Uses of salvianolic acid B in preparing medicament formulation for preventing and controlling osteoporosis

A technology of salvianolic acid and osteoporosis, which is applied in the field of application of salvianolic acid B in the preparation of pharmaceutical preparations for the prevention and treatment of osteoporosis, and can solve the problems of unreported effects of osteoporosis, reduction of bone quality, adverse reactions, etc.

Inactive Publication Date: 2009-04-08
GUANGDONG MEDICAL UNIV
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  • Abstract
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Problems solved by technology

The first category is the main drug for the prevention and treatment of postmenopausal osteoporosis, but there are serious adverse reactions. The most serious adverse reaction is to stimulate endometrial hyperplasia and increase the incidence of endometrial cancer. Increase the incidence of breast cancer and cause uterine bleeding, etc.
The second type is more suitable for senile osteoporosis, but this type of drug is still in the initial stage of research and development, and has a good prospect. Its representative drug fluoride has been proved to increase bone mass, but it will reduce bone mass and induce secondary osteoporosis. sex fracture
The third class of drugs has clear curative effect and is safe, but there are also some adverse reactions
[0021] However, the effect of salvianolic acid B on osteoporosis has not been reported so far. This study found that salvianolic acid B has obvious anti-osteoporosis effect

Method used

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  • Uses of salvianolic acid B in preparing medicament formulation for preventing and controlling osteoporosis
  • Uses of salvianolic acid B in preparing medicament formulation for preventing and controlling osteoporosis
  • Uses of salvianolic acid B in preparing medicament formulation for preventing and controlling osteoporosis

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Embodiment 1

[0024] 1. Group administration of experimental animals and preparation of drugs

[0025] 1.1 Experimental animals and feeding conditions

[0026]Thirty-two adult female non-pregnant SD rats of SPF grade, weighing 271.67±25.63g, were provided by Guangdong Experimental Animal Center. Feeding conditions: The temperature in the feeding room was kept at 24°C to 28°C, the humidity was at 50% to 60%, and they were reared in separate cages in a special room, with two in each cage. feed), and weighed once a week.

[0027] 1.2 Experimental design and grouping

[0028] During the ovariectomized experiment, the rats in each group except the sham operation group were treated with 3% pentobarbital sodium sterile solution 0.13ml·100g -1 BW was anesthetized by intraperitoneal injection. Under aseptic conditions, bilateral ovaries were surgically removed and then sutured. Rats in the sham operation group only incised the muscle layer and entered the abdominal cavity to find the ovaries with...

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Abstract

The invention relates to a method for preparing a pharmaceutical preparation from salvianolic acid B for preventing and treating osteoporosis. Studies show that the pharmaceutical preparation prepared from the salvianolic acid B has extremely obvious functions for preventing and treating high-conversion type osteoporosis caused by the removal of ovarian rats, can be applied to preventing and treating senile osteoporosis clinically, and particularly has better functions for preventing and treating post-menopausal osteoporosis and the osteoporosis caused by medicaments of glucocorticoid.

Description

technical field [0001] The invention relates to the application of salvianolic acid B preparation in preventing and treating senile osteoporosis. Background technique [0002] Primary osteoporosis is a common disease of the elderly. From the perspective of the whole world, the proportion of the elderly over 60 years old in the whole population is constantly increasing. my country has entered an aging society, so it is necessary to pay attention to the health of the elderly and improve Quality of life appears to be very important. Due to osteoporosis, the incidence of vertebral fractures and hip fractures in the elderly is increasing, the complications are serious, they often lie in bed for a long time, lose their ability to live, and the mortality rate is as high as 15-30%. Therefore, the prevention and treatment of senile osteoporosis is not only a modern medical field The urgent problem to be solved is also a socialization problem. [0003] Primary osteoporosis is essenti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P19/10
Inventor 吴铁崔燎张益嘉张新乐李彬
Owner GUANGDONG MEDICAL UNIV
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