14 results about "Senile osteopenia" patented technology

The invention provides a multi-modal data and interaction quantification-based senile osteoporosis dynamic risk assessment method. The method comprises the steps of screening effective variables in candidate risk factors; collecting structured data and unstructured data, and cleaning and standardizing the data to obtain multi-mode data of a patient; calculating a statistical weight and a clinical weight to obtain a multi-dimensional weight, calculating a dynamic total risk integral of an effective variable, and quantifying a variable interaction effect; and carrying out risk level layering and clinical intervention suggestion to obtain a dynamic risk assessment result, and then carrying out internal cross validation and external data set validation. According to the method, data full coverage, weight self-adaption and risk dynamic interaction analysis can be achieved, scientificity, sensitivity and clinical friendliness of osteoporosis screening are greatly improved, the method is low in cost and high in prediction precision, risk grading is associated with specific prevention and treatment measures, and a prevention and treatment integrated information closed loop is achieved.

The invention relates to the technical field of biological medicines, in particular to application of hsacirc0008126 in prevention and treatment of senile osteoporosis. The invention provides the circular RNA hsacirc0008126 which can be used for regulating and controlling the mesenchymal stem cell osteogenesis and adipogenic differentiation, the mechanism of the circular RNA hsacirc0008126 on the mesenchymal stem cell osteogenesis and adipogenic differentiation is different from that of the prior art, the medicine taking the circular RNA hsacirc0008126 as the target spot can be used for treating and / or preventing osteoporosis, and the circular RNA hsacirc0008126 has important application value.

The invention relates to the technical field of rehabilitation medical treatment and human-computer interaction, and discloses a rehabilitation method for senile osteoporosis with cognitive impairment based on augmented reality. The method comprises the steps that movement and physiological data of a patient are collected, a synchronous calibration signal is obtained through a fusion algorithm and Kalman filtering, and a virtual and real environment deviation value is determined in combination with the rehabilitation progress and pain feedback; optimizing response parameters and real-time force feedback parameters of the virtual scene through an adaptive adjustment mechanism, and extracting dynamic demand characteristics of the patient; fusing the dynamic demand features, audiovisual, tactile and interaction delay data through a convolutional neural network to obtain a virtual-real interaction feedback sequence; and generating virtual scene update data and an auxiliary device supporting force simulation value based on the sequence, and synthesizing a rehabilitation training output signal. According to individual requirements of patients, accurate virtual environments and interactive feedback are provided, dynamic accurate matching of virtual and real environments and real-time adaptation of multi-modal feedback in rehabilitation training are achieved, and the immersion feeling and rehabilitation effect of training are improved.

The invention relates to the related technical field of medical drugs, in particular to an anti-osteoporosis pill based on hydroxyapatite combined Erzhi pill and a preparation method thereof, the pill comprises a nano-hydroxyapatite carrier (Ca / P = 1.67: 1, and the particle size is 20-100nm), Erzhi pill active components (the compatibility of ligustrum lucidum ait total glycoside and eclipta ethyl acetate part is 1: 1) and pharmaceutical auxiliary materials, through ionic bond / hydrogen bond loading, the drug loading ratio is (5-20): 1. The preparation method comprises the following steps: synthesizing nano-hydroxyapatite by a hydrothermal method, extracting active components of Erzhi pills by using ethanol, adsorbing and carrying medicines by using a buffer solution with the pH value of 7.4, and tabletting and forming. According to the anti-osteoporosis pill based on the hydroxyapatite combined Erzhi pill and the preparation method of the anti-osteoporosis pill, the synergistic anti-osteoporosis effect is achieved by up-regulating bone morphogenetic genes (osterix, OCN), inhibiting osteoclast genes (c-Src, cathepsin K) and regulating an LCN2 / Sema3A pathway, the targeting property is high, the bioavailability is high, and the anti-osteoporosis pill is suitable for treating postmenopausal and senile osteoporosis.

The invention relates to application of a TRMT10C agonist TM3 in preparation of a medicine for treating senile osteoporosis, and belongs to the technical field of biological medicines. According to the invention, the TRMT10C agonist TM3 is used for treating senile osteoporosis for the first time. A mouse experiment verifies that the TRMT10C agonist TM3 can inhibit bone loss of a mouse with osteoporosis, increase the bone density, the number of bone trabecula and the volume fraction of the bone trabecula, reduce the separation degree of the bone trabecula and promote bone formation. It is fully proved that the TRMT10C agonist TM3 can be used for treating the senile osteoporosis caused by the fact that the osteogenesis rate is remarkably reduced due to age increase, and therefore the TRMT10C agonist TM3 can be used for preparing the medicine for treating the senile osteoporosis and has important significance in clinical treatment of the senile osteoporosis in the future.

