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Non-aqueous solvent long-acting enrofloxacin injection liquid and preparation process thereof

A technology of enrofloxacin and non-aqueous solvent, applied in the field of medicinal chemistry, can solve the problems of large stress reaction of animals, poor effect, time period of drug effect, etc., and achieve the effects of long action time, good preservation and good stability

Inactive Publication Date: 2018-09-28
四川伴农动保生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: general enrofloxacin injections are likely to cause a large stress response in animals, a period of drug efficacy, and a poor effect. The present invention provides a non-aqueous solvent long-acting enrofloxacin solution Shaxing injection and its preparation process

Method used

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  • Non-aqueous solvent long-acting enrofloxacin injection liquid and preparation process thereof
  • Non-aqueous solvent long-acting enrofloxacin injection liquid and preparation process thereof
  • Non-aqueous solvent long-acting enrofloxacin injection liquid and preparation process thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The invention provides a non-aqueous solvent long-acting enrofloxacin injection, as follows: the formula of the injection is expressed in terms of mass concentration:

[0025]

[0026]

[0027] Among them, the oily solvent is made by mixing ethyl oleate, coix seed oil, and cottonseed oil, and is prepared according to the following ratio in turn: 5:2.5:1.8;

[0028] The co-solvent is prepared by mixing lactic acid, propylene glycol methyl ether, polyvinyl alcohol, and ox bile in a sequential ratio of 10:3.5:0.8:1;

[0029] The local anesthetic is prepared and mixed with benzyl alcohol and benzylamine at a ratio of 3:0.8;

[0030] The blocker is prepared by mixing aluminum stearate, sodium alginate, and glycerin in a ratio of 6:1:1.5 in sequence;

[0031] Antioxidant features Vitamin E.

[0032] The above-mentioned non-aqueous solvent long-acting enrofloxacin injection is obtained through the following preparation process:

[0033] Step A, adding the prescribed a...

Embodiment 2

[0036] The invention provides a non-aqueous solvent long-acting enrofloxacin injection, as follows: the formula of the injection is expressed in terms of mass concentration:

[0037]

[0038] Among them, the oily solvent is made by mixing ethyl oleate, coix seed oil, and cottonseed oil, and is prepared according to the following ratio in turn: 5:2.5:1.8;

[0039] The co-solvent is prepared by mixing lactic acid, propylene glycol methyl ether, polyvinyl alcohol, and ox bile in a sequential ratio of 10:3.5:0.8:1;

[0040] The local anesthetic is prepared and mixed with benzyl alcohol and benzylamine at a ratio of 3:0.8;

[0041] The blocker is prepared by mixing aluminum stearate, sodium alginate, and glycerin in a ratio of 6:1:1.5 in sequence;

[0042] Antioxidant features Vitamin E.

[0043] The above-mentioned non-aqueous solvent long-acting enrofloxacin injection is obtained through the following preparation process:

[0044] Step A, adding the prescribed amount of oil...

Embodiment 3

[0047] The invention provides a non-aqueous solvent long-acting enrofloxacin injection, as follows: the formula of the injection is expressed in terms of mass concentration:

[0048]

[0049] Among them, the oily solvent is made by mixing ethyl oleate, coix seed oil, and cottonseed oil, and is prepared according to the following ratio in turn: 5:2.5:1.8;

[0050] The co-solvent is prepared by mixing lactic acid, propylene glycol methyl ether, polyvinyl alcohol, and ox bile in a sequential ratio of 10:3.5:0.8:1;

[0051] The local anesthetic is prepared and mixed with benzyl alcohol and benzylamine at a ratio of 3:0.8;

[0052] The blocker is prepared by mixing aluminum stearate, sodium alginate, and glycerin in a ratio of 6:1:1.5 in sequence;

[0053] Antioxidant features Vitamin E.

[0054] The above-mentioned non-aqueous solvent long-acting enrofloxacin injection is obtained through the following preparation process:

[0055] Step A, adding the prescribed amount of oil...

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Abstract

The invention discloses non-aqueous solvent long-acting enrofloxacin injection liquid. According to the formula, the injection liquid is prepared from, by mass, 10-20 %(w / v) of enrofloxacin, 80-85 %(w / v) of oily solvent, 10-20 %(w / v) of solubilizer, 10-20 %(w / v) of local anesthetic, 1-5 %(w / v) of suspending agent and 0.8-2 %(w / v) of anti-oxidation aid, wherein a mixture of ethyl oleate, coix seedoil and cottonseed oil is adopted as the oily solvent. The preparation process of the enrofloxacin injection liquid comprises the steps that a prescribed amount of oily solvent is added to a liquid mixing tank, the suspending agent is heated and dissolved, the anti-oxidation aid is added after cooling, and stirring is conducted evenly to obtain a mixed solution for use; the local anesthetic is added in a liquid mixing barrel, enrofloxacin is added, and the solubilizer is added to assist in solubilization; after dissolution, the mixture in the liquid mixing barrel is added to the mixed solution, and mixing is conducted evenly to obtain the injection liquid. By adopting the further optimization of all the components and ratio, the injection liquid has no stress reaction, a drug library can be formed in the injection part, and the long-acting and high-efficiency effect is exerted.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a non-aqueous solvent long-acting enrofloxacin injection and a preparation process thereof. Background technique [0002] Enrofloxacin is the world's first quinolone antibiotic for animals, and enrofloxacin is a broad-spectrum bactericidal drug for fluoroquinolone animals. Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Pottella septicemia Bacteria, Staphylococcus aureus, Mycoplasma, Chlamydia, etc. have good effects, but the effect on Pseudomonas aeruginosa and Streptococcus is weak, and the effect on anaerobic bacteria is weak. It has obvious post-antibacterial effect on sensitive bacteria. [0003] Currently, enrofloxacin dosage forms commonly used in clinical veterinary medicine include tablets, soluble powders, solutions, and injections. However, because...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/496A61K47/44A61K47/14A61P31/04
CPCA61K9/0019A61K9/107A61K31/496A61K47/14A61K47/44A61P31/04
Inventor 郭金鹏
Owner 四川伴农动保生物技术有限公司
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