its shortcoming is that formula is single, and absorption after injection is slow, and elimination half-life is short, and bioavailability is low; Its manufacturing process is to take enrofloxacin Add water to 5 grams of star to 100ml, after heating and dissolving, adjust the pH value to 9.5~10.5 with sodium hydroxide, and pack it separately. The enrofloxacin produced by this method has poor stability and high alkalinity. strong pain

Method used

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Examples

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Comparison scheme
Effect test

Embodiment 1

[0079] Enrofloxacin injection is made from the following raw materials calculated by weight percentage:

[0080] Enrofloxacin 5.5%;

[0081] Benzyl alcohol 19%;

[0082] Polyvinylpyrrolidone 5.5%;

[0083] Anhydrous sodium sulfite 1.8%;

[0084] Add water for injection to the full amount.

Embodiment 2

[0086] Enrofloxacin injection is made from the following raw materials calculated by weight percentage:

[0087] Enrofloxacin 4%;

[0088] Benzyl alcohol 18%;

[0089] Polyvinylpyrrolidone 3%;

[0090] Anhydrous sodium sulfite 1%;

[0091] Add water for injection to the full amount.

Embodiment 3

[0093] Enrofloxacin injection is made from the following raw materials calculated by weight percentage:

[0094] Enrofloxacin 4.5%;

[0095] Benzyl alcohol 18.5%;

[0096] Polyvinylpyrrolidone 3.5%;

[0097] Anhydrous sodium sulfite 1.2%;

[0098] Add water for injection to the full amount.

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Abstract

The invention relates to an enrofloxacin injection and a preparation method thereof. The enrofloxacin injection comprises 4%-6% of enrofloxacin, 18%-20% of benzyl alcohol, 3%-6% of polyvinylpyrrolidone, 1%-2% of anhydrous sodium sulfite and the balance of water for injection. The preparation method of the enrofloxacin injection comprises the following steps of: taking a proper amount of water for injection, polyvinylpyrrolidone and benzyl alcohol, introducing air and heating to 80 DEG C; stirring and adding the anhydrous sodium sulfite dissolved in the water for injection to the mixed solution; stirring and dissolving the enrofloxacin in the solution, filtering the solution, adding the water for injection to the whole weight, and regulating the PH value. The enrofloxacin injection has the advantages of wide antibacterial spectrum, slow-release antibacterial action and is effective to bacteria in stationary periods and growth periods and is an effective antibacterial medicament for livestock and poultry.

Description

technical field [0001] The invention relates to an antibacterial drug for livestock and poultry, in particular to a special fluoroquinolone drug for livestock and poultry, and also relates to a preparation method of the drug. Background technique [0002] Enrofloxacin, also known as ethyl cyclopropyl (norfloxacin) is the first fluoroquinolone (Flu roqu ino lones) drug for livestock and poultry. The English name is Enrofloxacin, which is the ethyl compound of ciprofloxacin , is the third generation of fluoroquinolones, has a broad-spectrum bactericidal effect, and is effective against bacteria in the stationary phase and the growth phase. [0003] Enrofloxacin was first successfully developed by Bayer in Germany in the 1980s, and has entered most countries and markets in the world. It was successfully developed in my country in 1993 and has been widely used in veterinary clinics. Enrofloxacin has the characteristics of broad antibacterial spectrum, strong bactericidal act...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/32A61P31/04
Inventor 许平顺
Owner 广州天王动物保健品有限公司
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