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A kind of enrofloxacin injection and preparation method thereof

A technology for enrofloxacin and injection, applied in the field of enrofloxacin injection and its preparation, can solve the problems of high irritation, low concentration, multiple administration and the like, and achieve the effects of promoting dissolution and lowering pH value

Inactive Publication Date: 2017-12-12
HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the problems of low concentration and high irritation in the existing enrofloxacin injection, and aims to provide a kind of enrofloxacin injection, which overcomes the problems caused by the low content of the injection and the high pH value of the injection. Large stress response, need for multiple administrations, etc.

Method used

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  • A kind of enrofloxacin injection and preparation method thereof
  • A kind of enrofloxacin injection and preparation method thereof
  • A kind of enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Every 100ml of enrofloxacin injection is prepared through the following steps:

[0014] 1) Take by weighing 20g sodium hydroxide and dissolve in 100ml water for injection to form 20% sodium hydroxide solution, set aside;

[0015] 2) Weigh 20g of meglumine and 20ml of polyethylene glycol 400, respectively dissolve them in 70ml of water for injection at 80°C, and completely dissolve to obtain a mixed solvent;

[0016] 3) Weigh 20g of enrofloxacin and add it into the mixed solvent, stir and dissolve;

[0017] 4) Add 20% sodium hydroxide solution dropwise until clear, stir evenly, make up 100ml of water for injection, and adjust the pH value to 9.5-10.5;

[0018] 5) Coarse filtration, fine filtration, filling with nitrogen, autoclaving at 121°C for 20 minutes, light inspection, and packaging.

Embodiment 2

[0020] Every 100ml of enrofloxacin injection is prepared through the following steps:

[0021] 1) Take by weighing 20g sodium hydroxide and dissolve in 100ml water for injection to form 20% sodium hydroxide solution, set aside;

[0022] 2) Weigh 15g of meglumine and 15ml of polyethylene glycol 400, respectively dissolve them in 70ml of water for injection at 80°C, and completely dissolve to obtain a mixed solvent;

[0023] 3) Weigh 15g of enrofloxacin and add it into the mixed solvent, stir and dissolve;

[0024] 4) Add 20% sodium hydroxide solution dropwise until clarification, adjust the pH value to 9.5-10.5, stir well, and make up 100ml of water for injection;

[0025] 5) Coarse filtration, fine filtration, filling with nitrogen, autoclaving at 121°C for 20 minutes, light inspection, and packaging.

Embodiment 3

[0027] Every 100ml of enrofloxacin injection is prepared through the following steps:

[0028] 1) Take by weighing 20g sodium hydroxide and dissolve in 100ml water for injection to form 20% sodium hydroxide solution, set aside;

[0029] 2) Weigh 10g of meglumine and 10ml of polyethylene glycol 400, respectively dissolve them in 70ml of water for injection at 80°C, and completely dissolve to obtain a mixed solvent;

[0030] 3) Weigh 10g of enrofloxacin and add it into the mixed solvent, stir to dissolve;

[0031] 4) Add 20% sodium hydroxide solution dropwise until clarification, adjust the pH value to 9.5-10.5, stir well, and make up 100ml of water for injection;

[0032] 5) Coarse filtration, fine filtration, filling with nitrogen, autoclaving at 121°C for 20 minutes, light inspection, and packaging.

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Abstract

The invention discloses an enrofloxacin injection, which comprises: 10-20% enrofloxacin, 10-20% polyethylene glycol 400, 10-20% meglumine, 20% hydrogen sodium oxide. It is prepared by the following steps: measure an appropriate amount of water for injection and heat it to 80°C, add the prescribed amount of meglumine and stir to dissolve, then add polyethylene glycol 400 and stir to dissolve, then add enrofloxacin and stir to dissolve, add an appropriate amount of 20% Sodium hydroxide solution was added dropwise until clarified, stirred evenly, adjusted to pH 9.5-10.5, coarsely filtered, finely filtered, filled with nitrogen, sterilized by autoclaving at 121°C for 20 minutes, inspected by light, and packaged. The invention provides a high-content enrofloxacin injection for veterinary clinics, has little irritation, good stability and long-acting effect.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and relates to antibacterial drugs for the prevention and treatment of livestock and aquatic diseases, in particular to an enrofloxacin injection and a preparation method thereof. Background technique [0002] Enrofloxacin (Enrofloxacin), also known as enfroquiline carboxylic acid, molecular formula: C 19 h 22 FN 3 o 3 , a chemically synthesized bacteriostatic agent belonging to Fluoroquinolones. It is light yellow or light yellow crystalline powder, bitter in taste, insoluble in water, and easily soluble in organic solvents such as sodium hydroxide solution, methanol, and cyanogen. It is a representative of the new generation of quinolone antibacterial drugs, and it is a special new drug for the prevention and treatment of livestock and aquatic diseases. It has a remarkable curative effect on various infections caused by bacteria, especially the lethality to various mycoplasma i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/10A61K47/26A61P31/04
Inventor 崔耀明成建国樊克锋李宇伟林莉唐桂芬汤法银郭永刚周延州娄飞
Owner HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY
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