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Preparation and application of esmolol sustained release tablets

A technology of sustained-release tablets and sustained-release materials, applied in the new field of drugs, can solve problems such as adverse reactions, and achieve the effects of small toxic and side effects, long action time, and stable blood drug concentration.

Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, due to the relatively common adverse reactions in the administration of injections

Method used

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  • Preparation and application of esmolol sustained release tablets

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0052] Specific embodiments are as follows, but do not limit the present invention in any way.

Embodiment 1

[0055] Esmolol 300g

[0056] Ethyl cellulose 50g

[0057] Diethyl phthalate 10g

[0058] Lactose 150g

[0059] Talc powder 10g

[0060] 95% ethanol appropriate amount

[0061] Preparation process: dissolve ethyl cellulose and diethyl phthalate with 95% ethanol, add esmolol while stirring to dissolve completely, wave off ethanol, add lactose and talcum powder in the prescribed amount, mix well, press Slices, ready to serve.

Embodiment 2

[0063] Esmolol 300g

[0064] Ethylcellulose 15g

[0065] Stearic acid 25g

[0066] Diethylphthalate 2g

[0067] Talc powder 10g

[0068] Microcrystalline Cellulose 200g

[0069] 95% ethanol appropriate amount

[0070] Preparation process: dissolve ethyl cellulose, diethyl phthalate and stearic acid with 95% ethanol, add esmolol while stirring to dissolve completely, evaporate ethanol, add microcrystalline cellulose and Talcum powder, mixed evenly, compressed into tablets, ready to be prepared.

[0071] Prescription C:

[0072] Esmolol 300g

[0073] Ethyl cellulose 20g

[0074] Eudragit RS100 25g

[0075] Macrogol 6000 10g

[0076] Talc powder 15g

[0077] Microcrystalline Cellulose 250g

[0078] 95% ethanol appropriate amount

[0079] Preparation process: Dissolve ethyl cellulose, Eudragit RS100 and polyethylene glycol 6000 with 95% ethanol, add esmolol while stirring to dissolve completely, evaporate ethanol, add microcrystalline cellulose and talcum powder in th...

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Abstract

The invention belongs to the novel technical field of medicament and specifically relates to esmolol sustained release tablets used to control ventricular rate when treating atrial fibrillation and atrial flutter, hypertension during perioperative period and sinus tachycardia. The esmolol sustained release tablets are made from esmolol, filler, sustained release agent, plasticizer and antisticking agent between which the weight ratio is 30:(10-500):(10-300):(0-100):(0-100). Ethanol is used to prepare slurry, and weight of the antisticking agent is 1% that of the ethanol. The inventive Chinese traditional medicine is slowly released so as to maintain relatively stable blood concentration and longer action time, and has advantages of reducing side effect, more convenient administration etc.

Description

technical field [0001] The invention belongs to the field of new medicine technology, and relates to a new dosage form of esmolol, which is used for controlling ventricular rate when treating atrial fibrillation and atrial flutter; perioperative hypertension; and a pharmaceutical preparation for sinus tachycardia and its preparation The method, specifically the preparation and application of an esmolol sustained-release tablet. Background technique [0002] Esmolol hydrochloride (esmolol) is the first ultra-short-acting, selective second-generation β-receptor blocker and β1 adrenergic receptor blocker currently used clinically; this product is used as a Ultra-short-acting selective β1-receptor blockers, which have rapid onset and short duration of action, have attracted attention. Abroad has been widely used in the treatment of supraventricular tachyarrhythmia, acute arterial syndrome and perioperative hypertension, tachycardia, myocardial ischemia and so on. [0003] The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61K9/22A61K47/34A61K47/38A61P9/06A61P9/12
Inventor 王翰斌
Owner BEIJING HOPE HUGE PHARM SCI
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