The invention relates to a vertebral stability assessment method and system for senile osteoporosis vertebral compression fracture. The method comprises the following steps: collecting dynamic stress data and cone motion data of a target cone in real time, and calculating a stress concentration coefficient, an energy dissipation rate and a motion coupling degree; performing weighted calculation processing on the stress concentration coefficient, the motion coupling degree and the energy dissipation rate to obtain an initial stability index, and performing neural network verification processing on the initial stability index and the bone mineral density value to obtain a dynamic stability index; and according to a preset grading standard, carrying out grading and strategy matching processing on the dynamic stability index to obtain a vertebral stability grade and a corresponding treatment strategy. According to the method, dynamic stress and motion data are collected in real time, multi-parameter calculation is fused, a dynamic stability index is obtained through neural network verification, precise evaluation and personalized treatment strategy matching of the vertebral stability are achieved, and evaluation comprehensiveness and treatment pertinence are improved.

The utility model relates to the technical field of walking auxiliary equipment, and discloses an old people osteoporosis anti-falling device which comprises a machine frame, first universal wheels are arranged on the rear side of the machine frame, a pedal beam sleeve is fixedly connected to the front side of the machine frame, and belt wheel bottom frames are arranged on the two sides of the interior of the pedal beam sleeve. And plum blossom handle screws are in threaded connection with the interiors of the belt wheel bottom frames correspondingly, plum blossom handle screws are in threaded connection with the interiors of the pedal beam sleeves correspondingly, second universal wheels are arranged at the bottoms of the belt wheel bottom frames correspondingly, and rack plates are arranged in the rack correspondingly. According to the utility model, through the arrangement of the armrest clamping groove and the pedal cross beam sleeve, the space occupied by the equipment is reduced, the safety is improved, the use flexibility of the equipment is improved, through the arrangement of the gear and the rack plate, the equipment is suitable for old people with different heights, and the use range of the equipment is expanded; and therefore, anti-falling protection can be conveniently carried out on the old people with different heights.

The application discloses application of black corn polysaccharide in preparation of a medicine for preventing or treating senile osteoporosis. The evaluation of the prevention or treatment effect of the black corn polysaccharide on senile osteoporosis includes improvement effects on serum bone metabolism markers, bone microstructure and bone biomechanics. The black corn polysaccharide of the application refers to a polysaccharide powder after water extraction, alcohol precipitation, Sevag method deproteinization, H2O2 method depigmentation and dialysis bag dialysis from dried black corn kernels. The black corn polysaccharide has improvement effects on imbalance of serum bone metabolism markers of senile osteoporosis, deterioration of bone microstructure and decrease of bone strength. The results show that the black corn polysaccharide has great improvement effects on bone loss in preventing senile osteoporosis. Therefore, the black corn polysaccharide has important significance in developing senile osteoporosis in clinic.

The invention provides a movable fixing device for senile osteoporosis spinal fracture, and relates to the technical field of fracture fixtion.The movable fixing device for senile osteoporosis spinal fracture comprises a seat body, a patient sits on a seat plate, a lifting rod is clamped under the armpit, and a lifting driving part can drive the lifting rod to move upwards; when the lifting rods are lifted, the two limiting columns can rotate to the position between the two lifting rods, the two limiting columns are connected and fixed through the connecting part, the translation driving part drives the limiting columns to move towards the patient, and therefore the patient can be lifted upwards, and the spine and the vertebra of the patient can be prevented from being pressed. The limiting columns can clamp the upper body of the patient under the cooperation of the limiting columns and the backup plate, so that the spine of the patient can be fixed to the backup plate, the effect of fixing the spine is achieved, and in conclusion, in the process of guaranteeing healing and rehabilitation of the patient, the device can move outdoors to adjust the mental health of the patient.

