Novel antineoplastic compound Ananaside C in sea cucumber

A technology of anti-tumor drugs and compounds, applied in the field of medicine

Inactive Publication Date: 2009-03-04
宁波保税区欣诺生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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The chemical structure and antitumor activity of the s

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  • Novel antineoplastic compound Ananaside C in sea cucumber
  • Novel antineoplastic compound Ananaside C in sea cucumber
  • Novel antineoplastic compound Ananaside C in sea cucumber

Examples

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Embodiment Construction

[0027] The following examples further describe the separation and preparation of Ananaside C.

[0028] Wash 1000 grams of Plum Blossom Ginseng, chop it, soak it in turn with 5 times the amount (weight) of 95%, 85%, and 85% ethanol respectively, soak for 7 days each time, combine the ethanol extract, reclaim the ethanol under reduced pressure, and obtain the flow leaching paste. Dissolve the liquid extract in 3 times the amount of water, filter, and pass the filtrate through a DA201-B macroporous resin column, elute with water and 50% ethanol in sequence, collect the 50% ethanol eluate, recover ethanol under reduced pressure until dryness, and obtain total saponins 5.6 grams. The total saponins were subjected to silica gel column chromatography, eluted with a solvent of dichloromethane:methanol:water at a ratio of 7.3:2.7:1, and fractions containing Ananaside C were collected. After Zorbax SBC18 high performance liquid chromatography, eluting with methanol:water 65:35 as the ...

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Abstract

The invention relates to the pharmaceutical technical field, particularly to an anti-cancer compound Ananaside C having a molecular formula of C41H63O17SNa and separated from thelenota ananas. The chemical structure and the spatial configuration of the compound are determined by various modern spectral analytic methods, particularly the comprehensive resolution of the advanced two-dimensional nuclear magnetic resonance spectroscopy and the high-resolution mass spectroscopy. A vitro anti-tumor experiment shows that the compound has the remarkable effect of inhibiting eight kinds of tumor cell strains such as A-549 lung caner, IA-9 ovary cancer and the like. The invention provides a precursor compound for developing a new anti-tumor pharmaceutical, and has the important value on the development and the utilization of the national marine medicinal organism resource.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a new antitumor compound Ananaside C isolated from marine animal ginseng. Background technique [0002] Plum ginseng (Thelenota ananas J.), also known as "pineapple ginseng", belongs to the sea cucumber family Aposticaceae of the marine echinodermata. Its body is very large, generally 700mm in length, 100mm in width, and 80mm in height. It is widely distributed in my country's Xisha Islands and the southern tip of Taiwan. Its body is rich in protein, polysaccharides, vitamins, and saponins, which have the effects of nourishing the liver and kidney, benefiting essence, and nourishing blood. The chemical structure and antitumor activity of the saponins contained in it have not been reported so far. Contents of the invention [0003] The present invention extracts and separates a new saponin compound from plum blossom ginseng grown in the sea area of ​​Fujian, China, named Ananaside C, a...

Claims

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Application Information

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IPC IPC(8): C07J71/00A61K31/7048A61P35/00
Inventor 巫军
Owner 宁波保税区欣诺生物技术有限公司
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