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Veterinary synergic enrofloxacin injection and preparation method thereof

A technology of enrofloxacin and injection, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the difficulty of preparing high-concentration enrofloxacin injection, and the product Poor stability and frost resistance, to achieve enhanced antibacterial and antiviral effects, low cost, and short course of treatment

Inactive Publication Date: 2012-02-01
金河牧星(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, one of the objectives of the present invention is to provide a synergistic enrofloxacin injection for veterinary use, which can not only solve the difficulties of high-concentration enrofloxacin injection preparation difficulty, poor product stability and freeze resistance, Moreover, its antibacterial and antiviral effects can be greatly enhanced, and the generation of drug resistance can be effectively reduced; the second purpose is to provide a preparation method of the veterinary synergistic enrofloxacin injection, which is easy to operate and low in cost, suitable for industrial mass production

Method used

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  • Veterinary synergic enrofloxacin injection and preparation method thereof
  • Veterinary synergic enrofloxacin injection and preparation method thereof
  • Veterinary synergic enrofloxacin injection and preparation method thereof

Examples

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Effect test

Embodiment 1、5

[0022] Embodiment 1,5% (g / mL) veterinary synergistic enrofloxacin injection

[0023] Formula: enrofloxacin 5.0g, sodium salicylate 10.0g, isatidis 20.0g, trimethoprim 1.0g, polyethylene glycol 40020.0g, sodium hydroxide 0.1-0.5g, add water for injection to 100mL;

[0024] Preparation method: includes the following steps:

[0025] a. Dissolve sodium salicylate in 40 mL of water for injection, then add enrofloxacin, stir to dissolve completely, and obtain solution A;

[0026] b. Crush the Radix isatidis through a No. 4 sieve, add water to decoct 3 times, add 1 times the amount of water to decoct for 1 hour each time, combine the decoction liquid three times, filter, and add shell with a mass volume fraction of 0.5% to the filtrate Polysaccharide (strong cationic natural biological flocculant), stir well and let stand overnight, then filter through 200-mesh nylon mesh to remove impurities such as starch, protein, tannin and resin, and concentrate the filtrate to 30mL to obtain s...

Embodiment 2、10

[0029] Embodiment 2, 10% (g / mL) veterinary synergistic enrofloxacin injection

[0030] Formula: 10.0g of enrofloxacin, 12.0g of sodium salicylate, 40.0g of Radix isatidis, 2.0g of trimethoprim, 40.0g of polyethylene glycol, 0.5-1.0g of sodium hydroxide, and add water for injection to 100mL;

[0031] Preparation method: the same as the preparation method described in Example 1.

Embodiment 3、10

[0032] Embodiment 3, 10% (g / mL) contrast unilateral enrofloxacin injection

[0033] Recipe: enrofloxacin 10.0g, sodium hydroxide 3.0g, water for injection added to 100mL.

[0034] Preparation method: Dissolve 2.0g of sodium hydroxide in 40mL of water for injection, then add enrofloxacin, stir to dissolve completely, adjust the pH value to 9.5-11.5 with an aqueous solution dissolved in 1.0g of sodium hydroxide, and then add water for injection to 100mL, mix well, filter through a microporous filter membrane with a pore size of 0.45μm, pot it, and sterilize it with circulating steam at a temperature of 120°C and a pressure of 0.15MPa for 25 minutes.

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Abstract

The invention relates to the field of veterinary medicament, in particular to a veterinary synergic enrofloxacin injection. Based on the total amount of 100ml, the injection comprises the following components by weight: 5 to 10g of enrofloxacin, 10 to 12g of sodium salicylate, water extract of 20 to 40g of isatis root, 1 to 2g of trimethoprim, 20 to 40g of polyethylene glycol 400, 0.1 to 1g of sodium hydroxide, and the balance injection water, wherein the mass ratio of the enrofloxacin to the trimethoprim is 5 to 1; and the mass ratio of the trimethoprim to the polyethylene glycol 400 is 1:20. The injection has high stability and freezing resistance, and excellent effect in antibiosis and virus resistance, can effectively reduce generation of drug tolerance, and is particularly suitable for serious mixed infection of bacterium, virus and mycoplasma for animals. The invention also relates to a method for preparing the injection, and has the advantages of convenient operation, low cost and the like.

Description

technical field [0001] The invention relates to the field of veterinary drugs, in particular to a veterinary synergistic enrofloxacin injection and a preparation method of the injection. Background technique [0002] Enrofloxacin is a third-generation fluoroquinolone drug specially used for animals. It has significant curative effect on infections caused by various bacteria and is suitable for digestion caused by sensitive bacteria and mycoplasma in cattle, pigs, poultry, dogs, cats and aquatic animals. System, respiratory system, urinary system and various infectious diseases of skin and soft tissues, mainly used for infections caused by Pasteurella, Haemophilus, Escherichia coli, Salmonella, Streptococcus, Mycoplasma, etc. [0003] With the improvement of people's living standards in recent years, the demand for meat products has increased, and large-scale farms have increased year by year. However, the breeding environment of many farms is not ideal, and the breeding tech...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K31/60A61K31/505A61K47/10
Inventor 陈力肖国君杨大成徐兴然
Owner 金河牧星(重庆)生物科技有限公司
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