Veterinary ideproline-sulfamethoxazole compound injection and preparation method

A technology of sulfamethoxazole and compound injection, which is applied in the field of ideproline-sulfamethoxazole compound injection and its preparation for veterinary use, and can solve the problem of apparent volume of distribution that is not suitable for the treatment of systemic infection Small, can not achieve long-term antibacterial and other problems, to achieve the effect of increasing the apparent volume of distribution, reliable quality, and reducing dosage

Active Publication Date: 2016-11-23
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the compound preparation made of sulfamethoxazole (SMZ) and trimethoprim (TMP) is the most antibacterial and more commonly used sulfonamides, but there are some problems in this compound preparation: The biological half-life is relatively short, and the long-term antibacterial effect cannot be achieved; the apparent distribution volume is small, and it is not suitable for the treatment of systemic infections

Method used

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  • Veterinary ideproline-sulfamethoxazole compound injection and preparation method
  • Veterinary ideproline-sulfamethoxazole compound injection and preparation method
  • Veterinary ideproline-sulfamethoxazole compound injection and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Veterinary Elliprine-Sulfamethoxazole Injection Preparation Process-1

[0048] The specific process steps are as follows:

[0049] (1) Add a small amount of water for injection (1 mL) to the ideproline bulk drug (0.2 g), and then add lactic acid (295 μl) to form a salt, which is the salt-forming system 1;

[0050] (2) salt sulfamethoxazole (1 g) with triethanolamine (1340 μl) to form the salt-forming system 2;

[0051] (3) Add propylene glycol (4.5mL) to the salt-forming system 2 of step (2), and stir to make it fully dissolve, and put it at room temperature for later use;

[0052] (4) Mix the two salt-forming systems of step (1) and step (3), and stir to make it fully dissolve, which is a mixed system;

[0053] (5) Add antioxidant anhydrous sodium thiosulfate (0.005g) into the mixing system of step (4), and stir to make it fully dissolve;

[0054] (6) Constant volume with water for injection;

[0055] (7) Carry out coarse filtration and fine filtration with...

Embodiment 2

[0058] Example 2 Veterinary Elliprine-Sulfamethoxazole Injection Preparation Process-2

[0059] The specific process steps are as follows:

[0060] (1) Add a small amount of 1 mL of water for injection to Idiproline (0.2 g), and then add lactic acid (300 μl) to form a salt, which is the salt-forming system 1;

[0061] (2) Salt-forming sulfamethoxazole (1 g) with triethanolamine (1340 μl), which is the salt-forming system 2;

[0062] (3) Add propylene glycol (5mL) to the salt-forming system of step (2), and stir to make it fully dissolve, and put it at room temperature for subsequent use;

[0063] (4) Mix the two salt-forming systems of step (1) and step (3), and stir to make it fully dissolve, which is a mixed system;

[0064] (5) Add antioxidant anhydrous sodium thiosulfate (0.0075g) to the mixed system of step (4), and stir to make it fully dissolve;

[0065] (6) Constant volume with water for injection;

[0066] (7) Carry out coarse filtration and fine filtration with o...

Embodiment 3

[0069] Example 3 Veterinary Elliprine-Sulfamethoxazole Injection Preparation Process-3

[0070] The specific process steps are as follows:

[0071] (1) Add a small amount of 1 mL of water for injection to Idiproline (0.2 g), and then add lactic acid (305 μl) to form a salt, which is the salt-forming system 1;

[0072] (2) Salt-forming sulfamethoxazole (1 g) with triethanolamine (1340 μl), which is the salt-forming system 2;

[0073] (3) Add propylene glycol (5.5mL) to the salt-forming system 2 of step (2), and stir to make it fully dissolve, and put it at room temperature for later use;

[0074] (4) Mix the two salt-forming systems of step (1) and step (3), and stir to make it fully dissolve, which is a mixed system;

[0075] (5) Add antioxidant anhydrous sodium thiosulfate (0.01g) into the mixing system of step (4), and stir to make it fully dissolve;

[0076] (6) Constant volume with water for injection;

[0077] (7) Carry out coarse filtration and fine filtration with o...

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Abstract

The invention belongs to the technical field of preparation of veterinary drugs and particularly relates to a veterinary aditoprim (ADP)-sulfamethoxazole (SMZ) compound injection and a preparation method thereof. The injection comprises effective ingredients of ADP and SMZ of which the concentrations by weight / volume percent are respectively 2% and 10%. Propylene glycol serves as a cosolvent of which the concentration by weight / volume percent is 50% in the injection always; water for injection serves as a solvent; anhydrous sodium thiosulfate serves as an anti-oxidant of which the concentration by weight / volume percent is 0.15% always. ADP and SMZ are salified with an additive at first, then various auxiliary materials and the inject solvent are added, the mixture is continually stirred to be uniformly mixed and then subjected to rough filtration and fine filtration, after that, filling and sealing are performed quickly, sterilization under hot press is carried out for 20 min, and finally, leak detection, light inspection and the like are performed to obtain the veterinary ADP-SMZ compound injection. The injection has a simple preparation process, the quality meets the requirements specified in pharmacopeia, a long-acting slow release effect can be taken, and the injection is suitable for treating digestive and respiratory tract infection of livestock, caused by sensitive bacteria.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparation, and in particular relates to a veterinary ideproline-sulfamethoxazole compound injection and a preparation method and application thereof. Background technique [0002] Respiratory system, urinary system and intestinal diseases caused by Escherichia coli, Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, etc. have long plagued my country's animal husbandry industry and become a major problem in the development of the industry. The big obstacle has brought huge economic losses to my country's aquaculture industry. In order to control this type of disease, the country has invested a lot of material and financial resources. Sulfa drugs can inhibit most Gram-positive bacteria and negative bacteria, and play a huge role in controlling bacterial infection diseases. Bacteria, Klebsiella, Salmonella, Proteus, Morganella, Shigella and other Enterobacteriaceae bac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K31/505A61K9/08A61P31/04
Inventor 袁宗辉黄玲利杜曦潘源虎王玉莲陶燕飞戴梦红王旭陈冬梅刘振利谢书宇
Owner HUAZHONG AGRI UNIV
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