Preparation method of slow-released enrofloxacin injection

A slow-release technology of enrofloxacin and enrofloxacin, which is applied to non-active ingredient medical preparations, active ingredient-containing medical preparations, pharmaceutical formulas, etc., can solve the problem of increasing animal emergency and increasing breeding costs, etc. problem, to achieve the effect of prolonging the release time

Inactive Publication Date: 2016-04-20
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the defects of the prior art, and provides a preparation method capable of prolonging the half-life of enrofloxacin injection, so as to solve the need for repeated medications in the treatment process of long-duration animal diseases in the prior art, and increase the emergency response time of animals. and increase the cost of farming

Method used

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  • Preparation method of slow-released enrofloxacin injection
  • Preparation method of slow-released enrofloxacin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of 5% enrofloxacin n-hexanoate injection

[0025] Take 5g of enrofloxacin (reduced pure) and 40g of ethanol, stir and dissolve until clear, add 1g of n-hexanoic acid and slowly stir for complexation for 1 hour, add 5g of PEG and continue stirring until clear, dilute the volume of ethanol to 100ml, filter with a 0.45μm organic membrane, That is 5% enrofloxacin injection.

Embodiment 2

[0027] Preparation of 10% enrofloxacin decanoate injection

[0028] Take 10g of enrofloxacin (reduced pure) and 40g of propylene glycol, stir and dissolve until clear, add 2g of decanoic acid and slowly stir for complexation for 2 hours, add 10g of Tween and continue stirring until clear, propylene glycol to 100ml, and filter through a 0.45μm organic membrane, That is, 10% enrofloxacin decanoate injection was obtained.

Embodiment 3

[0030] Preparation of 15% enrofloxacin laurate injection

[0031] Take 15g of enrofloxacin (pure) and 40g of dimethyl sulfoxide, stir and dissolve until clear, add 3g of lauric acid and slowly stir for complexation for 3h, add 20g of polyvinylpyrrolidone and continue stirring until clear, dimethyl sulfoxide Dilute to 100ml, and filter with a 0.45 μm organic membrane to obtain 15% enrofloxacin laurate injection.

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Abstract

The invention provides a preparation method of a slow-released enrofloxacin injection, and belongs to a slow-released injection for animals. The enrofloxacin injection is prepared from, by weight, 5%-20% of enrofloxacin, 1%-4% of fatty acid, 5%-35% of stabilizer and the balance organic solvent. The preparation method comprises the steps that enrofloxacin and the organic solvent are taken and stirred for dissolution, the fatty acid is added to conduct a complexation reaction with a dissolved product, the stabilizer is added, after sufficient dissolution is achieved, the organic solvent is added for the scale volume, and the slow-released enrofloxacin injection is obtained after membrane filtration is conducted. According to the preparation method of the slow-released enrofloxacin injection, enrofloxacin or a salt hydrate thereof is reacted with the fatty acid to form a new compound, the release time of enrofloxacin can be prolonged, the effective blood drug concentration of a drug in an animal body can be maintained for a long time, and therefore the purposes of decreasing the frequency of drug delivery and reducing drug stress are achieved.

Description

technical field [0001] The invention relates to a preparation method of veterinary injection, in particular to a preparation method of slow-release enrofloxacin injection. Background technique [0002] In recent years, my country's animal husbandry industry has been frequently troubled by large-scale respiratory and digestive tract infectious diseases. Respiratory and digestive tract diseases usually have a high incidence and long course. The group is unbalanced, and at the same time, the invasion of external pathogens cannot be effectively eliminated, resulting in complex pathogens infected after the onset, difficult treatment, long administration cycle, and low cure rate, which has brought great losses to the animal husbandry industry and seriously hindered the health and sustainability of my country's animal husbandry industry. develop. Therefore, the development of long-acting preparations has become an urgent need for clinical treatment. [0003] Enrofloxacin is a speci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/48A61P31/04
CPCA61K9/0019A61K9/08A61K31/496
Inventor 刘荻付旭彬杨保收梁武
Owner TIANJIN RINGPU BIO TECH
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