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Enrofloxacin injection and preparation method thereof

A technology of enrofloxacin and injection, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. problem, to achieve the effect of promoting dissolution and reducing pH value

Inactive Publication Date: 2015-12-30
HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the problems of low concentration and high irritation in the existing enrofloxacin injection, and aims to provide an enrofloxacin injection, which overcomes the problems caused by the low content of the injection and the high pH value. Large stress response, need for multiple administrations, etc.

Method used

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  • Enrofloxacin injection and preparation method thereof
  • Enrofloxacin injection and preparation method thereof
  • Enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Each 100ml of enrofloxacin injection is prepared by the following steps:

[0014] 1) Weigh 20g of sodium hydroxide and dissolve in 100ml of water for injection to form a 20% sodium hydroxide solution for use;

[0015] 2) Weigh 20g of meglumine and 20ml of polyethylene glycol 400, and dissolve them in 70ml of water for injection at 80°C, respectively, to completely dissolve to obtain a mixed solvent;

[0016] 3) Weigh 20g of enrofloxacin into the mixed solvent, stir to dissolve;

[0017] 4) Add dropwise 20% sodium hydroxide solution until it is clear, stir evenly, make up 100ml of water for injection, and adjust the pH value to 9.5-10.5;

[0018] 5) Coarse filtration, fine filtration, filling with nitrogen, autoclaving at 121°C for 20 minutes, light inspection, packaging.

Embodiment 2

[0020] Each 100ml of enrofloxacin injection is prepared by the following steps:

[0021] 1) Weigh 20g of sodium hydroxide and dissolve in 100ml of water for injection to form a 20% sodium hydroxide solution for use;

[0022] 2) Weigh 15g of meglumine and 15ml of polyethylene glycol 400, and dissolve them in 70ml of water for injection at 80°C, respectively, to completely dissolve to obtain a mixed solvent;

[0023] 3) Weigh 15g of enrofloxacin into the mixed solvent, stir to dissolve;

[0024] 4) Add dropwise 20% sodium hydroxide solution until it is clear, adjust the pH value to 9.5 to 10.5, stir evenly, and make up 100ml of water for injection;

[0025] 5) Coarse filtration, fine filtration, filling with nitrogen, autoclaving at 121°C for 20 minutes, light inspection, packaging.

Embodiment 3

[0027] Each 100ml of enrofloxacin injection is prepared by the following steps:

[0028] 1) Weigh 20g of sodium hydroxide and dissolve in 100ml of water for injection to form a 20% sodium hydroxide solution for use;

[0029] 2) Weigh 10 g of meglumine and 10 ml of polyethylene glycol 400, and dissolve them in 70 ml of water for injection at 80°C, respectively, to completely dissolve to obtain a mixed solvent;

[0030] 3) Weigh 10g of enrofloxacin into the mixed solvent, stir to dissolve;

[0031] 4) Add dropwise 20% sodium hydroxide solution until it is clear, adjust the pH value to 9.5 to 10.5, stir evenly, and make up 100ml of water for injection;

[0032] 5) Coarse filtration, fine filtration, filling with nitrogen, autoclaving at 121°C for 20 minutes, light inspection, packaging.

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Abstract

The invention discloses enrofloxacin injection which comprises the followings in weight percentage: 10-20% of enrofloxacin, 10-20% of polyethylene glycol 400, 10-20% of meglumine and 20% of sodium hydroxide. The enrofloxacin injection is prepared through the following steps: measuring a proper amount of water for injection, heating the water to 80 DEG C, adding meglumine according to the formulated amount, stirring for dissolution, adding polyethylene glycol 400, stirring for dissolution, adding enrofloxacin, stirring for dissolution, dropwise adding a proper amount of 20% sodium hydroxide solution till clarification, uniformly stirring, adjusting pH to 9.5-10.5, performing rough filtration and refined filtration, filling nitrogen for encapsulation, performing hot-pressing sterilization for 20 minutes at 121 DEG C, performing light inspection, and packaging. According to the invention, high-content enrofloxacin injection for veterinarian clinic is provided, small in irritation and excellent in stability, and has a long-acting function.

Description

Technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to an antibacterial drug for the prevention and treatment of animal husbandry and aquatic diseases, and specifically is an enrofloxacin injection and a preparation method thereof. Background technique [0002] Enrofloxacin (Enrofloxacin), also known as Enfloxacin carboxylic acid, molecular formula: C 19 H 22 FN 3 O 3 It is a chemically synthesized bacteriostatic agent of Fluoroquinolones. It is a yellowish or light yellow crystalline powder, bitter, insoluble in water, and easily soluble in organic solvents such as sodium hydroxide solution, methanol and methyl cyanide. It is a representative of a new generation of quinolone antibacterial drugs and a special new drug for the prevention and treatment of livestock and aquatic diseases. It not only retains the quinolone drug spectrum, high efficiency, low toxicity, good absorption, and convenient administration, but also Various i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/496A61K47/34A61K47/26A61P31/04
Inventor 崔耀明成建国樊克锋李宇伟林莉唐桂芬汤法银郭永刚周延州娄飞
Owner HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY
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