Method for preparing enrofloxacin injection

Abstract

The invention discloses a method for preparing an enrofloxacin injection, and belongs to the technical field of veterinary drugs. The injection comprises the following components: enrofloxacin, sodiumhydrogen sulfite, propylene glycol, ethyl alcohol, EDTA, sodium hydroxide and water for injection. The method for preparing the enrofloxacin injection comprises the following steps: the sodium hydrogen sulfite, the EDTA and the sodium hydroxide are dissolved with part of water for injection, respectively, then, the propylene glycol is taken and heated, the sodium hydrogen sulfite aqueous solutionand the EDTA aqueous solution are added, stirring is conducted, the sodium hydroxide solution is added, stirring is carried out, the enrofloxacin is added, stirring is carried out, finally, the ethylalcohol and remaining water for injection are added, stirring is carried out, adsorption is conducted by adding activated carbon, and filtration is carried out to obtain the enrofloxacin injection. By means of the enrofloxacin injection, the technical problems that an existing enrofloxacin injection is poor in stability and prone to precipitation and crystallization in a low-temperature environment are solved, the drug effects are given full play, and the formula cost is low. Besides, the method for preparing the enrofloxacin injection is simple, low in production cost and suitable for production application.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to a method for preparing enrofloxacin injection. Background technique [0002] Enrofloxacin is a broad-spectrum bactericidal drug for fluoroquinolone animals. It is against Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Porter's septicemia Bacteria, Staphylococcus aureus, Mycoplasma, Chlamydia, etc. have good effects, but the effect on Pseudomonas aeruginosa and Streptococcus is weak, and the effect on anaerobic bacteria is weak. It has obvious post-antibacterial effect on sensitive bacteria. The antibacterial mechanism of enrofloxacin is to act on the DNA gyrase of bacterial cells, interfering with the replication, transcription, repair and recombination of bacterial DNA, so that the bacteria cannot grow and reproduce normally and die. [0003] Enroflo...

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Problems solved by technology

[0004] In order to solve the technical problem of poor stability of enrofloxacin injection in the prior art and easy precipitation of crystals in low temperature environment, the object of the present invention is to provide a kind of enrofloxacin injection and preparation method thereof, enrofloxacin of the present invention The injection has good stability in low temperature environment, which is conducive to the full play of the drug effect, low formula and production cost, simple preparation method, and is suitable for production and application

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