The present application provides a kind of lignan composition for resisting osteoporosis and its application, the composition is composed of pinoresinol diglucoside, dehydrodiconiferyl alcohol-4, γ'-bis-O-β-D-glucopyranoside, pinoresinol monoglucoside component;The mass ratio of pinoresinol diglucoside: dehydrodiconiferyl alcohol-4, γ'-bis-O-β-D-glucopyranoside: pinoresinol monoglucoside is 1:0.1-0.3:0.2-0.4.The lignan composition provided by the present application is stable in quality, high in safety, suitable for long-term taking, and has good effect on treating osteoporosis.The composition can be used for senile osteoporosis, and has more significant effect on inhibiting bone density reduction in ovary-removed female rat osteoporosis model.

The application discloses a traditional Chinese medicine composition and preparation for senile osteoporosis and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The composition comprises the following components: rhizoma drynariae, eucommia ulmoides, rhizoma curculiginis, angelica sinensis, rhizoma smilacis, radix angelicae pubescentis, acanthopanax, safflower, herba epimedii, taxillus, cistanche deserticola, radix astragali, radix rehmanniae preparata, rhizoma dioscoreae, cornus officinalis, cynomorium, rhizoma anemarrhenae, cornu cervi, herba monochori. The preparation is prepared from the traditional Chinese medicine raw material of the composition, and the preparation method comprises the following steps: mixing the above raw materials, soaking in water, and then decocting; and after decocting, taking medicinal liquid, and the obtained medicinal liquid can be used as a decoction or further processed into other Chinese patent medicine preparations according to a conventional process. The traditional Chinese medicine composition and the preparation thereof can treat senile osteoporosis through multiple targets and multiple pathways, have the characteristics of being simple, cheap and safe, can better reduce the burden of patients, and meet the diagnosis and treatment needs of patients.

The application discloses an inflammation-targeted Prussian blue nanolipase and a preparation method and application thereof, and the nanolipase can be used for preparing a drug for treating senile osteoporosis and age-related diseases, and the nanolipase comprises a macrophage membrane and citric acid modified Prussian blue nanoparticles wrapped in the macrophage membrane, the method comprises the following steps: preparing the citric acid modified Prussian blue nanoparticles, extracting the macrophage membrane, mixing a solution of the Prussian blue nanoparticles and a suspension of the macrophage membrane and carrying out ultrasonic treatment, and carrying out solid-liquid separation after stirring. The application solves the problems of short half-life and poor targeting of the existing nanolipase for treating osteoporosis, reduces off-target toxicity and enhances the stability of the curative effect, the nanolipase can more efficiently remove active oxygen, inhibit osteoclast differentiation, relieve bone loss and does not affect osteogenesis, and the nanolipase realizes long-acting, safe and efficient osteoporosis treatment as a whole, and has the application potential of being expanded to other age-related inflammatory diseases.

The invention provides a traditional Chinese medicine formula for treating senile osteoporosis and a preparation method, and belongs to the field of traditional Chinese medicines. The method comprises the following steps: pretreating medicinal materials, performing ultrasonic-assisted decoction extraction, performing a concentration process, performing a drying process, preparing pills and the like. The rhizoma polygonati muscle and bone prescription disclosed by the invention is an agreement prescription obtained by adding a basic prescription of a rhizoma polygonati pill for treating senile osteoporosis, is clinically used for many years, shows a good curative effect of resisting senile osteoporosis, and has no adverse drug reaction. The pharmaceutical composition has a more comprehensive pharmacological action, a more scientific preparation process and a dosage form design which is more in line with modern requirements. The traditional advantages of the Huanshui rhizoma polygonati pill are continued, and the medicine effect and the taking experience are further optimized through the innovation of medicinal material compatibility and the introduction of the modern pharmaceutical technology. Due to the characteristics, the rhizoma polygonati muscle and bone prescription can better meet the requirements of different patients when being used for clinically treating the senile osteoporosis, and a more remarkable treatment effect is achieved.

This invention discloses the application of atormoxetine in the preparation of drugs that increase H-subtype endothelial cells in bone vessels. Specifically, it discloses the application of a combination of atormoxetine and deferoxamine mesylate in the preparation of drugs that increase H-subtype endothelial cells in bone vessels, drugs that increase bone mineral density, or drugs for treating osteoporosis. This invention discovers that the combined use of atormoxetine and deferoxamine mesylate can further promote the generation of H-subtype bone vascular endothelial cells. The generation of H-subtype bone vascular endothelial cells leads to an increase in the bone mineral density coupled with them, thus promoting bone formation. Using this combined medication, the treatment of senile osteoporosis can be achieved.