Veterinary ideproline-sulfamethoxazole compound injection and preparation method
A technology of sulfamethoxazole and compound injection, which is applied in the field of ideproline-sulfamethoxazole compound injection and its preparation for veterinary use, and can solve the problem of apparent volume of distribution that is not suitable for the treatment of systemic infection Small, can not achieve long-term antibacterial and other problems, to achieve the effect of increasing the apparent volume of distribution, reliable quality, and reducing dosage
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Embodiment 1
[0047] Example 1 Veterinary Elliprine-Sulfamethoxazole Injection Preparation Process-1
[0048] The specific process steps are as follows:
[0049] (1) Add a small amount of water for injection (1 mL) to the ideproline bulk drug (0.2 g), and then add lactic acid (295 μl) to form a salt, which is the salt-forming system 1;
[0050] (2) salt sulfamethoxazole (1 g) with triethanolamine (1340 μl) to form the salt-forming system 2;
[0051] (3) Add propylene glycol (4.5mL) to the salt-forming system 2 of step (2), and stir to make it fully dissolve, and put it at room temperature for later use;
[0052] (4) Mix the two salt-forming systems of step (1) and step (3), and stir to make it fully dissolve, which is a mixed system;
[0053] (5) Add antioxidant anhydrous sodium thiosulfate (0.005g) into the mixing system of step (4), and stir to make it fully dissolve;
[0054] (6) Constant volume with water for injection;
[0055] (7) Carry out coarse filtration and fine filtration with...
Embodiment 2
[0058] Example 2 Veterinary Elliprine-Sulfamethoxazole Injection Preparation Process-2
[0059] The specific process steps are as follows:
[0060] (1) Add a small amount of 1 mL of water for injection to Idiproline (0.2 g), and then add lactic acid (300 μl) to form a salt, which is the salt-forming system 1;
[0061] (2) Salt-forming sulfamethoxazole (1 g) with triethanolamine (1340 μl), which is the salt-forming system 2;
[0062] (3) Add propylene glycol (5mL) to the salt-forming system of step (2), and stir to make it fully dissolve, and put it at room temperature for subsequent use;
[0063] (4) Mix the two salt-forming systems of step (1) and step (3), and stir to make it fully dissolve, which is a mixed system;
[0064] (5) Add antioxidant anhydrous sodium thiosulfate (0.0075g) to the mixed system of step (4), and stir to make it fully dissolve;
[0065] (6) Constant volume with water for injection;
[0066] (7) Carry out coarse filtration and fine filtration with o...
Embodiment 3
[0069] Example 3 Veterinary Elliprine-Sulfamethoxazole Injection Preparation Process-3
[0070] The specific process steps are as follows:
[0071] (1) Add a small amount of 1 mL of water for injection to Idiproline (0.2 g), and then add lactic acid (305 μl) to form a salt, which is the salt-forming system 1;
[0072] (2) Salt-forming sulfamethoxazole (1 g) with triethanolamine (1340 μl), which is the salt-forming system 2;
[0073] (3) Add propylene glycol (5.5mL) to the salt-forming system 2 of step (2), and stir to make it fully dissolve, and put it at room temperature for later use;
[0074] (4) Mix the two salt-forming systems of step (1) and step (3), and stir to make it fully dissolve, which is a mixed system;
[0075] (5) Add antioxidant anhydrous sodium thiosulfate (0.01g) into the mixing system of step (4), and stir to make it fully dissolve;
[0076] (6) Constant volume with water for injection;
[0077] (7) Carry out coarse filtration and fine filtration with o...
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