A kind of enrofloxacin injection and preparation method thereof

A technology for enrofloxacin and injection, applied in the field of enrofloxacin injection and its preparation, can solve the problems of high irritation, low concentration, multiple administration and the like, and achieve the effects of promoting dissolution and lowering pH value
CN105193709BInactive Publication Date: 2017-12-12HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY
Publication Date
2017-12-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an enrofloxacin injection, which comprises: 10-20% enrofloxacin, 10-20% polyethylene glycol 400, 10-20% meglumine, 20% hydrogen sodium oxide. It is prepared by the following steps: measure an appropriate amount of water for injection and heat it to 80°C, add the prescribed amount of meglumine and stir to dissolve, then add polyethylene glycol 400 and stir to dissolve, then add enrofloxacin and stir to dissolve, add an appropriate amount of 20% Sodium hydroxide solution was added dropwise until clarified, stirred evenly, adjusted to pH 9.5-10.5, coarsely filtered, finely filtered, filled with nitrogen, sterilized by autoclaving at 121°C for 20 minutes, inspected by light, and packaged. The invention provides a high-content enrofloxacin injection for veterinary clinics, has little irritation, good stability and long-acting effect.
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Description

technical field

[0001] The invention belongs to the technical field of veterinary medicines, and relates to antibacterial drugs for the prevention and treatment of livestock and aquatic diseases, in particular to an enrofloxacin injection and a preparation method thereof. Background technique

[0002] Enrofloxacin (Enrofloxacin), also known as enfroquiline carboxylic acid, molecular formula: C 19 h 22 FN 3 o 3 , a chemically synthesized bacteriostatic agent belonging to Fluoroquinolones. It is light yellow or light yellow crystalline powder, bitter in taste, insoluble in water, and easily soluble in organic solvents such as sodium hydroxide solution, methanol, and cyanogen. It is a representative of the new generation of quinolone antibacterial drugs, and it is a special new drug for the prevention and treatment of livestock and aquatic diseases. It has a remarkable curative effect on various infections caused by bacteria, especially the lethality to various mycoplasma i...

Claims

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