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Acidic enrofloxacin injection and preparation method thereof

A technology for the preparation of injections and enrofloxacin, which is applied in the field of preparation of 5% acidic enrofloxacin injections, can solve the problems of poor efficacy of acidic enrofloxacin injections and frequent injections, and achieve the goal of controlling pigs Asthma infection, reduced stress response, reduced morbidity and mortality

Inactive Publication Date: 2011-06-15
上海恒丰强生物技术有限公司
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AI Technical Summary

Problems solved by technology

[0003] The unilateral acidic enrofloxacin injection has the disadvantages of poor clinical effect, need to be administered in combination with other drugs, and many injections

Method used

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Embodiment Construction

[0011] Add 5 grams of enrofloxacin to 80--90ml of water for injection, stir, heat to 50--60C, let cool, add 5 ml of acetic acid and 0.9 ml of benzyl alcohol, stir well, then add 5 grams of lincomycin hydrochloride, Stir until dissolved, and finally add water for injection to 100ml.

[0012] The mixed solution is filled and autoclaved to obtain the product.

[0013] Enrofloxacin is an amphoteric compound, that is, it can form a salt with a base or an acid, and its water solubility increases after forming a salt. Based on the chemical characteristics of enrofloxacin, this prescription is prepared by salting acetic acid and enrofloxacin to prepare its injection. After two years at room temperature, no precipitation and no obvious change in color are seen. PH value: 4.0--4.2 , The content change is within the allowable range and has good stability.

[0014] In summary, the above are only preferred embodiments of the invention, and are not intended to limit the implementation...

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Abstract

The invention relates to an acidic enrofloxacin injection and a preparation method thereof. The acidic enrofloxacin injection comprises the following components: 5g of enrofloxacin, 1.25g of acetic acid, 1ml of benzyl alcohol, 0.5-5 percent of lincomycin hydrochloride and 100ml of injection water. The weights of all components can be changed according to the accurate proportion of the materials and the solution. The preparation method of the injection comprises the following steps of: taking 5g of enrofloxacin to be added into 80-90ml of injection water, stirring, heating to 50-60 DEG C, cooling, adding 1.25g of acetic acid and 1ml of benzyl alcohol, stirring uniformly, then adding 0.5-5g of lincomycin hydrochloride, stirring until dissolving, finally adding the injection water until reaching 100ml, canning, and sterilizing at high pressure.

Description

technical field [0001] The invention relates to a preparation method of 5% acid enrofloxacin injection. technical background [0002] Enrofloxacin is a quinolone antibacterial drug exclusively for veterinary use, and its alkaline injection has been included in the 2005 edition of the Veterinary Pharmacopoeia of the People's Republic of China. I found in the research and development of veterinary medicine, and it has been proved by veterinary clinics that acidic enrofloxacin injection has significant curative effect, non-irritating (basic enrofloxacin injection is very irritating to the injection site), and can be combined with various acidic Drug injection compatibility and other characteristics. [0003] The unilateral acidic enrofloxacin injection has the disadvantages of poor clinical effect, need to be administered in combination with other drugs, and many injections. Contents of the invention [0004] In order to overcome the above problems, the object of the presen...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K31/496A61K9/08A61P31/04A61P11/06
Inventor 龙潭廖洪李敏郭春艳
Owner 上海恒丰强生物技术有限公司
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