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Enrofloxacin injection and preparation method thereof

A technology for enrofloxacin and injection, applied in the field of enrofloxacin injection and its preparation, can solve problems such as poor stability, and achieve the effects of good stability, easy operation and high bioavailability

Inactive Publication Date: 2017-08-29
山东中牧兽药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of enrofloxacin injection and preparation method thereof, the enrofloxacin injection prepared by the present invention not only solves the technical problem of its poor stability at low temperature, but also facilitates enrofloxacin injection. The curative effect of the liquid is fully exerted, the formula cost is low, and the production process is easy to operate, which is suitable for large-scale production of enterprises

Method used

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  • Enrofloxacin injection and preparation method thereof
  • Enrofloxacin injection and preparation method thereof
  • Enrofloxacin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] An enrofloxacin injection is prepared from the following raw materials in parts by weight: 10 parts of enrofloxacin, 2 parts of meglumine, 0.2 parts of α-mannan peptide, 30 parts of propylene glycol, and 0.01 part of EDTA , 0.5 parts of sodium hydroxide, and 80 parts of water for injection.

[0018] Said, the pH value of enrofloxacin injection is 9.5.

[0019] A preparation method of enrofloxacin injection is prepared by the following steps:

[0020] 1) Take water for injection accounting for 50% of the total amount, add α-mannan peptide, stir to dissolve it, and obtain solution A;

[0021] 2) Add enrofloxacin, meglumine, propylene glycol and EDTA to the remaining 50% water for injection to obtain solution B;

[0022] 3) Add solution A to solution B, stir evenly, adjust pH with sodium hydroxide, filter with 0.45 μm microporous membrane, fill in an ampoule, then sterilize at 110°C for 40 minutes under circulating steam, cool to room temperature, packed to obtain enrof...

Embodiment 2

[0025] An enrofloxacin injection is prepared from the following raw materials in parts by weight: 6 parts of enrofloxacin, 6 parts of meglumine, 0.4 parts of α-mannan peptide, 20 parts of propylene glycol, and 0.03 parts of EDTA , 0.7 parts of sodium hydroxide, and 75 parts of water for injection.

[0026] Described, the pH value of enrofloxacin injection is 10.

[0027] A preparation method of enrofloxacin injection is prepared by the following steps:

[0028] 1) Take water for injection accounting for 50% of the total amount, add α-mannan peptide, stir to dissolve it, and obtain solution A;

[0029] 2) Add enrofloxacin, meglumine, propylene glycol and EDTA to the remaining 50% water for injection to obtain solution B;

[0030] 3) Add solution A to solution B, stir evenly, adjust pH with sodium hydroxide, filter with 0.45 μm microporous membrane, fill in an ampoule, then sterilize at 110°C for 40 minutes under circulating steam, cool to room temperature, packed to obtain e...

Embodiment 3

[0033] An enrofloxacin injection is prepared from the following raw materials in parts by weight: 2.5 parts of enrofloxacin, 8 parts of meglumine, 0.5 parts of α-mannan peptide, 10 parts of propylene glycol, and 0.05 parts of EDTA , 0.9 parts of sodium hydroxide, and 70 parts of water for injection.

[0034] Said, the pH value of enrofloxacin injection is 10.5.

[0035] A preparation method of enrofloxacin injection is prepared by the following steps:

[0036] 1) Take water for injection accounting for 50% of the total amount, add α-mannan peptide, stir to dissolve it, and obtain solution A;

[0037] 2) Add enrofloxacin, meglumine, propylene glycol and EDTA to the remaining 50% water for injection to obtain solution B;

[0038] 3) Add solution A to solution B, stir evenly, adjust pH with sodium hydroxide, filter with 0.45 μm microporous membrane, fill in an ampoule, then sterilize at 110°C for 40 minutes under circulating steam, cool to room temperature, packed to obtain en...

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Abstract

The invention discloses enrofloxacin injection. The enrofloxacin injection is prepared from, by weight, 2.5-10 parts of enrofloxacin injection, 2-8 parts of meglumine, 0.2-0.5 part of alpha- mannatide, 10-30 parts of propylene glycol, 0.01-0.05 part of EDTA, 0.5-0.9 part of sodium hydroxide, and 70-80 parts of water for injection. The enrofloxacin injection is quick to absorb after injection, long in elimination half-life, high in bioavailability, and good in stability; during the injection, the aching feeling can be reduced; the enrofloxacin injection solves the technical difficulty of poor stability under the low temperature, and is good for the fully display of the treatment effect of the enrofloxacin injection; moreover, the formula cost is low, and the manufacturing process is easy to operate; therefore, the enrofloxacin injection is suitable for large-scale production of enterprises.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to an enrofloxacin injection and a preparation method thereof. Background technique [0002] Enrofloxacin, also known as ethyl cyclopropyl (norfloxacin) is the first fluoroquinolone drug for livestock and poultry. The English name is Enrofloxacin, which is the ethyl compound of ciprofloxacin and is the third generation Quinolones have a broad-spectrum bactericidal effect and are effective against bacteria in both stationary and growing phases. [0003] Enrofloxacin was first successfully developed by Bayer AG in Germany in the 1980s, and has now entered most countries and markets in the world. It was successfully developed in my country in 1993 and has been widely used in veterinary clinics. Enrofloxacin has the characteristics of broad antibacterial spectrum, strong bactericidal activity, wide distribution in the body, and no cross-resistance with other antibacterial dru...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/496A61K47/36A61K47/26A61P31/04
CPCA61K9/0019A61K9/08A61K31/496A61K47/26A61K47/36
Inventor 王统高
Owner 山东中牧兽药有限公司
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